Zoomers of the Sunshine Coast<p>Understanding Long COVID <br>Through CD8+ T Cell Responses</p><p>SARS-CoV-2-specific CD8+ T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over two years<br><a href="https://www.pnas.org/doi/10.1073/pnas.2411428121" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">pnas.org/doi/10.1073/pnas.2411</span><span class="invisible">428121</span></a></p><p>See Also: Mast Cell Activation Episode<br><a href="https://www.buzzsprout.com/2405788/episodes/15875307" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">buzzsprout.com/2405788/episode</span><span class="invisible">s/15875307</span></a></p><p><a href="https://mstdn.ca/tags/CD8" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CD8</span></a> <a href="https://mstdn.ca/tags/TCells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TCells</span></a> <a href="https://mstdn.ca/tags/LongCovid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>LongCovid</span></a> <a href="https://mstdn.ca/tags/Vaccines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Vaccines</span></a> <a href="https://mstdn.ca/tags/Study" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Study</span></a> <a href="https://mstdn.ca/tags/TwoYears" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TwoYears</span></a> <a href="https://mstdn.ca/tags/Immunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Immunity</span></a> #<a href="https://mstdn.ca/tags/Durability" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Durability</span></a></p><p><a href="https://www.buzzsprout.com/2405788/episodes/15952636" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">buzzsprout.com/2405788/episode</span><span class="invisible">s/15952636</span></a></p>
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#tcells
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Rhyothemis<p>today I watched:</p><p>How Alzheimer's mutates the immune system | nature video</p><p><a href="https://youtu.be/o_dbdhwNbig?si=P53kD4ckA45YXKRL" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">youtu.be/o_dbdhwNbig?si=P53kD4</span><span class="invisible">ckA45YXKRL</span></a></p><p>5 min. interview with David Gate on CXCR3 expressing peripheral T cells and Alzheimer disease.</p><p>~</p><p>I wonder if thiamine deficiency increases CXCR3 expression?</p><p><a href="https://zeroes.ca/tags/2dayIwatched" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>2dayIwatched</span></a> <a href="https://zeroes.ca/tags/Alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Alzheimers</span></a> <br><a href="https://zeroes.ca/tags/NeurodegenerativeDiseases" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NeurodegenerativeDiseases</span></a><br><a href="https://zeroes.ca/tags/Tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tcells</span></a> <a href="https://zeroes.ca/tags/BrainHealth" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>BrainHealth</span></a> <a href="https://zeroes.ca/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunology</span></a> <a href="https://zeroes.ca/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neuroscience</span></a></p>
Matt Willemsen<p>Surprise Discovery: Scientists Discover New Anti-Cancer Potential of Salt<br><a href="https://scitechdaily.com/surprise-discovery-scientists-discover-new-anti-cancer-potential-of-salt/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">scitechdaily.com/surprise-disc</span><span class="invisible">overy-scientists-discover-new-anti-cancer-potential-of-salt/</span></a> <a href="https://mastodon.social/tags/salt" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>salt</span></a> <a href="https://mastodon.social/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cancer</span></a> <a href="https://mastodon.social/tags/Tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tcells</span></a> <a href="https://mastodon.social/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Immunology</span></a></p>
preLights<p>Know your neighbours…🏘️</p><p>Spatial positioning determines tissue-resident memory T cell fate in the gut.</p><p>Marina Schernthanner covers work from Miguel Reina-Campos & colleagues. <a href="https://biologists.social/tags/preprint" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>preprint</span></a></p><p><a href="https://biologists.social/tags/preLight" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>preLight</span></a> ⬇️ 👀</p><p><a href="https://prelights.biologists.com/highlights/functional-diversity-of-memory-cd8-t-cells-is-spatiotemporally-imprinted-v2/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">prelights.biologists.com/highl</span><span class="invisible">ights/functional-diversity-of-memory-cd8-t-cells-is-spatiotemporally-imprinted-v2/</span></a> </p><p><a href="https://biologists.social/tags/biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>biology</span></a> <a href="https://biologists.social/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunology</span></a> <a href="https://biologists.social/tags/intestine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>intestine</span></a> <a href="https://biologists.social/tags/TCells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TCells</span></a> <a href="https://biologists.social/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bioinformatics</span></a> <a href="https://biologists.social/tags/transcriptomics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>transcriptomics</span></a></p>
PLOS Biology<p>Quality & longevity of CD4+ <a href="https://fediscience.org/tags/Tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tcells</span></a> change with age in mice. @AYatesGroup &co show that these cells have longer lifespans and become more quiescent when the organism ages, but these properties depend on cellular age, not on host age <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PLOSBiology</span></a> <a href="https://plos.io/46PBjgX" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="">plos.io/46PBjgX</span><span class="invisible"></span></a></p>
