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John Vaccaro (johniac)SciTech Chronicles . . . .May 8th, 2025<a href="https://bit.ly/stc050825" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://bit.ly/stc050825</a><a href="https://mastodon.social/tags/SIK3" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SIK3</a> <a href="https://mastodon.social/tags/NSS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NSS</a> <a href="https://mastodon.social/tags/profile" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#profile</a> <a href="https://mastodon.social/tags/kinase" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#kinase</a> <a href="https://mastodon.social/tags/pathogens" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pathogens</a> <a href="https://mastodon.social/tags/intercontinental" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#intercontinental</a> <a href="https://mastodon.social/tags/balloons" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#balloons</a> #"35 kilometers" #"jurema preta" <a href="https://mastodon.social/tags/dimethyltryptamine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#dimethyltryptamine</a> #"no ban" #"Mimosa tenuiflora" <a href="https://mastodon.social/tags/TYK2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TYK2</a> <a href="https://mastodon.social/tags/psoriasis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#psoriasis</a> <a href="https://mastodon.social/tags/inhibitor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inhibitor</a> <a href="https://mastodon.social/tags/signaling" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#signaling</a> <a href="https://mastodon.social/tags/Friendship" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Friendship</a> #"Lamprotornis superbus" <a href="https://mastodon.social/tags/reciprocal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#reciprocal</a> <a href="https://mastodon.social/tags/DNA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#DNA</a>

Giuseppe MichieliCoadministration of <a href="https://mstdn.science/tags/ribavirin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ribavirin</a> and <a href="https://mstdn.science/tags/arenaviral" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#arenaviral</a> entry <a href="https://mstdn.science/tags/inhibitor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inhibitor</a> LHF-535 enhances antiviral benefit against authentic <a href="https://mstdn.science/tags/Lassa" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Lassa</a> virus, <a href="https://etidiohnew.blogspot.com/2025/04/coadministration-of-ribavirin-and.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://etidiohnew.blogspot.com/2025/04/coadministration-of-ribavirin-and.html</a>

Giuseppe MichieliA <a href="https://mstdn.science/tags/coronavirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#coronavirus</a> assembly <a href="https://mstdn.science/tags/inhibitor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inhibitor</a> that targets the viral <a href="https://mstdn.science/tags/membrane" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#membrane</a> protein, <a href="https://etidiohnew.blogspot.com/2025/03/a-coronavirus-assembly-inhibitor-that.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://etidiohnew.blogspot.com/2025/03/a-coronavirus-assembly-inhibitor-that.html</a>

Mauro MaverUnveiling the ethylene-inhibiting mechanism of the allelochemical Myrigalone A 🌱🧪👉 <a href="https://www.mauromaver.eu/posts/posts_omnia/focus_II/2/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.mauromaver.eu/posts/posts_omnia/focus_II/2/</a><a href="https://sciences.social/tags/Science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Science</a> <a href="https://sciences.social/tags/Research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Research</a> <a href="https://sciences.social/tags/academia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#academia</a> <a href="https://sciences.social/tags/PlantScience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PlantScience</a> <a href="https://sciences.social/tags/Plant" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Plant</a> <a href="https://sciences.social/tags/scientificwriting" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#scientificwriting</a> <a href="https://sciences.social/tags/editorial" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#editorial</a> <a href="https://sciences.social/tags/allelopathy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#allelopathy</a> <a href="https://sciences.social/tags/ethylene" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ethylene</a> <a href="https://sciences.social/tags/inhibitor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inhibitor</a>

