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Amelia Glazier<p>Hi <a href="https://biologists.social/tags/ScienceMastodon" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ScienceMastodon</span></a>! I am happy to share the final <a href="https://biologists.social/tags/ResearchHighlight" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ResearchHighlight</span></a> from Issue 18 of JCS. Song-Kun Shyue and colleagues at the Institute of Biomedical Sciences, Academia Sinica, Taiwan, unravel the upstream protein machinery required for ER-associated degradation (ERAD) of the crucial enzyme cyclooxygenase-2.<br><a href="https://biologists.social/tags/cellbiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cellbiology</span></a> <a href="https://biologists.social/tags/proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteostasis</span></a></p><p>Derlins and Surf4 work together to ERADicate COX-2<br><a href="https://journals.biologists.com/jcs/article/136/18/e136_e1804/330714/Derlins-and-Surf4-work-together-to-ERADicate-COX-2" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">journals.biologists.com/jcs/ar</span><span class="invisible">ticle/136/18/e136_e1804/330714/Derlins-and-Surf4-work-together-to-ERADicate-COX-2</span></a></p>
Christoph Handschin<p>New paper! Great collaboration between our group and the <span class="h-card"><a href="https://mstdn.science/@mz" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>mz</span></a></span> at <span class="h-card"><a href="https://mstdn.science/@biozentrum" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>biozentrum</span></a></span> <span class="h-card"><a href="https://mstdn.social/@unibasel" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>unibasel</span></a></span> - supported by a Sinergia grant of the <span class="h-card"><a href="https://social.anoxinon.de/@snsf_ch" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>snsf_ch</span></a></span>.</p><p>Aberrant <a href="https://fediscience.org/tags/proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteostasis</span></a> (balance between protein synthesis and degradation, centrally regulated by <a href="https://fediscience.org/tags/mTOR" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>mTOR</span></a>) and mitochondrial dysfunction are two of the most prominent and reproducible processes associated with <a href="https://fediscience.org/tags/aging" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>aging</span></a> in skeletal <a href="https://fediscience.org/tags/muscle" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>muscle</span></a> (and other tissues).</p><p>1/2</p><p><a href="https://www.pnas.org/doi/10.1073/pnas.2302360120" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">pnas.org/doi/10.1073/pnas.2302</span><span class="invisible">360120</span></a></p>
jobRxiv<p>Postdoctoral Research Fellow in Proteostasis and Aging </p><p>UNC Charlotte</p><p>Postdoctoral research position available to study gut-to-muscle stress signaling and its role in aging <a href="https://mas.to/tags/chaperones" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>chaperones</span></a> <a href="https://mas.to/tags/Proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Proteostasis</span></a> <a href="https://mas.to/tags/C" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>C</span></a>. elegans</p><p>See the full job description on jobRxiv: <a href="https://jobrxiv.org/job/unc-charlotte-27778-postdoctoral-research-fellow-in-proteostasis-and-aging/?feed_id=54832" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">jobrxiv.org/job/unc-charlotte-</span><span class="invisible">27778-postdoctoral-research-fellow-in-proteostasis-and-aging/?feed_id=54832</span></a></p><p><a href="https://mas.to/tags/ScienceJobs" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ScienceJobs</span></a> ...<br><a href="https://jobrxiv.org/job/unc-charlotte-27778-postdoctoral-research-fellow-in-proteostasis-and-aging/?feed_id=54832" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">jobrxiv.org/job/unc-charlotte-</span><span class="invisible">27778-postdoctoral-research-fellow-in-proteostasis-and-aging/?feed_id=54832</span></a></p>
jobRxiv<p>PhD in Ubiquitin and Immune Signalling </p><p>RWTH Aachen University</p><p>PhD to study cross-talk between receptor-triggered and ubiquitin signalling in plants <a href="https://mas.to/tags/proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteostasis</span></a> <a href="https://mas.to/tags/PlantSci" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PlantSci</span></a> <a href="https://mas.to/tags/PlantSciJobs" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PlantSciJobs</span></a></p><p>See the full job description on jobRxiv: <a href="https://jobrxiv.org/job/rwth-aachen-university-27778-phd-in-ubiquitin-and-immune-signalling/?feed_id=52601" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">jobrxiv.org/job/rwth-aachen-un</span><span class="invisible">iversity-27778-phd-in-ubiquitin-and-immune-signalling/?feed_id=52601</span></a></p><p><a href="https://mas.to/tags/ScienceJobs" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ScienceJobs</span></a> <a href="https://mas.to/tags/hiring" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>hiring</span></a> <a href="https://mas.to/tags/research" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>research</span></a> <br>Aachen <a href="https://mas.to/tags/Germany" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Germany</span></a> <a href="https://mas.to/tags/P" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>P</span></a>...