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#structuralbiology

2 posts2 participants0 posts today
jobRxiv<p>Biochemistry and Structural Biology of RNA-protein Complexes<br>Yunsun Nam Laboratory </p><p>See the full job description on jobRxiv: <a href="https://jobrxiv.org/job/yunsun-nam-laboratory-27778-biochemistry-and-structural-biology-of-rna-protein-complexes/" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">jobrxiv.org/job/yunsun-nam-lab</span><span class="invisible">oratory-27778-biochemistry-and-structural-biology-of-rna-protein-complexes/</span></a></p><p><a href="https://mas.to/tags/biochemistry" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>biochemistry</span></a> <a href="https://mas.to/tags/CancerEpigenetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CancerEpigenetics</span></a> <a href="https://mas.to/tags/RNA" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>RNA</span></a> <a href="https://mas.to/tags/RNAproteininteractions" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>RNAproteininteractions</span></a> <a href="https://mas.to/tags/structuralbiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>structuralbiology</span></a> <a href="https://mas.to/tags/ScienceJobs" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ScienceJobs</span></a> <a href="https://mas.to/tags/hiring" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>hiring</span></a> <a href="https://mas.to/tags/research" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>research</span></a><br><a href="https://jobrxiv.org/job/yunsun-nam-laboratory-27778-biochemistry-and-structural-biology-of-rna-protein-complexes/?fsp_sid=1026" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">jobrxiv.org/job/yunsun-nam-lab</span><span class="invisible">oratory-27778-biochemistry-and-structural-biology-of-rna-protein-complexes/?fsp_sid=1026</span></a></p>
SBGrid<p>New Title Alert: AITom- an open-source platform for AI driven cellular electron cryo-tomography analysis.</p><p>Learn more here: <a href="https://xulabs.github.io/" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">xulabs.github.io/</span><span class="invisible"></span></a></p><p><a href="https://mstdn.science/tags/SBGrid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGrid</span></a> <a href="https://mstdn.science/tags/SBGridSoftware" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGridSoftware</span></a> <a href="https://mstdn.science/tags/StructuralBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>StructuralBiology</span></a></p>
SBGrid<p>Meharry Medical College Ph.D. candidate KeAndreya Morrison's highlight features a <span class="h-card" translate="no"><a href="https://mstdn.social/@Nature" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>Nature</span></a></span> Communications publication from the laboratory of Christopher D. Lima whose work helped to uncover how the cell’s nuclear gateway controls molecular traffic and regulate protein function, offering new insights into gene regulation and disease.</p><p>Read more here: <a href="https://medium.com/sbgrid-community-news/dual-role-of-the-nuclear-gatekeeper-47013dcb1b05" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">medium.com/sbgrid-community-ne</span><span class="invisible">ws/dual-role-of-the-nuclear-gatekeeper-47013dcb1b05</span></a></p><p><a href="https://mstdn.science/tags/SBGrid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGrid</span></a> <a href="https://mstdn.science/tags/CryoEM" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CryoEM</span></a> <a href="https://mstdn.science/tags/StructuralBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>StructuralBiology</span></a></p>
SBGrid<p>SBGrid's eLife paper received a citation in July from Dhirendra Simanshu from Frederick National Laboratory for Cancer Research with collaborators in <span class="h-card" translate="no"><a href="https://flipboard.com/@SciMag" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>SciMag</span></a></span>: Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin.</p><p>Read more here: <a href="https://www.science.org/doi/abs/10.1126/science.adr9097?utm_source=AdaptiveMailer&amp;utm_medium=email&amp;utm_campaign=SBGrid%20Newsletters&amp;org=1935&amp;lvl=100&amp;ite=564&amp;lea=37746&amp;ctr=0&amp;par=1&amp;trk=a0NNv000000rbuHMAQ" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">science.org/doi/abs/10.1126/sc</span><span class="invisible">ience.adr9097?utm_source=AdaptiveMailer&amp;utm_medium=email&amp;utm_campaign=SBGrid%20Newsletters&amp;org=1935&amp;lvl=100&amp;ite=564&amp;lea=37746&amp;ctr=0&amp;par=1&amp;trk=a0NNv000000rbuHMAQ</span></a></p><p><a href="https://mstdn.science/tags/SBGrid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGrid</span></a> <a href="https://mstdn.science/tags/StructuralBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>StructuralBiology</span></a></p>
SBGrid<p>Caltech doctoral student Vida Robertson highlighted a new IUCrJ article from SBGrid member Nikolaus Grigorieff that describes an in situ structure of the ribosome determined using knife cut cellular sections.</p><p>Read more here: <a href="https://medium.com/sbgrid-community-news/the-cutting-edge-of-cellular-microscopy-6d995d99e050" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">medium.com/sbgrid-community-ne</span><span class="invisible">ws/the-cutting-edge-of-cellular-microscopy-6d995d99e050</span></a></p><p><a href="https://mstdn.science/tags/SBGrid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGrid</span></a> <a href="https://mstdn.science/tags/StructuralBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>StructuralBiology</span></a> <a href="https://mstdn.science/tags/ScienceMatters" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ScienceMatters</span></a></p>