Giuseppe Michieli<a href="https://mstdn.science/tags/Synergistic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Synergistic</a> activity of an <a href="https://mstdn.science/tags/RNA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#RNA</a> <a href="https://mstdn.science/tags/polymerase" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#polymerase</a> PA-PB1 interaction <a href="https://mstdn.science/tags/inhibitor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inhibitor</a> with <a href="https://mstdn.science/tags/oseltamivir" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#oseltamivir</a> vs <a href="https://mstdn.science/tags/human" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#human</a> & avian <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#influenza</a> viruses in <a href="https://mstdn.science/tags/cell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cell</a> culture & in ovo, Antiviral Res.: <a href="https://www.sciencedirect.com/science/article/abs/pii/S016635422400189X?via%3Dihub" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.sciencedirect.com/science/article/abs/pii/S016635422400189X?via%3Dihub</a> The PA-PB1 interaction inhibitor '54' acts synergistically with oseltamivir vs influenza A & B. '54' & oseltamivir combined at low doses inhibit viral progeny production & proteins expression in cell culture. 54 inhibits avian influenza replication both in cell culture & in embryonated chicken eggs.

Giuseppe Michieli<a href="https://mstdn.science/tags/Efficacy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Efficacy</a> of <a href="https://mstdn.science/tags/host" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#host</a> <a href="https://mstdn.science/tags/cell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cell</a> serine <a href="https://mstdn.science/tags/protease" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#protease</a> <a href="https://mstdn.science/tags/inhibitor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inhibitor</a> MM3122 against <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SARS</a>-CoV-2 for <a href="https://mstdn.science/tags/treatment" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#treatment</a> and <a href="https://mstdn.science/tags/prevention" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#prevention</a> of <a href="https://mstdn.science/tags/COVID19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#COVID19</a>, J Virol.: <a href="https://doi.org/10.1128/jvi.01903-23" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/10.1128/jvi.01903-23</a> Herein, we demonstrate that MM3122 potently inhibits viral replication in human lung epithelial cells and is also effective against the EG.5.1 variant of SARS-CoV-2.

Matt WillemsenPromising Findings – Scientists Successfully Revive Lost Brain Function Following Stroke <a href="https://scitechdaily.com/promising-findings-scientists-successfully-revive-lost-brain-function-following-stroke/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://scitechdaily.com/promising-findings-scientists-successfully-revive-lost-brain-function-following-stroke/</a> <a href="https://mastodon.social/tags/stroke" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#stroke</a> <a href="https://mastodon.social/tags/brain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#brain</a> <a href="https://mastodon.social/tags/mice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mice</a> <a href="https://mastodon.social/tags/ischemic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ischemic</a> <a href="https://mastodon.social/tags/mGluR5" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mGluR5</a> <a href="https://mastodon.social/tags/inhibitor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inhibitor</a> <a href="https://mastodon.social/tags/regained" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#regained</a> <a href="https://mastodon.social/tags/functions" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#functions</a>

Giuseppe Michieli<a href="https://mstdn.science/tags/Resistance" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Resistance</a> profiles for the investigational <a href="https://mstdn.science/tags/neuraminidase" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuraminidase</a> <a href="https://mstdn.science/tags/inhibitor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inhibitor</a> AV5080 in <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#influenza</a> a and B viruses <a href="https://pubmed.ncbi.nlm.nih.gov/37567255/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1LGAx__djGAJ9poBzWGqPtjEbBDtz4ipSRRPUplmgHEyyF_Ihj&fc=None&ff=20230812112307&v=2.17.9.post6+86293ac" rel="nofollow noopener noreferrer" target="_blank">https://pubmed.ncbi.nlm.nih.gov/37567255/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1LGAx__djGAJ9poBzWGqPtjEbBDtz4ipSRRPUplmgHEyyF_Ihj&fc=None&ff=20230812112307&v=2.17.9.post6+86293ac</a> <a href="https://mstdn.science/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#science</a> <a href="https://mstdn.science/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#research</a> <a href="https://mstdn.science/tags/antivirals" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#antivirals</a> <a href="https://mstdn.science/tags/H1N1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#H1N1</a> <a href="https://mstdn.science/tags/H3N2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#H3N2</a> <a href="https://mstdn.science/tags/H7N9" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#H7N9</a> <a href="https://mstdn.science/tags/H5N1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#H5N1</a>

Giuseppe Michieli''Investigational oral neuraminidase <a href="https://mstdn.science/tags/inhibitor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inhibitor</a> AV5080 was most effective at reducing virus enzyme activity.''