Matt Hodgkinson<p>"Viral persistence and sustained immune activation are linked to Long Covid."</p><p><a href="https://www.science.org/doi/10.1126/scitranslmed.adk3295" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">science.org/doi/10.1126/scitra</span><span class="invisible">nslmed.adk3295</span></a></p><p><a href="https://scicomm.xyz/tags/LongCOVID" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>LongCOVID</span></a> <a href="https://scicomm.xyz/tags/NotInYourHead" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NotInYourHead</span></a> <a href="https://scicomm.xyz/tags/SARSCov2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SARSCov2</span></a> <a href="https://scicomm.xyz/tags/Virology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Virology</span></a> <a href="https://scicomm.xyz/tags/ChronicDisease" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChronicDisease</span></a> <a href="https://scicomm.xyz/tags/ViralInfection" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ViralInfection</span></a> <a href="https://scicomm.xyz/tags/ViralRNA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ViralRNA</span></a> <a href="https://scicomm.xyz/tags/ImmuneCells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ImmuneCells</span></a> <a href="https://scicomm.xyz/tags/TCells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TCells</span></a> <a href="https://scicomm.xyz/tags/ViralPersistence" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ViralPersistence</span></a></p>
SIB Swiss Bioinformatics<p>“This study represents a significant scientific breakthrough, as it shifts the paradigm in the understanding of MHC Class II peptides and their recognition by CD4+ T cells.” </p><p>🥁 One of the <a href="https://mstdn.science/tags/SIBRemarkableOutputs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SIBRemarkableOutputs</span></a> 2023 👏 </p><p>👉 More: <a href="https://tinyurl.com/3ah98n3j" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="">tinyurl.com/3ah98n3j</span><span class="invisible"></span></a> </p><p><a href="https://mstdn.science/tags/machinelearning" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>machinelearning</span></a> <a href="https://mstdn.science/tags/Tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tcells</span></a> <a href="https://mstdn.science/tags/CancerResearch" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CancerResearch</span></a></p>
Lorraine<p><a href="https://abcnews.go.com/GMA/GMA3/video/unusual-cancers-emerged-after-pandemic-covid-blame-110932851" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">abcnews.go.com/GMA/GMA3/video/</span><span class="invisible">unusual-cancers-emerged-after-pandemic-covid-blame-110932851</span></a><br>SO CLOSE!!!<br>They’re so close to getting it😩<br>It’s inflammation🙄<br>It’s only the vulnerable🙄</p><p>There’s no excuse for this level of stupidity. NONE.</p><p>Saw a Tern post about 🚘accidents, & having been in one pretty crazy Vin Diesel one myself tipped off by a fender bender I didn’t fix months earlier… that metaphor analogy is something people will have to learn the hard way apparently</p><p>You can’t un-ring bells<br><a href="https://zeroes.ca/tags/turbocancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>turbocancer</span></a> <a href="https://zeroes.ca/tags/tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>tcells</span></a> <a href="https://zeroes.ca/tags/ImmuneDysregulation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ImmuneDysregulation</span></a> <br><a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CovidIsNotOver</span></a> <a href="https://zeroes.ca/tags/wearARespirator" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>wearARespirator</span></a></p>
Arjan Boltjes<p>" The insights derived from this analysis do not only support a CD19 CAR T cell-mediated reset of the memory B cell compartment, but also the parallel inhibition of the interferon signature<br>in <a href="https://mastodon.social/tags/monocytes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>monocytes</span></a> and <a href="https://mastodon.social/tags/Tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tcells</span></a> of <a href="https://mastodon.social/tags/SLE" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SLE</span></a> patients"</p><p><a href="https://insight.jci.org/articles/view/179433" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">insight.jci.org/articles/view/</span><span class="invisible">179433</span></a></p><p>Striking that this apparently works better in getting rid of certain memory <a href="https://mastodon.social/tags/Bcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Bcells</span></a> than anti-CD20 antibodies.</p><p><a href="https://mastodon.social/tags/scRNAseq" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>scRNAseq</span></a> <a href="https://mastodon.social/tags/TCR" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TCR</span></a> <a href="https://mastodon.social/tags/carTcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>carTcells</span></a> <a href="https://mastodon.social/tags/OpenAccess" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>OpenAccess</span></a> <a href="https://mastodon.social/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a></p>
