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**Furqan Shah** @furqanshah@mstdn.science · Dec 16, 2024

Dec 16, 2024

Furqan Shah @furqanshah@mstdn.science

Biomaterial design principles to accelerate #bone tissue #engineering

Dewey & Harley, 2022

https://doi.org/10.1007/978-3-030-92014-2_3

Healing of bony defects is a unique challenge due to the complex mechanical properties, irregular shapes, and critical size of missing bone. Bone defects that require surgery are typically caused by significant missing portions of bone and the methods of repair involve surgical implantation of a biomaterial. The gold standard for this repair is the use of autografts, but these can lead to bone morbidity. Alternatives include allografts and xenografts; however, multiple challenges associated with their use motivate tissue engineering efforts. To date, a wide spectrum of efforts have explored the design of osteogenic or osseoinductive biomaterials such as polymers, metals, and ceramics. Increasingly, efforts have also explored alternative fabrication approaches to create patient-specific implants. These efforts include adaptation of generative design principles and 3D printing to create unique geometries, methods to incorporate exogenous cell sources, and the use of conventional and exotic growth factor patterning and release approaches to further improve biological response. Here, we discuss the mechanisms of bone repair, the current available technologies, biomaterial design criteria, 3D printing as a fabrication method, and the influence of cells and growth factors on bone repair.

#biomaterials #biomineralization #collagen

**Furqan Shah** @furqanshah@mstdn.science · Sep 1, 2024

Sep 1, 2024

Furqan Shah @furqanshah@mstdn.science

Multifaceted bone response to immunomodulatory magnesium implants: Osteopromotion at the interface and adipogenesis in the bone marrow

https://doi.org/10.1016/j.biomaterials.2024.122779

$Orthopedic implants made of biodegradable magnesium (Mg) provide an alternative to nondegradable implants for fracture repair. Widely reported to be pro-osteogenic, Mg implants are also believed to be anti-inflammatory and anti-osteoclastic, but this is difficult to reconcile with the early clinical inflammation observed around these implants. Here, by surveying implant healing in a rat bone model, we determined the cellular responses and structural assembly of bone correlated with the surface changes of Mg implants inherent in degradation. We show that, compared to titanium, both high-purity (99.998%) and clinical-grade, rare earth-alloyed (MgYREZr) Mg implants create an initial, transient proinflammatory environment that facilitates inducible nitric oxide synthase-mediated macrophage polarization, osteoclastogenesis, and neoangiogenesis programs. While this immunomodulation subsequently reinforces reparative osteogenesis at the surface of both Mg implants, the faster degradation of high-purity Mg implants, but not MgYREZr implants, elicits a compositional alteration in the interfacial bone and a previously unknown proadipogenic response with persistent low-grade inflammation in the surrounding bone marrow. Beyond the need for rigorous tailoring of Mg implants, these data highlight the need to closely monitor osseointegration not only at the immediate implant surface but also in the peri-implant bone and adjacent bone marrow.$

#biomaterials #tissueengineering #regenerativemedicine

**Furqan Shah** @furqanshah@mstdn.science · Aug 30, 2024 *

Aug 30, 2024 *

Furqan Shah @furqanshah@mstdn.science

Magnesium implant degradation provides immunomodulatory and proangiogenic effects and attenuates peri-implant fibrosis in soft tissues"

https://doi.org/10.1016/j.bioactmat.2023.02.014

Implants made of magnesium (Mg) are increasingly employed in patients to achieve osteosynthesis while degrading in situ. Since Mg implants and Mg2+ have been suggested to possess anti-inflammatory properties, the clinically observed soft tissue inflammation around Mg implants is enigmatic. Here, using a rat soft tissue model and a 1–28 d observation period, we determined the temporo-spatial cell distribution and behavior in relation to sequential changes of pure Mg implant surface properties and Mg2+ release. Compared to nondegradable titanium (Ti) implants, Mg degradation exacerbated initial inflammation. Release of Mg degradation products at the tissue-implant interface, culminating at 3 d, actively initiated chemotaxis and upregulated mRNA and protein immunomodulatory markers, particularly inducible nitric oxide synthase and toll-like receptor-4 up to 6 d, yet without a cytotoxic effect. Increased vascularization was demonstrated morphologically, preceded by high expression of vascular endothelial growth factor. The transition to appropriate tissue repair coincided with implant surface enrichment of Ca and P and reduced peri-implant Mg2+ concentration. Mg implants revealed a thinner fibrous encapsulation compared with Ti. The detailed understanding of the relationship between Mg material properties and the spatial and time-resolved cellular processes provides a basis for the interpretation of clinical observations and future tailoring of Mg implants.

