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#oxidativestress

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Public
Victoria Stuart 🇨🇦 🏳️‍⚧️

Mitochondrial fatty acid oxidation drives senescence
science.org/doi/10.1126/sciadv

* cellular senescence: stress-induced irreversible cell cycle arrest in tumor suppression/aging
* pharmacological activation of fatty acid oxidation induced senescence in vitro/in vivo
* mitochondrial energy metabolism: critical role in senescence induction
* potential intervention to control senescence

#ageing#aging#senescence
Public
Rhyothemis

research article from 2011:

Loss of functional albumin triggers acceleration of transthyretin amyloid fibril formation in familial amyloidotic polyneuropathy
nature.com/articles/labinvest2

"Human serum albumin, the most abundant protein in plasma, serves as a transporter of various ligands and an antioxidant in blood circulation. Human serum albumin is a mixture of a reduced form (human mercaptalbumin: HMA) and an oxidized form (human nonmercaptalbumin: HNA). Albumin is the major antioxidant in plasma, and a large proportion of all the serum antioxidant properties can be attributed to albumin. Previous work has shown the total reactive antioxidant potential in plasma, considered as an index of the level of antioxidants, decreased in patients with FAP. In addition, more recent work demonstrated that albumin suppressed amyloid formation of amyloid-β(Aβ), a component of amyloid fibrils in Alzheimer's disease, by reducing oxidative stress. These data suggest that albumin functing as an antioxidant may perform a crucial role in amyloid formation in FAP."

NatureLoss of functional albumin triggers acceleration of transthyretin amyloid fibril formation in familial amyloidotic polyneuropathy - Laboratory InvestigationTransthyretin (TTR)-related familial amyloidotic polyneuropathy (FAP) is characterized by systemic accumulation of amyloid fibrils caused by a point mutation in the TTR gene. Despite the urgent need for alternative therapeutic strategies, the pathogenesis of FAP still remains elusive. In our study reported here, we focused on albumin, the most abundant protein in plasma, and described the role of albumin in the TTR amyloid-formation process. Patients with FAP evidenced significantly decreased serum albumin levels as the disease progressed. Biacore analysis showed that albumin had a binding affinity for TTR and exhibited higher affinity for TTR amyloid than native TTR. Albumin functioning as an antioxidant effectively suppressed TTR amyloid formation. In patients with FAP, albumin was significantly oxidized as the disease progressed. Moreover, loss of functional albumin accelerated TTR deposition in analbuminemic rats possessing a human variant TTR gene. Taken together, these results indicate that albumin may have an inhibitory role in the TTR amyloid-formation process.
#amyloidosis#albumin#OxidativeStress
Public
Lukas VFN 🇪🇺

Study illuminates the protective role of #fluorescence in neon-colored sea anemones
phys.org/news/2024-03-illumina

#FluorescentProteins generate a genetic color polymorphism and counteract #OxidativeStress in intertidal #SeaAnemones pnas.org/doi/10.1073/pnas.2317

"The team turned to the community platform #iNaturalist, which empowers #CitizenScientists to document #biodiversity in their quest to find locations of the sometimes rare neon-green sea anemones."

Underwater photo of a sea anemone - a small flower-like invertebrate animal with many tentacles
Public
Gonzalo

Just Published!

Molecular Hydrogen in Health and Disease

Read here: link.springer.com/book/10.1007

Molecular hydrogen (H2) has gained attention as a promising medical gas with antioxidant and anti-inflammatory properties. Hydrogen shows potential in addressing various health issues, from cardiac conditions to inflammatory diseases, aging-related disorders, and more.

Enjoy!

#OxidativeStress#Inflammation#Aging
Public
Lukas VFN 🇪🇺

#Solar-powered Sea Slugs oceanbites.org/solar-powered-s

Assessing behavioral and physiological #photoprotective mechanisms in tropical solar-powered #SeaSlugs exposed to natural light intensities link.springer.com/article/10.1

"Prior studies have underestimated the amount of natural light exposure... new study corrects this and found light exposure far exceeds what is needed for optimal #photosynthesis in these #animals... This can lead to #OxidativeStress... Each demonstrated a behavior to reduce injury"

photos of 3 different species of sea slugs - aquatic invertebrates related to snails but with no shell
Public
John Hobbs

#NutrientScience
1/5

In our continuous journey to unearth the treasures of wellness, today we're illuminating the profound health benefits of Alpha Lipoic Acid (ALA), a potent antioxidant. ALA has shown impressive results in several health domains, from reducing #OxidativeStress to improving nerve function, and a slew of studies substantiate these claims. 🌿

Image that illustrates the molecular structure of Alpha Lipoic Acid.
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