SBGrid<p>The focus of our July member tale is Emina Stojković. She spoke with us from Northeastern Illinois University in Chicago where she has resumed marathon training. Today Stojković is exploring new frontiers in photoreception and signaling while seeking new opportunities to advance the careers of her undergraduate and master students after three NIH grant terminations.</p><p>Read more here: <a href="https://medium.com/sbgrid-community-news/drawn-to-the-light-258847d08e64" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">medium.com/sbgrid-community-ne</span><span class="invisible">ws/drawn-to-the-light-258847d08e64</span></a></p><p><a href="https://mstdn.science/tags/SBGridTales" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGridTales</span></a> <a href="https://mstdn.science/tags/StructuralBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>StructuralBiology</span></a> <a href="https://mstdn.science/tags/StayConnected" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>StayConnected</span></a></p>
SBGrid<p>New Title Alert: VirtualIce- a feature-rich half-synthetic cryoEM micrograph generator that uses buffer cryoEM micrographs with junk and carbon masked out as real background.</p><p>Learn more here: <a href="https://github.com/alexjnoble/VirtualIce" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">github.com/alexjnoble/VirtualI</span><span class="invisible">ce</span></a></p><p><a href="https://mstdn.science/tags/SBGrid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGrid</span></a> <a href="https://mstdn.science/tags/SBGridSoftware" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGridSoftware</span></a> <a href="https://mstdn.science/tags/StructuralBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>StructuralBiology</span></a></p>
SBGrid<p>New Title Alert: RareFold- a tool for the structure prediction and design of proteins that include non-canonical amino acids.</p><p>Learn more here: <a href="https://github.com/patrickbryant1/RareFold" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">github.com/patrickbryant1/Rare</span><span class="invisible">Fold</span></a></p><p><a href="https://mstdn.science/tags/SBGrid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGrid</span></a> <a href="https://mstdn.science/tags/SBGridSoftware" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGridSoftware</span></a> <a href="https://mstdn.science/tags/StructuralBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>StructuralBiology</span></a></p>
jobRxiv<p>Biochemistry and Structural Biology of RNA-protein Complexes<br>Yunsun Nam Laboratory </p><p>See the full job description on jobRxiv: <a href="https://jobrxiv.org/job/yunsun-nam-laboratory-27778-biochemistry-and-structural-biology-of-rna-protein-complexes/" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">jobrxiv.org/job/yunsun-nam-lab</span><span class="invisible">oratory-27778-biochemistry-and-structural-biology-of-rna-protein-complexes/</span></a></p><p><a href="https://mas.to/tags/biochemistry" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>biochemistry</span></a> <a href="https://mas.to/tags/CancerEpigenetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CancerEpigenetics</span></a> <a href="https://mas.to/tags/RNA" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>RNA</span></a> <a href="https://mas.to/tags/RNAproteininteractions" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>RNAproteininteractions</span></a> <a href="https://mas.to/tags/structuralbiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>structuralbiology</span></a> <a href="https://mas.to/tags/ScienceJobs" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ScienceJobs</span></a> <a href="https://mas.to/tags/hiring" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>hiring</span></a> <a href="https://mas.to/tags/research" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>research</span></a><br><a href="https://jobrxiv.org/job/yunsun-nam-laboratory-27778-biochemistry-and-structural-biology-of-rna-protein-complexes/?fsp_sid=494" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">jobrxiv.org/job/yunsun-nam-lab</span><span class="invisible">oratory-27778-biochemistry-and-structural-biology-of-rna-protein-complexes/?fsp_sid=494</span></a></p>
SBGrid<p>New Title Alert: RosEM- a tool that provides easy access to the rosetta cryoem refinement protocol. The pipeline automates testing of different density weights, use of reference/starting model restraints and selections.</p><p>Learn more here: <a href="https://github.com/fmi-basel/RosEM" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">github.com/fmi-basel/RosEM</span><span class="invisible"></span></a></p><p><a href="https://mstdn.science/tags/SBGrid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGrid</span></a> <a href="https://mstdn.science/tags/SBGridSoftware" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGridSoftware</span></a> <a href="https://mstdn.science/tags/StructuralBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>StructuralBiology</span></a></p>
Itamar Kass :protein:<p>🧬 New paper in @NaturePortfolio Scientific Reports!<br>We discovered how ZnT1 regulates cellular zinc transport through a novel "scissor-like" conformational mechanism.<br>My contribution: molecular dynamics simulations revealing the atomic-level dynamics.<br>Opens new therapeutic avenues for zinc-related disorders!<br>Great collaboration with the amazing team at @BenGurionU! 🔬<br><a href="https://www.nature.com/articles/s41598-025-07351-5" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41598-025</span><span class="invisible">-07351-5</span></a><br><a href="https://tooot.im/tags/MolecularDynamics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MolecularDynamics</span></a> <a href="https://tooot.im/tags/StructuralBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>StructuralBiology</span></a></p>
