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Stephan HackerVery excited that Ed Tate will visit us for a <a href="https://mstdn.science/@LED3hub" class="u-url mention" rel="nofollow noopener" target="_blank">@LED3hub</a> Lecture on May 22nd and talk about cutting-edge <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener" target="_blank">#ChemBio</a> and <a href="https://mstdn.science/tags/chemoproteomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#chemoproteomics</a> research in the field of <a href="https://mstdn.science/tags/DrugDiscovery" class="mention hashtag" rel="nofollow noopener" target="_blank">#DrugDiscovery</a>. If you are interested, feel free to come by!<a href="https://mstdn.science/tags/Chemistry" class="mention hashtag" rel="nofollow noopener" target="_blank">#Chemistry</a>

Stephan HackerWhich flow rate is most suitable for MS-based <a href="https://mstdn.science/tags/proteomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#proteomics</a> and <a href="https://mstdn.science/tags/chemoproteomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#chemoproteomics</a> experiments?We have been thinking about this for a long time (nanoLC, capLC, µLC). According to a new <a href="https://biologists.social/@biorxivpreprint" class="u-url mention" rel="nofollow noopener" target="_blank">@biorxivpreprint</a> by the Küster lab, it seems like all options work very well with some specific advantages and diadvantages. <a href="https://www.biorxiv.org/content/10.1101/2025.04.10.648108v1" rel="nofollow noopener" translate="no" target="_blank">https://www.biorxiv.org/content/10.1101/2025.04.10.648108v1</a>

Stephan Hacker<a href="https://mstdn.science/tags/FocusOnCovalentDrugs" class="mention hashtag" rel="nofollow noopener" target="_blank">#FocusOnCovalentDrugs</a> was a great meeting with talks covering diverse aspects of targeted covalent inhibitor discovery ranging from warhead development and <a href="https://mstdn.science/tags/chemoproteomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#chemoproteomics</a> to very advanced PK/PD topics. Thank you so much to the organizers for inviting me and to everyone for the fruitful discussions.

Stephan HackerAmazing talk by Sebastian Essig at <a href="https://mstdn.science/tags/FocusOnCovalentDrugs" class="mention hashtag" rel="nofollow noopener" target="_blank">#FocusOnCovalentDrugs</a>. He talked about covalent drug discovery with a focus on characterizing novel warheads. Great insights into library design, reactivity profiling and <a href="https://mstdn.science/tags/chemoproteomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#chemoproteomics</a> for global analysis of selectivity.

Stephan HackerHe started by talking about the challenge of designing selective kinase inhibitors. He highlighted the importance of selectivity profiling with e.g. enzymatic assays, Kinobeads, nanoBRET or using <a href="https://mstdn.science/tags/chemoproteomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#chemoproteomics</a> such as in pioneering work by the Jack Taunton group (2/5) <a href="https://pubs.acs.org/doi/10.1021/jacs.6b08536" rel="nofollow noopener" translate="no" target="_blank">https://pubs.acs.org/doi/10.1021/jacs.6b08536</a>

Stephan Hacker<a href="https://mstdn.science/tags/FocusOnCovalentDrugs" class="mention hashtag" rel="nofollow noopener" target="_blank">#FocusOnCovalentDrugs</a> is off to a great start with an inspiring talk by Marcus Bantscheff. He talked about the various <a href="https://mstdn.science/tags/chemoproteomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#chemoproteomics</a> technologies that his group is applying to better understand the targets of small molecule drugs. Interesting insights into <a href="https://mstdn.science/tags/ABPP" class="mention hashtag" rel="nofollow noopener" target="_blank">#ABPP</a> and <a href="https://mstdn.science/tags/TPP" class="mention hashtag" rel="nofollow noopener" target="_blank">#TPP</a>. (1/2) <a href="https://mstdn.science/tags/Chemistry" class="mention hashtag" rel="nofollow noopener" target="_blank">#Chemistry</a> <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener" target="_blank">#ChemBio</a>

Stephan HackerFinally, he discussed the options to develop workflows that allow to perform lipid <a href="https://mstdn.science/tags/chemoproteomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#chemoproteomics</a> in a site-specific and lipid-specific fashion. Interesting insights into all the different challenges that come with identifying highly lipophilic, lipidated proteins and peptides. (5/5)

Stephan HackerImpressive talk by Georgia Andriopoulou from the group of Madeline Kavanagh of the <a href="https://mstdn.science/@LED3hub" class="u-url mention" rel="nofollow noopener" target="_blank">@LED3hub</a> at <a href="https://mstdn.science/tags/Lunteren" class="mention hashtag" rel="nofollow noopener" target="_blank">#Lunteren</a>. She talked about her research into developing new libraries of covalent compounds with tailored properties for <a href="https://mstdn.science/tags/chemoproteomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#chemoproteomics</a> identification of new therapeutic targets.