Giuseppe MichieliEffect of <a href="https://mstdn.science/tags/ACE" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ACE</a> <a href="https://mstdn.science/tags/Inhibitor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Inhibitor</a> and <a href="https://mstdn.science/tags/ARB" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ARB</a> Initiation on Organ Support–Free Days in <a href="https://mstdn.science/tags/Patients" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Patients</a> Hospitalized With <a href="https://mstdn.science/tags/COVID19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#COVID19</a> A Randomized Clinical Trial - JAMA: <a href="https://jamanetwork.com/journals/jama/fullarticle/2803515?guestAccessKey=4694d866-267a-4a5d-9bbb-54479425c945&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=etoc&utm_term=041123" rel="nofollow noopener noreferrer" target="_blank">https://jamanetwork.com/journals/jama/fullarticle/2803515?guestAccessKey=4694d866-267a-4a5d-9bbb-54479425c945&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=etoc&utm_term=041123</a>

Giuseppe MichieliTRPC6 <a href="https://mstdn.science/tags/inhibitor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inhibitor</a> (BI 764198) to reduce <a href="https://mstdn.science/tags/risk" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#risk</a> and severity of <a href="https://mstdn.science/tags/ARDS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ARDS</a> due to <a href="https://mstdn.science/tags/COVID19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#COVID19</a>: a phase II randomised controlled trial <a href="http://thorax.bmj.com/cgi/content/short/thorax-2022-219668v1?rss=1" rel="nofollow noopener noreferrer" target="_blank">http://thorax.bmj.com/cgi/content/short/thorax-2022-219668v1?rss=1</a>

Giuseppe Michieli<a href="https://mstdn.science/tags/Structure" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Structure</a>-based <a href="https://mstdn.science/tags/design" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#design</a> of a <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SARS</a>-CoV-2 <a href="https://mstdn.science/tags/Omicron" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Omicron</a>-specific <a href="https://mstdn.science/tags/inhibitor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inhibitor</a> <a href="https://www.pnas.org/doi/abs/10.1073/pnas.2300360120?af=R" rel="nofollow noopener noreferrer" target="_blank">https://www.pnas.org/doi/abs/10.1073/pnas.2300360120?af=R</a>

Chemistry ResearchDesign of CD73 <a href="https://mstdn.social/tags/inhibitor" class="mention hashtag" rel="tag">#inhibitor</a>|s Introduction of 3' alkynyl moiety led to drastically improved antitumor activity. E. B. Sjogren and colleagues from Calithera Biosciences described the synthesis of these orally available nucleoside analogues in the Journal of Medicinal <a href="https://mstdn.social/tags/Chemistry" class="mention hashtag" rel="tag">#Chemistry</a>.<a href="https://mstdn.social/tags/MedChem" class="mention hashtag" rel="tag">#MedChem</a> <a href="https://a.gup.pe/u/chemistry" class="u-url mention">@chemistry</a> <a href="https://mstdn.social/tags/Science" class="mention hashtag" rel="tag">#Science</a> <a href="https://mstdn.social/tags/Research" class="mention hashtag" rel="tag">#Research</a> <a href="https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01287" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01287</a>

Marco Radi<a href="https://qoto.org/tags/CUO246" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CUO246</a> from <a href="https://qoto.org/tags/Novartis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Novartis</a> is a promising DNA <a href="https://qoto.org/tags/gyrase" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#gyrase</a>/#topoisomerase IV dual <a href="https://qoto.org/tags/inhibitor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inhibitor</a> active against Gram-positive and Gram-negative <a href="https://qoto.org/tags/bacteria" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#bacteria</a>. <a href="https://journals.asm.org/doi/full/10.1128/aac.00921-22" rel="nofollow noopener noreferrer" target="_blank">https://journals.asm.org/doi/full/10.1128/aac.00921-22</a>

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