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#LungDisease

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Enhancement of OVA-induced murine lung eosinophilia by co-exposure to contamination levels of #LPS in Asian sand #dust and heated dust

Yahao Ren, et al.
Published: 2014 Jun 9

"A previous study has shown that the aggravation of Asian sand dust (ASD) on ovalbumin (OVA)-induced lung eosinphilia was more severe in lipopolysaccharide (LPS)-rich ASD than in SiO2-rich ASD. Therefore, the effects of different LPS contamination levels in ASD on the aggravation of OVA-induced lung eosinophilia were investigated in the present study.

Conclusions:

"This study demonstrates that LPS contamination in ASD aggravates allergic lung inflammation in the presence of OVA and H-ASD. The aggravation of the allergic lung inflammation by LPS may be caused through the TLR4-dependent signaling pathway. The results of the current study indicate that the exposure to ASD with LPS may be a significant risk factor for adult and child #asthma. The hazardous effects of #MineralDust and #biogenic agents on human respiratory disease are an increasing public concern. Atmospheric exposure to #bacteria, fungi and virus, and silica-carrying particulate matters may influence human respiratory health on a world-wide scale."

ncbi.nlm.nih.gov/pmc/articles/

#DryingLakes #AgriculturalPollution
#Fertilizers #Phosphorus
#SaltonSea #Wildlife #HumanHealth #MonoLake #AralSea #GreatSaltLake #SaltonSea #LungDisease

PubMed Central (PMC)Enhancement of OVA-induced murine lung eosinophilia by co-exposure to contamination levels of LPS in Asian sand dust and heated dustA previous study has shown that the aggravation of Asian sand dust (ASD) on ovalbumin (OVA)-induced lung eosinphilia was more severe in lipopolysaccharide (LPS)-rich ASD than in SiO[2] -rich ASD. Therefore, the effects of different LPS contamination levels ...

At the #Salton Sea, Uncovering the Culprit of #LungDisease

Researchers may have found a cause for #asthma-like symptoms in the region. The discovery could have #global implications.

"The scientists are eager to see if the mice demonstrate a similar disease profile with Great Salt Lake dust. If they do, according to Yisrael, it could potentially have global implications. She points to areas like the #AralSea, on the border of #Kazakhstan and #Uzbekistan, as well as lake systems closer to home, like #MonoLake, in central California. 'All of these areas globally are drying up, and around these areas are communities which complain of severe asthma-like symptoms'"

By Fletcher Reveley
08.19.2024

"When David Lo first visited the Salton Sea shore in the spring of 2018, he was struck by the sheer oddness of the place: the beach of barnacle shells and pulverized fish bones; the abandoned dock far from the water’s edge; the unremitting smell of decay. It was like a scene from a science fiction movie, recalled the 66-year-old biomedical researcher from University of California, Riverside, familiar yet “just off of normal.”

But it was also pleasant, in a way. The sun glistened off the placid surface of the water, the Chocolate Mountains rose in the distance. At first, he said, 'all those odd parts don’t hit you in terms of potential, like ‘Oh my gosh this is a toxic, nasty sort of thing.' But for him that’s changed, he added, 'having learned more about what’s going on.'

"The Salton Sea is a 316-square mile, shallow glaze of water in #SouthernCalifornia that has been receding in recent years. Scientists believe the #ToxicDust kicked up from the exposed lakebed is contributing to respiratory disease in the region.

"Now, after nearly a decade of research, Lo recommends that anyone visiting the lake wear an #N95 mask. Something in the environment — in the water, the land, the air, or all three — appears to be making people in the region sick with a respiratory disease that presents like asthma. Children have been especially impacted; in some areas more than a quarter of kids have been diagnosed with asthma, more than four times the national childhood #asthma rate. Even more children, whether they have been diagnosed or not, display asthma-like symptoms — more than a third of kids in certain areas. And although residents of the area have long believed the Salton Sea to be toxic, Lo and other researchers at UC Riverside are only now beginning to zero in on a culprit. And it’s one that nobody expected."

[...]

"For Lo and the other researchers, however, the results were remarkable for a different reason — the geographic distribution of the asthma symptoms seemed to map closely onto the geographic distribution of the #LPS. The southern end of the lake was also the main entry point for #AgriculturalRunoff, which is laced with nutrients and feeds explosive biological activity. 'All these things are coming together,' said Lo. “The nutrients driving the bacterial growth, driving the toxin getting into the dust, driving the symptoms.' Lo recalled that at one meeting this year of the Salton Sea Task Force, a multidisciplinary group of UC Riverside scientists that studies the Salton Sea, the findings of the various threads of research began to converge: 'That was the meeting where everybody was, you know their jaws were dropping, like ‘Oh my gosh, it’s all fitting into place.’'"