<br><a href="https://jobrxiv.org/job/rwth-aachen-university-27778-phd-in-ubiquitin-and-immune-signalling/?feed_id=52601" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">jobrxiv.org/job/rwth-aachen-un</span><span class="invisible">iversity-27778-phd-in-ubiquitin-and-immune-signalling/?feed_id=52601</span></a></p>
Kurianlab<p>Check out the latest paper from my buddy @TheVilchezLab on aging. The third paper today from my smart friends! V r doing well. <br>---<br>RT @TheVilchezLab<br>New work from the lab @NatureAging!❄️Lowering body temperature extends <a href="https://sciencemastodon.com/tags/longevity" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>longevity</span></a>. We find that cold-induced <a href="https://sciencemastodon.com/tags/proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteostasis</span></a> prevents <a href="https://sciencemastodon.com/tags/aging" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>aging</span></a> and aggregation of proteins that cause age-related diseases <a href="https://sciencemastodon.com/tags/ALS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ALS</span></a> <a href="https://sciencemastodon.com/tags/HuntingtonDisease" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>HuntingtonDisease</span></a> in C. elegans and human cells <a href="https://www.nature.com/articles/s43…" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="">nature.com/articles/s43…</span><span class="invisible"></span></a><br><a href="https://twitter.com/TheVilchezLab/status/1642908783327207426" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">twitter.com/TheVilchezLab/stat</span><span class="invisible">us/1642908783327207426</span></a></p>
Pablo J. Sáez :verified:<p>Another neat worskhop @DGZ_info, talks by @IgnatovaLab @FranziskaOttens @_ilgink @TheVilchezLab.</p><p>I loved the story ER associated degradation &amp; the "smurf assay" in <a href="https://mstdn.science/tags/celegans" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>celegans</span></a> by @Soto_Ef @FranziskaOttens, Shutter, et al.</p><p>Full: <a href="https://www.nature.com/articles/s41556-022-01025-4" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41556-022</span><span class="invisible">-01025-4</span></a> <a href="https://mstdn.science/tags/ER_literature" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ER_literature</span></a> <a href="https://mstdn.science/tags/scicomm" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>scicomm</span></a> <br>---<br>RT @DGZ_info<br>Join us for the next <a href="https://mstdn.science/tags/DGZ" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>DGZ</span></a> Focus Workshop on Cellular and Organismal <a href="https://mstdn.science/tags/Proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Proteostasis</span></a> on March 28, featuring @_ilgink, @TheVil…<br><a href="https://twitter.com/DGZ_info/status/1633025784968359943" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">twitter.com/DGZ_info/status/16</span><span class="invisible">33025784968359943</span></a></p>
jobRxiv<p>Postdoc position in Biology of Aging at NUS (Sorrentino lab) @Vinz_Sorrentino</p><p>My lab is opening position for <a href="https://mas.to/tags/postdoc" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>postdoc</span></a> at NUS in <a href="https://mas.to/tags/biology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>biology</span></a> of <a href="https://mas.to/tags/aging" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>aging</span></a>, <a href="https://mas.to/tags/mitochondria" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>mitochondria</span></a>, <a href="https://mas.to/tags/proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteostasis</span></a> <a href="https://mas.to/tags/translationalresearch" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>translationalresearch</span></a><br> <a href="http://lnkd.in/gcVu3m_R" rel="nofollow noopener" target="_blank"><span class="invisible">http://</span><span class="">lnkd.in/gcVu3m_R</span><span class="invisible"></span></a></p><p>...<br><a href="https://jobrxiv.org/job/national-university-of-singapore-centre-for-healthy-longevity-27778-postdoc-position-in-biology-of-aging-at-nus-sorrentino-lab/?feed_id=41436" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">jobrxiv.org/job/national-unive</span><span class="invisible">rsity-of-singapore-centre-for-healthy-longevity-27778-postdoc-position-in-biology-of-aging-at-nus-sorrentino-lab/?feed_id=41436</span></a></p>
