Gregory MS<p><a href="https://gregory-ms.com/articles/299503/?utm_source=mastodon&utm_medium=article&term=299503" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299503</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299503</span></a></p><p>The administration of human monoclonal antibodies (mAbs) in preclinical pharmacokinetics and toxicology studies often triggers an immune response, leading to the formation of anti-drug antibodies (ADA). To mitigate this effect, we have recently performed studies using short-term immunosuppressive regimens to induce prolonged immune tolerance towards a human Ab, erenumab, in rats. We report on t...</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
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#multiplesclerosis
133 posts · 11 participants · 6 posts today
Gregory MS<p><a href="https://gregory-ms.com/articles/299504/?utm_source=mastodon&utm_medium=article&term=299504" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299504</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299504</span></a></p><p>Vitamin D deficiency is an established risk factor for multiple sclerosis (MS). Lower vitamin D serum levels are associated with worse disease outcomes. A 4-year observational study was conducted to evaluate the association between vitamin D supplementation and disease progression in 132 relapsing-remitting MS patients. After 36 months, a significant increase in atrophy was observed in both gro...</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/299403/?utm_source=mastodon&utm_medium=article&term=299403" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299403</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299403</span></a></p><p>Human olfactory ecto-mesenchymal stem cells (OEMSC) have potential for the treatment of peripheral nerve injury through the secretion of bioactive factors. The current research investigates the therapeutic effects of a venous bridge filled with freshly purified or cryoconserved OEMSC-derived EVs after a peroneal nerve loss of substance. Three months after surgery, nerve repair was analyzed by m...</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/299404/?utm_source=mastodon&utm_medium=article&term=299404" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299404</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299404</span></a></p><p>Asphyxia of the newborn can cause hypoxic-ischemic encephalopathy. HIF-1a signaling is involved in the pathophysiology of neural tissue after asphyxia. The study mimicked the injury to cultured oligodendrocyte progenitor cells from rat pups.</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/299442/?utm_source=mastodon&utm_medium=article&term=299442" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299442</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299442</span></a></p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/299461/?utm_source=mastodon&utm_medium=article&term=299461" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299461</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299461</span></a></p><p>Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system. T-lymphocytes and proinflammatory interleukin 17A (IL-17A) are implicated in the pathogenesis of the disease. Beta adrenergic receptor blockade significantly attenuated EAE disease severity and animal weight loss. Therapeutic pharmacological blockade of beta adrenergic receptors with either propranolol (lipophilic)...</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/299351/?utm_source=mastodon&utm_medium=article&term=299351" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299351</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299351</span></a></p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/299370/?utm_source=mastodon&utm_medium=article&term=299370" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299370</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299370</span></a></p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/299387/?utm_source=mastodon&utm_medium=article&term=299387" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299387</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299387</span></a></p><p>Malaria remains a significant public health challenge in Brazil. Plasmodium vivax is the predominant species. Dysregulated immune responses contribute to malaria pathogenesis. In this study, peripheral blood mononuclear cells (PBMCs) were stimulated in vitro with P.vivax-infected erythrocyte (Pv-iE) lysate to assess IDO-1 expression, KYN&<a href="https://mastodon.social/tags/x2F" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>x2F</span></a>;TRP ratio, cytokine production, and T</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/299397/?utm_source=mastodon&utm_medium=article&term=299397" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299397</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299397</span></a></p><p>Methylated CpG oligodeoxynucleotides (ODN) from Bifidobacterium longum subsp. infantis have immunomodulatory effects through the induction of regulatory T cells. Methylated ODN-A (2m-V1), ODn-B (um-V2), ODN C (2 m’-V3) and ODN D (3 m&#39;-V4) markedly reduce</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/299314/?utm_source=mastodon&utm_medium=article&term=299314" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299314</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299314</span></a></p><p>Targeting retinoic acid-related orphan receptor γ (RORγ) with inverse agonists presents a promising therapeutic strategy for treating autoimmune diseases, including psoriasis, rheumatoid arthritis, and multiple sclerosis.</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/299319/?utm_source=mastodon&utm_medium=article&term=299319" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299319</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299319</span></a></p><p>Clonus is a disabling symptom of upper motor neuron dysfunction in patients with multiple sclerosis (MS). We report immediate termination of mechanically evoked clonus by epidural lumbosacral spinal cord</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/299320/?utm_source=mastodon&utm_medium=article&term=299320" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299320</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299320</span></a></p><p>There is a significant unmet need for effective treatments for chronic neuropathic pain. Baicalein (BA) is a flavonoid compound extracted from Scutellaria baicalensis. It has anti-inflammatory, antibacterial, and anti-proliferative activities against tumor cells. BA alleviated SNI-induced hyperalgesia and the progression of chronic pain.</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/299324/?utm_source=mastodon&utm_medium=article&term=299324" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299324</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299324</span></a></p><p>Mesenchymal stem cell-derived extracellular vesicles are rich in bioactive substances and have potential in the treatment of neurodegenerative diseases. Their vesicular structure can penetrate the blood–brain barrier and modulate the activity of microglia and astrocytes by delivering functional molecules.</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/299327/?utm_source=mastodon&utm_medium=article&term=299327" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299327</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299327</span></a></p><p>There is an increased concentration of proinflammatory cytokines in plasma, homogenates of the brain and spinal cord, serum circulating immune complexes, APO-1&<a href="https://mastodon.social/tags/x2F" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>x2F</span></a>;Fas, and glycosphingolipids during experimental autoimmune encephalomyelitis (EAE) and its treatment. Administration of the ganglioside-containing drug in vivo led to the normalization of the levels of the studied factors, demonstra...</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/299328/?utm_source=mastodon&utm_medium=article&term=299328" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299328</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299328</span></a></p><p>Tocilizumab showed significant efficacy in reducing annualized relapse rates and improved neurological outcomes in MOGAD patients. However, the existing data are limited to small, observational studies.</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/299341/?utm_source=mastodon&utm_medium=article&term=299341" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299341</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299341</span></a></p><p>SCFAs are products of gut microbiota through fermentation of soluble fibers. Recent studies have highlighted the beneficial roles of SCFAs in various physiological and pathological conditions, including diabetes. In this study, we applied streptozotocin (STZ) to mice with type 1 diabetes mellitus (T1DM) and found an increase in SCFA metabolism-related bacteria and improved hyperglycemia. The ex...</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/299345/?utm_source=mastodon&utm_medium=article&term=299345" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299345</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299345</span></a></p><p>Corticosteroid treatment of MS relapses is assumed to improve the speed of relapse recovery without modifying long-term disability risk. In a large cohort of people with MS, 32.7% reached the outcome of confirmed disability worsening over the study period. Non-treated relapses were associated with a higher risk of disability worsening.</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/299346/?utm_source=mastodon&utm_medium=article&term=299346" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299346</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299346</span></a></p><p>Ultrasound stimulation (FUS) is gaining attention as a non-invasive and highly precise neuromodulatory technique with broad therapeutic potential in neurological and psychiatric disorders. This study presents an innovative and thorough synthesis of FUS effects in in vitro neurological cell models. It highlights the importance of AI in directing real-time FUS targeting and optimizing parameters.</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/299241/?utm_source=mastodon&utm_medium=article&term=299241" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/299241</span><span class="invisible">/?utm_source=mastodon&utm_medium=article&term=299241</span></a></p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
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