#biomaterials #tissueengineering #regenerativemedicine

**Beilstein-Institut** @BeilsteinInstitut@hessen.social · Aug 8, 2024

Aug 8, 2024

Beilstein-Institut @BeilsteinInstitut@hessen.social

Submission is still possible until August 31, 2024:
Thematic issue “#Nanomaterials for #BiomedicalApplications” edited by Muhammad Anwaar Nazeer, Seda Kizilel and Filippo Pierini in the #BJNANO :
https://www.beilstein-journals.org/bjnano/series/105?M=y
#DrugDelivery #GeneDelivery #Biosensing #Nanofibers #TissueEngineering
#DiamondOpenAccess

**Bose-Einstein-Kondensat** @MWNautilus · Jul 26, 2024

Jul 26, 2024

Bose-Einstein-Kondensat @MWNautilus

#mSLAb: An #OpenSource masked #stereolithography (#mSLA) #bioprinter:

-based on Phrozen Sonic Mini 4 K
-#Arduino-temperature control & #humidification of the printing chamber

https://doi.org/10.1016/j.ohx.2024.e00543
#DIYbio #lab #instruments #hydrogel #3Dprinting #TissueEngineering

**Scientific European** @ScientificEuropean@toot.community · Feb 7, 2024

Feb 7, 2024

Scientific European @ScientificEuropean@toot.community

3D Bioprinting Assembles Functional Human Brain Tissue for The First Time
Scientists have developed a 3D bioprinting platform that assembles functional human neural tissues............
#3Dbioprinting #Bioprinting #brain #neurons #TissueEngineering
Umesh Prasad

https://www.scientificeuropean.co.uk/technology/3d-bioprinting-assembles-functional-human-brain-tissue-for-the-first-time/

**Dr. Marie McNeely** @PhDMarie@qoto.org · Jan 8, 2024

Jan 8, 2024

Dr. Marie McNeely @PhDMarie@qoto.org

This week's new PBtS podcast episode features Dr. Claire Higgins! She discussed her research on tissue engineering and regenerative medicine, her passion for pottery, memorable trips to Kyoto, exciting recent research successes, and more! https://peoplebehindthescience.com/dr-claire-higgins/

#podcast #podcasts #scicomm

**Alan Kotok** @technewslit@journa.host · Sep 29, 2023

Sep 29, 2023

Alan Kotok @technewslit@journa.host

A company with a process to generate new thymus tissue for immune system functions is receiving a $37 million award from the government's health breakthrough agency.

https://sciencebusiness.technewslit.com/?p=45277

Science and Enterprise · Sep 29, 2023Biotech Thymus Tissue Process Gains ARPA-H FundingA company with a process to generate new thymus tissue for immune system functions is receiving a $37 million award from the government's health breakthrough agency.

#News #Press #Science

**Gonzalo** @gcordova@mastodon.social · Aug 24, 2023

Aug 24, 2023

Gonzalo @gcordova@mastodon.social

Just Published!

"Recellularization of Acellular Xeno Kidney Scaffold: An In Vivo Method to Generate Bioartificial Kidney"

https://link.springer.com/chapter/10.1007/5584_2023_785

SpringerLinkRecellularization of Acellular Xeno Kidney Scaffold: An In Vivo Method to Generate Bioartificial KidneyA significant hurdle for kidney tissue engineering is reproducing the complex three-dimensional structure of the kidney. In our study, a stepwise approach of generating a reproducible Xeno kidney scaffold from a goat kidney is described, which can be implanted and...

#RegenerativeMedicine #TissueEngineering

**Steve Dustcircle** @dustcircle@masto.ai · Aug 9, 2023

Aug 9, 2023

Steve Dustcircle @dustcircle@masto.ai

Capturing the #BrainTumor #Microenvironment with #TissueEngineering
https://www.the-scientist.com/news-opinion/capturing-the-brain-tumor-microenvironment-with-tissue-engineering-71244

The Scientist Magazine®Capturing the Brain Tumor Microenvironment with Tissue EngineeringResearchers built a 3D glioblastoma model to study therapeutic resistance and improve drug screening systems.

**University of Limerick** @UL@mastodon.ie · Apr 17, 2023

Apr 17, 2023

University of Limerick @UL@mastodon.ie

5 advances in tissue engineering you need to know about

Tissue engineering has potential to provide personalised healthcare, grow tissues & organs in the lab & reduce organ donor waiting lists, as UL's Dr Aleksandra Serafin explains:
https://www.rte.ie/brainstorm/2023/0414/1376940-advances-tissue-engineering-organ-donor-personalised-healthcare/

A photograph of a pipette filling glass beakers with a clear liquid in a research lab. The shot is taken from above showing only the tip of the pipette and the beakers below, which are lit with blue and pink lights

#StudyatUL #Healthcare #Engineering

**RicLevato** @RicLevato · Apr 3, 2023

Apr 3, 2023

RicLevato @RicLevato

Thanks for the warm welcome @Readily3D looking forward to more advances in the field!
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RT @Readily3D
We are excited to have Prof. @RicLevato join Readily3D’s scientific advisory board!

Welcome on board, Riccardo!
https://www.linkedin.com/feed/update/urn:li:activity:7048671663927762944

#tissueengineering #biofabrication #3dprinting
https://twitter.com/Readily3D/status/1642907811645464578

www.linkedin.comReadily3D on LinkedIn: #tissueengineering #biofabrication #3dprintingWe are excited to have Prof. Riccardo Levato join Readily3D’s scientific advisory board! Dr. Levato is Associate Professor of Translational Bioengineering and…