Andy Truman PhD<p>We now have an official departmental page for the Charlotte Group for Proteostasis Research (biology.charlotte.edu/research/prote…)! Keep an eye out for possible opportunities to join us in the future 😀 <a href="https://mastodon.social/tags/proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteostasis</span></a> <a href="https://mastodon.social/tags/chaperones" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>chaperones</span></a> @UNCCBiology</p>
Biology Open<p>Maximilian A. Thompson and Evandro A. De-Souza review recent advances in the intersection of <a href="https://mstdn.science/tags/proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteostasis</span></a> and <a href="https://mstdn.science/tags/aging" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>aging</span></a>, with a particular focus on new understanding of how cells communicate with each other during <a href="https://mstdn.science/tags/proteotoxic" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteotoxic</span></a> stress. <a href="https://mstdn.science/tags/Review" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Review</span></a> 🔍 <a href="https://mstdn.science/tags/OpenAccess" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>OpenAccess</span></a> 🔐 </p><p><a href="https://journals.biologists.com/bio/article/12/2/bio059750/287042/A-Year-at-the-Forefront-of-Proteostasis-and-Aging" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">journals.biologists.com/bio/ar</span><span class="invisible">ticle/12/2/bio059750/287042/A-Year-at-the-Forefront-of-Proteostasis-and-Aging</span></a></p><p><a href="https://mstdn.science/tags/Biology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Biology</span></a> <a href="https://mstdn.science/tags/Science" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Science</span></a> <a href="https://mstdn.science/tags/BiologyOpen" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>BiologyOpen</span></a> <a href="https://mstdn.science/tags/AcademicMastodon" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>AcademicMastodon</span></a></p>
jobRxiv<p>Postdoc position in Biology of Aging at NUS (Sorrentino lab) @Vinz_Sorrentino</p><p>My lab is opening position for <a href="https://mas.to/tags/postdoc" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>postdoc</span></a> at NUS in <a href="https://mas.to/tags/biology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>biology</span></a> of <a href="https://mas.to/tags/aging" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>aging</span></a>, <a href="https://mas.to/tags/mitochondria" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>mitochondria</span></a>, <a href="https://mas.to/tags/proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteostasis</span></a> <a href="https://mas.to/tags/translationalresearch" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>translationalresearch</span></a><br> <a href="http://lnkd.in/gcVu3m_R" rel="nofollow noopener" target="_blank"><span class="invisible">http://</span><span class="">lnkd.in/gcVu3m_R</span><span class="invisible"></span></a></p><p>...<br><a href="https://jobrxiv.org/job/national-university-of-singapore-centre-for-healthy-longevity-27778-postdoc-position-in-biology-of-aging-at-nus-sorrentino-lab/?feed_id=39666" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">jobrxiv.org/job/national-unive</span><span class="invisible">rsity-of-singapore-centre-for-healthy-longevity-27778-postdoc-position-in-biology-of-aging-at-nus-sorrentino-lab/?feed_id=39666</span></a></p>
jobRxiv<p>Postdoc position in Biology of Aging at NUS (Sorrentino lab) @Vinz_Sorrentino</p><p>My lab is opening position for <a href="https://mas.to/tags/postdoc" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>postdoc</span></a> at NUS in <a href="https://mas.to/tags/biology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>biology</span></a> of <a href="https://mas.to/tags/aging" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>aging</span></a>, <a href="https://mas.to/tags/mitochondria" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>mitochondria</span></a>, <a href="https://mas.to/tags/proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteostasis</span></a> <a href="https://mas.to/tags/translationalresearch" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>translationalresearch</span></a><br> <a href="http://lnkd.in/gcVu3m_R" rel="nofollow noopener" target="_blank"><span class="invisible">http://</span><span class="">lnkd.in/gcVu3m_R</span><span class="invisible"></span></a></p><p>...<br><a href="https://jobrxiv.org/job/national-university-of-singapore-centre-for-healthy-longevity-27778-postdoc-position-in-biology-of-aging-at-nus-sorrentino-lab/?feed_id=39486" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">jobrxiv.org/job/national-unive</span><span class="invisible">rsity-of-singapore-centre-for-healthy-longevity-27778-postdoc-position-in-biology-of-aging-at-nus-sorrentino-lab/?feed_id=39486</span></a></p>
