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#organicchemistry

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Although 1,3-acyl transpositions are well known, their 1,2 counterparts are more difficult to achieve. Richmond Sarpong and his group from Berkeley University () decided to use 2,3-dihydrobenzofuran, which can form a reactive cyclopropane intermediate upon UV irradiation. Addition of halogen could then trigger the opening of the cyclopropane, which was then attacked by the nucleophilic phenol, yielding the 1,2-acyl transferred product.

science.org/doi/epdf/10.1126/s

Diene-En Ring-Closing Metathesis poses challenges in regioselectivity and cis/trans selectivity. However, it can be effective, as demonstrated by Jin-Ming Gao and colleagues from Northwest A&F University (). They reported the total synthesis of ansatrienol K in the Journal of Organic Chemistry. This work is interesting for anyone focused on methods for polyketide synthesis.

pubs.acs.org/doi/full/10.1021/

So, I have a "World's Smallest Elf on the Shelf" figure at work. This little guy will be moving around my office for the season. Today, I found him hugging a double bond near a carbon atom on my caffeine model. Happy Wednesday! #ElfOnTheShelf #Silly #Santa #Elf #ParentingMemes #ParentingMeme #Photo #Photograh #Christmas #Caffeine #Chemistry #MolecularModel #OrganicChemistry #ChemistryLove #Organic #MolecularModelKit #Chemist #OrganicChemistryMolecularKit #MolecularKit #OChem #Toy #Toys

The folks @Wikipedia have reminded the global #chemistry community that German chemist, and (too?) longtime editor of the Journal für Praktische Chemie, Hermann Kolbe died OTD in 1884. His Wikipedia article lists his impressive accomplishments in #OrganicChemistry. en.m.wikipedia.org/wiki/Herman

For non-chemists reading his #Wikipedia article, it ends with this head-scratcher: “The violence of his language worked to limit his posthumous reputation.”

Explanation: umsl.edu/~fraundorfp/simplify/

en.m.wikipedia.orgHermann Kolbe - Wikipedia