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#glycosylation

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#Hemagglutinin #glycosylation pattern-specific effects: implications for the #fitness of H9.4.2.5-branched #H9N2 avian #influenza viruses, Emerg Microbes Infect.: tandfonline.com/doi/full/10.10

Overall, our study provides a systematic insight into how changes in HA glycosylation patterns regulate the evolutionary fitness and epidemiological dominance drift of h9.4.2.5-branched H9N2 AIVs, which will be of great benefit for the glycosylation-dependent vaccine design.

Avian #influenza virus #NA #stalk length & #HA #glycosylation patterns reveal molecularly directed #reassortment promoting emergence of highly pathogenic #clade 2.3.4.4b A (#H5N1) viruses biorxiv.org/cgi/content/short/

These observations led us to establish and validate hypothesis that pairing of avian virus HA & NA subtypes is not stochastic but is rather molecularly programmed by HA glycosylation & NA stalk length, modulating fitness & emergence of novel avian influenza viruses.

"Our results suggest that, in a cellular context, Fab glycans inhibit IgG–hFcRn interaction and thus negatively affect the transplacental transfer of IgG. As Fab-glycosylated Abs are frequently associated with autoimmune and malignant disorders and may be potentially harmful, this might encompass a regulatory mechanism, limiting the half-life and transport of such Abs."

#immunology #glycosylation

journals.aai.org/jimmunol/arti

American Association of ImmunologistsIgG Fab Glycans Hinder FcRn-Mediated Placental TransportKey Points. The presence of Fab glycans hinders IgG interaction with hFcRn in a cell-based assay.Membrane context likely plays a key role, which conventional as