Arjan Boltjes<p>Impressive new work by Moravec et al. in Nature Biotechnology, sadly not open source. "... a <a href="https://mastodon.social/tags/HighThroughput" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>HighThroughput</span></a> personalized <a href="https://mastodon.social/tags/TCR" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TCR</span></a> discovery pipeline ..." with which they "...identified dozens of CD4+ and CD8+ T-cell-derived TCRs with potent tumor reactivity, including TCRs that recognized patient-specific <a href="https://mastodon.social/tags/neoantigens" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neoantigens</span></a>."</p><p><a href="https://www.nature.com/articles/s41587-024-02210-6" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41587-024</span><span class="invisible">-02210-6</span></a></p><p><a href="https://mastodon.social/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cancer</span></a> <a href="https://mastodon.social/tags/tumour" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>tumour</span></a> <a href="https://mastodon.social/tags/Tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tcells</span></a><br><a href="https://mastodon.social/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a></p>
Technische Universität München<p>Researchers discovered that <a href="https://wisskomm.social/tags/tumors" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>tumors</span></a> use a messenger substance to influence <a href="https://wisskomm.social/tags/immunecells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunecells</span></a> in an early phase of the immune response. This could significantly improve <a href="https://wisskomm.social/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cancer</span></a> immunotherapies: <a href="http://go.tum.de/368607" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">http://</span><span class="">go.tum.de/368607</span><span class="invisible"></span></a></p><p><a href="https://wisskomm.social/tags/tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>tcells</span></a> <a href="https://wisskomm.social/tags/prostaglandin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>prostaglandin</span></a></p><p>📷A.Eckert</p>
AutisticMumTo3<p>New approach detects T cells in "cold" tumors, paves way for broader immunotherapy<br> <a href="https://www.news-medical.net/news/20240229/New-approach-detects-T-cells-in-cold-tumors-paves-way-for-broader-immunotherapy.aspx" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">news-medical.net/news/20240229</span><span class="invisible">/New-approach-detects-T-cells-in-cold-tumors-paves-way-for-broader-immunotherapy.aspx</span></a></p><p><a href="https://mastodon.social/tags/TCells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TCells</span></a><br><a href="https://mastodon.social/tags/Cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Cancer</span></a><br><a href="https://mastodon.social/tags/ColdTumors" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ColdTumors</span></a><br><a href="https://mastodon.social/tags/Tumors" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tumors</span></a><br><a href="https://mastodon.social/tags/Immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Immunotherapy</span></a> <br><a href="https://mastodon.social/tags/LaJollaInstituteForImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>LaJollaInstituteForImmunology</span></a><br><a href="https://mastodon.social/tags/Neoantigens" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Neoantigens</span></a></p>
AutisticMumTo3<p>Newborn T cells found to excel in immune defense<br> <a href="https://www.msn.com/en-gb/health/other/newborn-t-cells-found-to-excel-in-immune-defense/ar-BB1iPdkC?cvid=ccf7362250394fd3d915a83e6744c18d&ocid=winp2fptaskbarhover&ei=8" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">msn.com/en-gb/health/other/new</span><span class="invisible">born-t-cells-found-to-excel-in-immune-defense/ar-BB1iPdkC?cvid=ccf7362250394fd3d915a83e6744c18d&ocid=winp2fptaskbarhover&ei=8</span></a></p><p><a href="https://mastodon.social/tags/TCells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TCells</span></a><br><a href="https://mastodon.social/tags/Newborns" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Newborns</span></a></p>
Mast0b1t<p><span class="h-card" translate="no"><a href="https://norden.social/@kraweel65" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>kraweel65</span></a></span> <span class="h-card" translate="no"><a href="https://urbanists.social/@TransitBiker" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>TransitBiker</span></a></span> </p><p><a href="https://www.merckmanuals.com/professional/hematology-and-oncology/leukopenias/lymphocytopenia" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">merckmanuals.com/professional/</span><span class="invisible">hematology-and-oncology/leukopenias/lymphocytopenia</span></a></p><p>Uli, <a href="https://awscommunity.social/tags/SarsCoV2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SarsCoV2</span></a> permanently kills off <a href="https://awscommunity.social/tags/TCells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TCells</span></a>. With one or repeat infections, you can get <a href="https://awscommunity.social/tags/LongCovid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>LongCovid</span></a> as a result. By then, you are open to opportunistic infections.</p><p>Clean your indoor air with HEPA filters or a <a href="https://awscommunity.social/tags/CorsiRosenthalBox" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CorsiRosenthalBox</span></a>. Wear <a href="https://awscommunity.social/tags/N95" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>N95</span></a> respirators or better. 😷</p><p>Also see: <span class="h-card" translate="no"><a href="https://bird.makeup/users/dbdugger" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>dbdugger</span></a></span></p>
