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#Gastroenterology

1 post1 participant0 posts today
Bibliolater 📚 📜 🖋

:iphonex: 🚽 **Smartphone use on the toilet and the risk of hemorrhoids**

"_The study suggests that prolonged engagement with smartphones while using the toilet may be associated with an increased prevalence of hemorrhoids._"

Ramprasad C, Wu C, Chang J, Rangan V, Iturrino J, et al. (2025) Smartphone use on the toilet and the risk of hemorrhoids. PLOS ONE 20(9): e0329983. doi.org/10.1371/journal.pone.0.

#OpenAccess #OA #Research #Science #Gastroenterology #Medicine #Health #Phones #Hemorrhoids #Toilet #Academia @science

doi.orgSmartphone use on the toilet and the risk of hemorrhoidsSmartphones are ubiquitous in daily life, with many people now using them while sitting on the toilet. Despite anecdotal evidence that length of time spent on the toilet is a risk factor for hemorrhoids, a multivariate analysis of smartphone use has not been performed. This study examines the correlation between smartphone use on the toilet and prevalence of hemorrhoids. A cross-sectional study was conducted among adult patients undergoing screening colonoscopy at Beth Israel Deaconess Medical Center. Participants completed survey questions regarding their smartphone habits while using the toilet, Rome IV questionnaires, and additional behaviors including straining, fiber intake and levels of physical activity. Presence of hemorrhoids were evaluated endoscopically and independently rated by two blinded endoscopists. Categorical variables were analyzed using chi-square tests and linear variables with regression analysis. A total of 125 adult participants completed the survey and 43% had hemorrhoids visualized on colonoscopy. Participants who used smartphones on the toilet were younger than non-users (mean ages 55.4 vs. 62.1, p = 0.001). Of all respondents, 66% used smartphones while on the toilet. Participants who used smartphones on the toilet spent significantly more time there than those who did not, with 37.3% of smartphone users spending more than five minutes per visit on the toilet, compared to 7.1% of non-smartphone users (p = 0.006). Furthermore, in a multivariate logistic regression, smartphone use on the toilet was associated with a 46% increased risk of hemorrhoids (p = 0.044) after adjusting for age, sex, BMI, exercise activity, straining and fiber intake. The most common activity performed while on the toilet was reading “news” (54.3%), followed by “social media” (44.4%). The study suggests that prolonged engagement with smartphones while using the toilet may be associated with an increased prevalence of hemorrhoids.
*
Rhyothemis

Is Extreme Running Linked to Colon Cancer?
youtu.be/m8Y0BQP1Pog

Katie Couric interviews Dr. Timothy Cannon, gastroenterologist and oncologist who conducted a study on elite endurance athletes and colorectal cancer. Dr Cannon presented his findings at the 2025 American Society of Clinical Oncology [ASCO] Annual Meeting in Chicago (link below). He discusses a possible link between runner's colitis and colorectal cancer.

Excerpts -

5:05
Cannon: it's going to take a huge effort to figure this out, but it is definitely real. I see them in our office every week, you know, patients under under 45, you under 40, often under 30 with colorectal cancer. I don't really remember seeing it that often, you know, 15 years ago.

34:23
Cannon: I think um uh the most common ones are bleeding in your stool. You know, that's a red flag that and again that back to the marathoners. So many of them were told it was normal if
you run. I would not accept that answer

Couric: Or they have hemorrhoids, right? People blow doctors blow people off and say, "Oh, don't worry."

Cannon: Right. Exactly. Yeah. That happens all the time. So - but bleeding in the stool is a sign.

34:55
Cannon: Abdominal pain is also a common symptom, but it's not there all the time. None of these are, in fact. So I think even having one of those things is enough of a reason to try to get checked out.