SBGrid<p>New Title Alert: LigandMPNN- a deep learning-based tool for designing protein sequences conditioned on atomic context, including ligands, DNA, RNA, and modified amino acids.</p><p>Learn more here: <a href="https://github.com/dauparas/LigandMPNN" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">github.com/dauparas/LigandMPNN</span><span class="invisible"></span></a></p><p><a href="https://mstdn.science/tags/SBGrid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGrid</span></a> <a href="https://mstdn.science/tags/SBGridSoftware" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGridSoftware</span></a> <a href="https://mstdn.science/tags/StructuralBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>StructuralBiology</span></a></p>
SBGrid<p>New Title Alert: CryoTransformer- a powerful and accurate particle-picking framework using Residual Network (ResNet) and Transformer.</p><p>Learn more here: <a href="https://github.com/jianlin-cheng/CryoTransformer/tree/main" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">github.com/jianlin-cheng/CryoT</span><span class="invisible">ransformer/tree/main</span></a></p><p><a href="https://mstdn.science/tags/SBGrid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGrid</span></a> <a href="https://mstdn.science/tags/SBGridSoftware" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGridSoftware</span></a> <a href="https://mstdn.science/tags/StructuralBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>StructuralBiology</span></a></p>
SBGrid<p>New Title Alert: GetContacts- a tool designed to dissect and visualize molecular interactions in proteins from various sources, including experimental structures (X-ray, NMR, Cryo-EM) and MD simulations.</p><p>Learn more here: <a href="https://getcontacts.github.io/index.html" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">getcontacts.github.io/index.ht</span><span class="invisible">ml</span></a></p><p><a href="https://mstdn.science/tags/SBGrid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGrid</span></a> <a href="https://mstdn.science/tags/SBGridSoftware" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGridSoftware</span></a> <a href="https://mstdn.science/tags/StructuralBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>StructuralBiology</span></a></p>
SBGrid<p>New Title Alert: Tomcat- a web-based tool designed for cataloging and managing tomography data providing an easy way to view, annotate, and organize tomograms.</p><p>Learn more here: <a href="https://github.com/shahpnmlab/tomcat" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">github.com/shahpnmlab/tomcat</span><span class="invisible"></span></a></p><p><a href="https://mstdn.science/tags/SBGrid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGrid</span></a> <a href="https://mstdn.science/tags/SBGridSoftware" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SBGridSoftware</span></a> <a href="https://mstdn.science/tags/StructuralBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>StructuralBiology</span></a></p>
Keiran Rowell<p>Structure of an archaeal ribosome reveals a<br>divergent active site and hibernation factor | Nature Micro</p><p><a href="https://rdcu.be/ewZ3S" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">rdcu.be/ewZ3S</span><span class="invisible"></span></a></p><p>"Ribosomes translate mRNA into protein. Despite divergence in ribosome structure over the course of evolution, the catalytic site, known as the peptidyl transferase centre (PTC) is thought to be nearly universally conserved. Here we identify clades of archaea that have highly divergent ribosomal RNA sequences in the PTC."</p><p><a href="https://mastodon.social/tags/archea" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>archea</span></a> <a href="https://mastodon.social/tags/structuralbiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>structuralbiology</span></a> <a href="https://mastodon.social/tags/ribosome" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ribosome</span></a> <a href="https://mastodon.social/tags/cryoEM" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cryoEM</span></a></p>
SBGrid

SBGrid's eLife paper received a citation in June from Robert Stroud from University of California, San Francisco in @Nature Structural and Molecular Biology: Substrate recognition and allosteric regulation of synaptic vesicle glutamate transporter VGLUT2.

Read more here: nature.com/articles/s41594-025

NatureSubstrate recognition and allosteric regulation of synaptic vesicle glutamate transporter VGLUT2 - Nature Structural & Molecular BiologyGuided by a structure of VGLUT2 with substrate, Li et al. identify the mechanisms for selective substrate recognition, a role for lipid modification in limiting axonal dispersion and for the cytoplasmic gate in allosteric regulation by lumenal H+.
#SBGrid#StructuralBiology
SBGrid

SBGrid's eLife paper received a citation in June from Jeffrey Holt from Boston Children's Hospital, along with a host of other SBGrid member contributors including Tianmin Fu of The Ohio State University, Marcos Sotomayor from University of Chicago, and Shaun Rawson from Harvard Medical School, in Neuron: Structural and functional basis of mechanosensitive TMEM63 channelopathies.

Read more here: cell.com/neuron/abstract/S0896

#SBGrid#StructuralBiology
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