Technische Universität München<p>Researchers discovered that <a href="https://wisskomm.social/tags/Bcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Bcells</span></a> play an active role in teaching <a href="https://wisskomm.social/tags/Tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tcells</span></a> not to attack the body itself. If the "training" fails, <a href="https://wisskomm.social/tags/autoimmunediseases" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>autoimmunediseases</span></a> such as <a href="https://wisskomm.social/tags/neuromyelitis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neuromyelitis</span></a> optica can develop: <a href="http://go.tum.de/562972" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">http://</span><span class="">go.tum.de/562972</span><span class="invisible"></span></a></p><p><a href="https://wisskomm.social/tags/thymus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>thymus</span></a> <a href="https://wisskomm.social/tags/Neuroimmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Neuroimmunology</span></a></p><p>📷J. Böttcher, T. Korn</p>
Monika Wolkers<p>Please find below our most recent pre-print. We studied the role of the RNA binding protein ZFP36L2 in effector T cells and found how it regulated the production of IFNgamma in late T cell responses and continuous activation with tumor cells (in vitro/in vivo). Happy reading!</p><p><a href="https://www.biorxiv.org/content/10.1101/2024.02.09.579641v1.article-metrics" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">24.02.09.579641v1.article-metrics</span></a></p><p><a href="https://mstdn.science/tags/Tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tcells</span></a> <a href="https://mstdn.science/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunology</span></a> <a href="https://mstdn.science/tags/tumor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>tumor</span></a> <a href="https://mstdn.science/tags/rna_binding_proteins" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>rna_binding_proteins</span></a> <a href="https://mstdn.science/tags/cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cytokines</span></a></p>
nemo™ 🇺🇦<p>Bystander activated <a href="https://mas.to/tags/CD8" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CD8</span></a> <a href="https://mas.to/tags/Tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tcells</span></a> mediate <a href="https://mas.to/tags/neuropathology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neuropathology</span></a> during <a href="https://mas.to/tags/viral" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>viral</span></a> infection via antigen-independent <a href="https://mas.to/tags/cytotoxicity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cytotoxicity</span></a> </p><p><a href="https://www.nature.com/articles/s41467-023-44667-0" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41467-023</span><span class="invisible">-44667-0</span></a></p><p><a href="https://mas.to/tags/openaccess" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>openaccess</span></a> </p><p><a href="https://www.nature.com/articles/s41467-023-44667-0.pdf" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41467-023</span><span class="invisible">-44667-0.pdf</span></a></p>
Lorraine<p>Boy, I just pick the most random times to watch mainstream media news. It’s been months but caught this as soon as I turned it on</p><p>🤔They’re shocked..</p><p>You know who isn’t shocked? None of us who have been following what <a href="https://zeroes.ca/tags/Covid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Covid</span></a> does to <a href="https://zeroes.ca/tags/tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>tcells</span></a></p><p><a href="https://zeroes.ca/tags/KingCharles" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>KingCharles</span></a> has been known for decades for being obsessed w/organic farming & he is epitome of privilege. But this <a href="https://zeroes.ca/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cancer</span></a> Dx is not going to be connected with <a href="https://zeroes.ca/tags/saracov2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>saracov2</span></a> even though there’s a clear line</p>
PLOS Biology<p>>90% of <a href="https://fediscience.org/tags/TCR" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TCR</span></a> sequence diversity is generated by TdT-mediated nucleotide addition, but what is the benefit of TdT-altered TCRs? @MandlLab show that low-affinity <a href="https://fediscience.org/tags/Tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tcells</span></a> generated by TdT are important for curtailing chronic pathogen replication <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PLOSBiology</span></a> <a href="https://plos.io/3HJKOCl" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="">plos.io/3HJKOCl</span><span class="invisible"></span></a></p>
trendless<p><a href="https://www.lapresse.ca/actualites/covid-19/2024-02-01/covid-longue/les-lymphocytes-t4-sont-mis-en-cause-constate-une-equipe-de-recherche.php" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">lapresse.ca/actualites/covid-1</span><span class="invisible">9/2024-02-01/covid-longue/les-lymphocytes-t4-sont-mis-en-cause-constate-une-equipe-de-recherche.php</span></a></p><p>> study of 29 people treated for COVID-19 at the University Hospital of Nîmes, France. In the months following hospitalization, nineteen patients suffered from long COVID, while the other ten had no after-effects.</p><p>> the percentage of T4 lymphocytes engaged in a form of programmed cell death (apoptosis) was 37% in the long COVID group and 24% in the other group. By way of comparison, in healthy subjects, the percentage of T4 lymphocytes undergoing apoptosis is approximately 20%; this percentage is comparable to that of patients who have recovered well from their infection, but it is almost half that of patients who have had after-effects.</p><p><a href="https://zeroes.ca/tags/LongCovid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>LongCovid</span></a> <a href="https://zeroes.ca/tags/TCells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TCells</span></a></p>
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