[...]

"Near the end of May this year, Lo hosted a forum at UC Riverside on the health effects of dust and other particles that can be suspended in air. Many of the presenters were graduate students or faculty from various labs at UC Riverside that study the Salton Sea, but one of the keynote speakers, Molly Blakowski, had flown in from a different state entirely. Blakowski studies the Great Salt Lake, in Utah, and her invitation to the event reflected a growing concern among the UC Riverside investigators: What if this toxic LPS is not unique to the Salton Sea?

"In a recent interview with Undark, Blakowski drew parallels between the Salton Sea and the #GreatSaltLake — both are #hypersaline, terminal lakes that are rapidly shrinking; both contain areas where #nutrients from #agricultural activity enter and impact the #microbiome. Another similarity, she said, is that there are major knowledge gaps regarding the lake and its impact on human health." [NOT JUST HUMAN HEALTH!!!]

undark.org/2024/08/19/salton-s

Undark Magazine · At the Salton Sea, Uncovering the Culprit of Lung DiseaseResearchers may have found a cause for asthma-like symptoms in the region. The discovery could have global implications.

Modeled small airways lung deposition of two fixed-dose triple therapy combinations assessed with in silico functional respiratory imaging | Respiratory Research | Full Text respiratory-research.biomedcen

BioMed CentralModeled small airways lung deposition of two fixed-dose triple therapy combinations assessed with in silico functional respiratory imaging - Respiratory ResearchBackground Small airways disease plays a key role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and is a major cause of obstruction; therefore, it is a critical pharmacotherapy target. This study evaluated lung deposition of two inhaled corticosteroid (ICS)/long-acting β2-agonist/long-acting muscarinic antagonist single-inhaler triple therapies using in silico functional respiratory imaging (FRI). Deposition was assessed using real-world inhalation profiles simulating everyday use where optimal inhalation may be compromised. Methods Three-dimensional airway models were produced from 20 patients with moderate-to-very severe COPD. Total, central, and regional small airways deposition as a percentage of delivered dose of budesonide/glycopyrronium/formoterol fumarate dihydrate (BGF) 160/7.2/5 µg per actuation and fluticasone furoate/umeclidinium/vilanterol (FF/UM/VI) 100/62.5/25 µg were evaluated using in silico FRI based on in vitro aerodynamic particle size distributions of each device. Simulations were performed using multiple inhalation profiles of varying durations and flow rates representing patterns suited for a pressurized metered-dose inhaler or dry-powder inhaler (four for BGF, two for FF/UM/VI, with one common profile). For the common profile, deposition for BGF versus FF/UM/VI was compared post-hoc using paired t-tests. Results Across inhalation profiles, mean total lung deposition was consistently higher with BGF (47.0–54.1%) versus FF/UM/VI (20.8–22.7%) and for each treatment component, with greater deposition for BGF also seen in the central large airways. Mean regional small airways deposition was also greater across inhalation profiles with BGF (16.9–23.6%) versus FF/UM/VI (6.8–8.7%) and for each treatment component. For the common profile, total, central, and regional small airways deposition were significantly greater for BGF versus FF/UM/VI (nominal p < 0.001), overall and for treatment components; notably, regional small airways deposition of the ICS components was approximately five-fold greater with budesonide versus fluticasone furoate (16.1% vs. 3.3%). Conclusions BGF was associated with greater total, central, and small airways deposition for all components versus FF/UM/VI. Importantly, using an identical inhalation profile, there was an approximately five-fold difference in small airways deposition for the ICS components, with only a small percentage of the ICS from FF/UM/VI reaching the small airways. Further research is needed to understand if the enhanced delivery of BGF translates to clinical benefits. Graphical Abstract

The 82-year-old who plays cricket wearing an oxygen tank. This is a lovely story. But it reminds me how much weaker my dad was when diagnosed suddenly with the same terminal disease in late 2019. He was too weak to have portable oxygen. He spent the last 2.5 years of his life hooked up permanently to an oxygen machine at home. But it's lovely to see this gent happy. bbc.co.uk/news/uk-scotland-667 #Dundee #StAndrews #PulmonaryFibrosis #LungDisease #Respiratory #Terminal #Cricket #Scotland #Medicine #NHS

BBC NewsThe 82-year-old who plays cricket wearing an oxygen tankAlec Steele has a terminal illness but he is determined to carry on playing cricket.

So, any of my followers know any PWD who live in New Mexico who wouldn't mind chatting with a #Deafblind #spoony with #serviceDogs who is thinking about perhaps moving there? #ClimateChange is making it hard almost impossible for me to continue living here so I'm looking at leaving in a year or 2. I have #LungDisease and need to live where the winters don't get too cold but also I don't want to live where there are hurricanes because thats why I'm leaving #NewOrleans.