Aging Highlights<p>A Year at the Forefront of Proteostasis and Aging </p><p><span class="h-card"><a href="https://mstdn.science/@Co_Biologists" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>Co_Biologists</span></a></span> <span class="h-card"><a href="https://mstdn.science/@BiologyOpen" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>BiologyOpen</span></a></span> </p><p><a href="https://mas.to/tags/review" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>review</span></a> <a href="https://mas.to/tags/aging" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>aging</span></a> <a href="https://mas.to/tags/proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteostasis</span></a> </p><p><a href="https://journals.biologists.com/bio/article/12/2/bio059750/287042/A-Year-at-the-Forefront-of-Proteostasis-and-Aging" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">journals.biologists.com/bio/ar</span><span class="invisible">ticle/12/2/bio059750/287042/A-Year-at-the-Forefront-of-Proteostasis-and-Aging</span></a></p>
Verena Kohler<p>Are you ready for your reading list for the week?</p><p>Check out this week's edition of publications on <a href="https://fediscience.org/tags/MembraneContactSites" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MembraneContactSites</span></a>!</p><p><a href="http://biomed.news/bims-mecosi/2023-01-29" rel="nofollow noopener" target="_blank"><span class="invisible">http://</span><span class="ellipsis">biomed.news/bims-mecosi/2023-0</span><span class="invisible">1-29</span></a></p><p>Thanks to <a href="https://fediscience.org/tags/BioMedNews" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>BioMedNews</span></a>, an abstract-selection tool based on <a href="https://fediscience.org/tags/ArtificialIntelligence" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ArtificialIntelligence</span></a> and <a href="https://fediscience.org/tags/MachineLearning" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MachineLearning</span></a>!</p><p><a href="https://fediscience.org/tags/MAMs" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MAMs</span></a> <a href="https://fediscience.org/tags/MCS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MCS</span></a> <a href="https://fediscience.org/tags/Mitochondria" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Mitochondria</span></a> <a href="https://fediscience.org/tags/Lysosome" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Lysosome</span></a> <a href="https://fediscience.org/tags/Proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Proteostasis</span></a></p>
Thiago Carvalho<p>"We have discovered the Caenorhabditis elegans homeodomain-interacting protein kinase (HPK-1) acts as a key transcriptional effector to preserve neuronal integrity, function, and <a href="https://qoto.org/tags/proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteostasis</span></a> during <a href="https://qoto.org/tags/aging" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>aging</span></a>."</p><p><a href="https://qoto.org/tags/Celegans" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Celegans</span></a> <a href="https://qoto.org/tags/preprint" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>preprint</span></a> </p><p><a href="https://www.biorxiv.org/content/10.1101/2023.01.11.523661v1" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">23.01.11.523661v1</span></a></p>
The EMBO Journal<p>What happens to the <a href="https://sciencemastodon.com/tags/ubiquitin" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ubiquitin</span></a>-<a href="https://sciencemastodon.com/tags/proteasome" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteasome</span></a> system in cells that cannot form <a href="https://sciencemastodon.com/tags/stressgranules" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>stressgranules</span></a>?<br>Nico Dantuma &amp; coworkers at Karolinska Institute find surprising <a href="https://sciencemastodon.com/tags/nucleolar" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>nucleolar</span></a> relocalization of DRiP <a href="https://sciencemastodon.com/tags/peptides" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>peptides</span></a>, compromising <a href="https://sciencemastodon.com/tags/proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteostasis</span></a> in the nucleus<br><a href="https://www.embopress.org/doi/10.15252/embj.2022111802" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">embopress.org/doi/10.15252/emb</span><span class="invisible">j.2022111802</span></a></p>
