"The combined powers of the world’s most expansive intelligence apparatus could turn up no evidence the Wuhan Institute of Virology (WIV) had SARS-CoV-2, nor its progenitor, nor a backbone on which it could have been engineered, before the pandemic broke out. Nor could they find any evidence of a biosafety incident."
So the explanation that was always most likely--an animal virus naturally evolved to infect humans--continues to be the most likely.