Link to study abstract:
meetings.asco.org/2025-asco-an

Link to press release on the study:
inovanewsroom.org/press-releas

YouTubeIs Extreme Running Linked to Colon Cancer?By Katie Couric
#gastroenterology#oncology#SportsMedicine
United States News Beep

Cholecystitis and cholangiocarcinoma: a two-sample Mendelian randomization study | BMC Gastroenterology

This study represents the first study to systematically evaluate the causal link between genetic susceptibility to cholecystitis and…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Genetics #Cholangiocarcinoma #Cholecystitis #Gastroenterology #Hepatology #InternalMedicine #Mendelianrandomizationanalysis #Science
newsbeep.com/us/111287/

ScienceOpen

🔬📄 'Efficacy and Feasibility of Tissue-Clearing Technique and Three-Dimensional Imaging in the Human Gastrointestinal Tissues Using Illuminate Cleared Organs to Identify Target Molecules' - a Karger: #Gastroenterology article on #ScienceOpen -

🔗 scienceopen.com/document?vid=0

ScienceOpenEfficacy and Feasibility of Tissue-Clearing Technique and Three-Dimensional Imaging in the Human Gastrointestinal Tissues Using Illuminate Cleared Organs to Identify Target Molecules<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" dir="auto" id="d7337466e239"> <b> <i>Introduction:</i> </b> Tissue-clearing technology has shown potential for comprehensive structural and functional analysis through three-dimensional (3D) imaging of biological tissue. However, its effectiveness in human specimens remains insufficiently explored. In this study, we validated the illuminate cleared organs to identify target molecules (LUCID) protocol for human gastrointestinal specimens and demonstrated its utility in enhancing tissue transparency and 3D imaging. <b> <i>Methods:</i> </b> The gastrointestinal mucosa specimens resected via endoscopic submucosal dissection including the esophagus, stomach, duodenum, and colon were fluorescently stained and optically cleared using LUCID. Cleared specimens were imaged in 3D form by confocal laser scanning microscope, and the observable depth at any five points was measured and compared to non-cleared specimens, respectively. After clearing and imaging, the specimens were restored to the formalin-fixed paraffin-embedded form again, and conventional two-dimensional pathological evaluation using hematoxylin-eosin, Ki67, p53, and E-cadherin staining was performed to compare them with their preclearing state. <b> <i>Results:</i> </b> The observable depth was significantly extended after clearing for specimens from each organ (esophagus 228.3 ± 14.9 µm vs. 1,036.7 ± 62.9 µm, <i>p</i> < 0.05; stomach 115.2 ± 5.5 µm vs. 428.7 ± 15.9 µm, <i>p</i> < 0.05; duodenum 256.2 ± 9.5 µm vs. 787.0 ± 18.6 µm, <i>p</i> < 0.05, colon 113.9 ± 5.4 µm vs. 436.6 ± 18.5 µm, <i>p</i> < 0.05). The pathological evaluation after clearing revealed a preserved fine structure and staining and showed no apparent deformation, degeneration, or tissue damage compared with before clearing. <b> <i>Conclusions:</i> </b> The effectiveness of tissue clearing using LUCID on human gastrointestinal specimens was demonstrated, and the LUCID protocol had minimal impact on specimen morphology and staining. LUCID is expected to be a method that enables comprehensive structural analysis of human gastrointestinal mucosa and lesions that may avoid missing microscopic findings that may occur in split-face pathological assessment. </p>
#TissueClearing#3DImaging#LUCIDProtocol
ScienceOpen

🔬📄 'In vivo Inhibition of Helicobacter pylori through Probiotics and Gastrointestinal Commensals: A Critical Review' - a Karger: #Gastroenterology article on #ScienceOpen -