Cell Chemical BiologyProfiling nuclear <a href="https://mstdn.science/tags/cysteine" class="mention hashtag" rel="nofollow noopener" target="_blank">#cysteine</a> ligandability and effects on nuclear <a href="https://mstdn.science/tags/localization" class="mention hashtag" rel="nofollow noopener" target="_blank">#localization</a> using <a href="https://mstdn.science/tags/proximity" class="mention hashtag" rel="nofollow noopener" target="_blank">#proximity</a> labeling-coupled <a href="https://mstdn.science/tags/chemoproteomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#chemoproteomics</a> by Qianni Peng and Eranthie Weerapana at @BostonCollege @ChemistryBC <a href="https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00425-7?rss=yes&utm_source=dlvr.it&utm_medium=mastodon" rel="nofollow noopener" translate="no" target="_blank">https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00425-7?rss=yes&utm_source=dlvr.it&utm_medium=mastodon</a>

JIPBZhang et al. use <a href="https://mstdn.science/tags/chemoproteomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#chemoproteomics</a> to identify the epoxidase enzyme responsible for <a href="https://mstdn.science/tags/biosynthesis" class="mention hashtag" rel="nofollow noopener" target="_blank">#biosynthesis</a> of the <a href="https://mstdn.science/tags/anticancer" class="mention hashtag" rel="nofollow noopener" target="_blank">#anticancer</a> <a href="https://mstdn.science/tags/drug" class="mention hashtag" rel="nofollow noopener" target="_blank">#drug</a> <a href="https://mstdn.science/tags/camptothecin" class="mention hashtag" rel="nofollow noopener" target="_blank">#camptothecin</a> in Ophiorrhiza pumila. <a href="https://doi.org/10.1111/jipb.13594" rel="nofollow noopener" translate="no" target="_blank">https://doi.org/10.1111/jipb.13594</a> @wileyplantsci <a href="https://mstdn.science/tags/JIPB" class="mention hashtag" rel="nofollow noopener" target="_blank">#JIPB</a> <a href="https://mstdn.science/tags/PlantSci" class="mention hashtag" rel="nofollow noopener" target="_blank">#PlantSci</a> <a href="https://mstdn.science/tags/medicine" class="mention hashtag" rel="nofollow noopener" target="_blank">#medicine</a> <a href="https://mstdn.science/tags/PlantScience" class="mention hashtag" rel="nofollow noopener" target="_blank">#PlantScience</a> <a href="https://mstdn.science/tags/botany" class="mention hashtag" rel="nofollow noopener" target="_blank">#botany</a> <a href="https://mstdn.science/tags/cancer" class="mention hashtag" rel="nofollow noopener" target="_blank">#cancer</a> <a href="https://mstdn.science/tags/CancerResearch" class="mention hashtag" rel="nofollow noopener" target="_blank">#CancerResearch</a>

Stephan Hacker<a href="https://mstdn.social/@UCDProteomics" class="u-url mention" rel="nofollow noopener" target="_blank">@UCDProteomics</a> Very interesting. We recently started with SP3 in our lab and partly it gives amazing results compared to a urea in solution digest. Nevertheless, we also seem to get some inconsistency from prep to prep. So, there might actually be some trickiness to learning or teaching it. We will have to do some troubleshooting. Probably starting with binding and digest. <a href="https://mstdn.science/tags/Proteomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#Proteomics</a> <a href="https://mstdn.science/tags/Chemoproteomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#Chemoproteomics</a>

Stephan HackerAs I recently joined, I would like to introduce myself. I am an Assistant Professor at Leiden University, where my group works on covalent inhibitors and chemoproteomic technologies to discover new targets for antibiotics. Next to sharing our science, I am striving to share thoughts on the scientific literature that I read with a focus on <a href="https://mstdn.science/tags/ChemicalBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#ChemicalBiology</a>, <a href="https://mstdn.science/tags/Chemoproteomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#Chemoproteomics</a> and <a href="https://mstdn.science/tags/Antibiotics" class="mention hashtag" rel="nofollow noopener" target="_blank">#Antibiotics</a>. It would be great, if you follow me, if you are interested in these topics. <a href="https://www.universiteitleiden.nl/en/staffmembers/stephan-hacker#tab-1" rel="nofollow noopener" target="_blank">https://www.universiteitleiden.nl/en/staffmembers/stephan-hacker#tab-1</a>

Jeremy BaskinHi everyone! I'm @basktastic on Twitter but am trying out my real name here. My <a href="https://mstdn.science/tags/chembio" class="mention hashtag" rel="nofollow noopener" target="_blank">#chembio</a> <a href="https://mstdn.science/tags/cellbio" class="mention hashtag" rel="nofollow noopener" target="_blank">#cellbio</a> <a href="https://mstdn.science/tags/lipidtime" class="mention hashtag" rel="nofollow noopener" target="_blank">#lipidtime</a> lab at Cornell develops tools for imaging and editing the lipidome, drawing on <a href="https://mstdn.science/tags/bioorthogonal" class="mention hashtag" rel="nofollow noopener" target="_blank">#bioorthogonal</a> chemistry, <a href="https://mstdn.science/tags/clickchemistry" class="mention hashtag" rel="nofollow noopener" target="_blank">#clickchemistry</a>, <a href="https://mstdn.science/tags/chemoproteomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#chemoproteomics</a>, <a href="https://mstdn.science/tags/optogenetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#optogenetics</a>, <a href="https://mstdn.science/tags/directedevolution" class="mention hashtag" rel="nofollow noopener" target="_blank">#directedevolution</a>, and more. <a href="https://baskin.wicmb.cornell.edu" rel="nofollow noopener" target="_blank">https://baskin.wicmb.cornell.edu</a>

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