Aging Highlights<p>Intercellular Mitochondrial Transfer as a Rescue Mechanism in Response to Protein Import Failure</p><p><a href="https://mas.to/tags/mitochondria" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>mitochondria</span></a> <a href="https://mas.to/tags/proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteostasis</span></a> <a href="https://mas.to/tags/preprint" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>preprint</span></a> </p><p><a href="https://www.biorxiv.org/content/10.1101/2022.11.30.518494v2" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">22.11.30.518494v2</span></a></p>
Verena Kohler<p><a href="https://fediscience.org/tags/Introduction" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Introduction</span></a>:</p><p>Hello <a href="https://fediscience.org/tags/ScienceMastodon" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ScienceMastodon</span></a>.</p><p>My name is Verena Kohler and I am a <a href="https://fediscience.org/tags/FirstGen" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>FirstGen</span></a> <a href="https://fediscience.org/tags/scientist" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>scientist</span></a>, currently working as independent senior <a href="https://fediscience.org/tags/postdoc" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>postdoc</span></a> at <a href="https://fediscience.org/tags/UniGraz" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>UniGraz</span></a> in Austria. </p><p>I am interested, how age influences <a href="https://fediscience.org/tags/proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteostasis</span></a>, the balance between protein production, folding and degradation, and how <a href="https://fediscience.org/tags/ageing" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ageing</span></a> affects cellular <a href="https://fediscience.org/tags/communication" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>communication</span></a> routes.<br>For that, I am using my favourite <a href="https://fediscience.org/tags/ModelOrganism" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ModelOrganism</span></a>, the baker’s <a href="https://fediscience.org/tags/yeast" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>yeast</span></a>, a lot of <a href="https://fediscience.org/tags/FluorescenceMicroscopy" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>FluorescenceMicroscopy</span></a> and <a href="https://fediscience.org/tags/HighThroughput" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>HighThroughput</span></a> screens.</p><p>Let’s talk <a href="https://fediscience.org/tags/science" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>science</span></a> !</p>
Aging Highlights<p>Shift of the insoluble content of the proteome in aging mouse brain</p><p><a href="https://mas.to/tags/proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteostasis</span></a> <a href="https://mas.to/tags/aging" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>aging</span></a> <a href="https://mas.to/tags/brain" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>brain</span></a> </p><p><a href="https://www.biorxiv.org/content/10.1101/2022.12.13.520290v1" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">22.12.13.520290v1</span></a></p>
TheVilchezLab<p>I’m still not sure how this 🐘 works, but I guess the best is to start with an <a href="https://mastodon.online/tags/introduction" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>introduction</span></a> <br>Here I will be posting about stuff from our lab at the CECAD. We want to understand <a href="https://mastodon.online/tags/aging" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>aging</span></a> and <a href="https://mastodon.online/tags/proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteostasis</span></a> to prevent multiple age-related diseases such as <a href="https://mastodon.online/tags/ALS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ALS</span></a>, <a href="https://mastodon.online/tags/Alzheimer" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Alzheimer</span></a>, <a href="https://mastodon.online/tags/Parkinson" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Parkinson</span></a> and <a href="https://mastodon.online/tags/huntington" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>huntington</span></a></p>
Aging Highlights<p>Loss of MTCH-1 suppresses age-related proteostasis collapse through the inhibition of programmed cell death factors</p><p><a href="https://mas.to/tags/proteostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteostasis</span></a> <a href="https://mas.to/tags/Celegans" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Celegans</span></a> <a href="https://mas.to/tags/aging" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>aging</span></a> </p><p><a href="https://www.sciencedirect.com/science/article/pii/S2211124722015649" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">sciencedirect.com/science/arti</span><span class="invisible">cle/pii/S2211124722015649</span></a></p>