🔗 scienceopen.com/document?vid=3

ScienceOpenIn vivo Inhibition of <i>Helicobacter pylori</i> through Probiotics and Gastrointestinal Commensals: A Critical Review<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" dir="auto" id="d7337970e228"> <b> <i>Background:</i> </b> <i>Helicobacter pylori</i> eradication is increasingly challenged, due to high antibiotic resistance rates in <i>H. pylori</i> and treatment failure. Consequently, new treatment regimens are needed. Probiotic and gastrointestinal bacteria exert anti- <i>H. pylori</i> activity in vivo, thus being potential add-on candidates for future eradication strategies. <b> <i>Summary:</i> </b> In this review, we summarised the currently available literature for in vivo inhibition of <i>H. pylori</i>. Included studies address anti- <i>H. pylori</i> effects in mouse and rat models caused by potentially beneficial bacteria. Research on literature was further extended to clinical eradication studies in humans. Several bacterial strains, mainly belonging to the <i>Lactobacillus</i> genus, inhibited <i>H. pylori</i> in vivo. In animal studies, probiotic bacteria and commensals reduced <i>H. pylori</i> colonisation and the inflammatory response. Certain probiotic species reduce <i>H. pylori</i> colonisation in humans. <b> <i>Key Messages:</i> </b> Probiotic and gastrointestinal commensals are beneficial in <i>H. pylori</i> eradication therapy. Their current role is the reduction of adverse events and <i>H. pylori</i> load. </p>
#HelicobacterPylori#Probiotics#Lactobacillus
ScienceOpen

'No Increased Risk of Venous Thromboembolism or Infectious Complications after Janus Kinase Inhibitor Exposure in Patients with Ulcerative Colitis Undergoing Surgery' - a Karger Publishers #Gastroenterology #Research article on #ScienceOpen:

🔗 scienceopen.com/document?vid=c

ScienceOpenNo Increased Risk of Venous Thromboembolism or Infectious Complications after Janus Kinase Inhibitor Exposure in Patients with Ulcerative Colitis Undergoing Surgery<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" dir="auto" id="d25860e234"> <b> <i>Introduction:</i> </b> Total colectomy for ulcerative colitis (UC) is associated with postoperative morbidity, including venous thromboembolic events (VTE). In light of recent concerns about increased major adverse events associated with Janus kinase (JAK) inhibitor exposure, we aimed to evaluate the postoperative VTE risk as well as other complications in UC patients undergoing colectomy. <b> <i>Methods:</i> </b> This single-center retrospective cohort study included all UC patients who underwent (procto)colectomy between 2013 and March 2022 and documented the 180-day postoperative non-infectious and infectious complications. <b> <i>Results:</i> </b> One hundred seventy-five UC patients (43.4% women, median age 41.0 years) underwent colectomy. Forty-nine patients (28.0%) were operated in an urgent setting. In the 12 weeks prior to surgery, 53 (30.3%) patients had received anti-TNF agents, 40 (22.9%) anti-adhesion therapy, 16 (9.1%) anti-IL12/23, and 34 (19.4%) JAK inhibitors. Preoperatively, 26 patients (14.9%) received moderate-to-high doses of systemic corticosteroids. All except 2 patients received prophylactic low-molecular-weight heparin postoperatively. During the 180-day postoperative period, 2 patients developed thrombosis, all incidental findings on abdominal CT scan. No VTE was seen in the patients who underwent colectomy while on JAK inhibitor. Three out of 34 JAK inhibitor-treated patients (8.8%) developed a postoperative infectious complication, while the overall incidence of infectious complications was 17.1%. <b> <i>Conclusion:</i> </b> Our findings suggest that the overall VTE risk in UC patients undergoing colectomy is low with adequate antithrombotic prophylaxis. JAK inhibitor use prior to surgery was not linked to increased short-term thromboembolic or infectious complications. However, the limited sample size warrants further study in larger cohorts. </p>
John Pohl

I had a wonderful time last week in Denver, Colorado catching up with other pediatric GI faculty (some I have known for over 2 decades) while teaching pediatric gastroenterologists-in-training from Mexico, the United States, and Canada. It was a great NASPGHAN teaching conference. Our pediatric gastroenterology fellows who will be future faculty across North America are inspiring and innovative! #medicine #gastroenterology

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