Multiple #myeloma often requires IRE1 to sustain malignant growth, but why? This study shows that IRE1 promotes #CellCycle progression via the transcription factor IRF4, paving the way for new therapeutic strategies @PLOSBiology https://plos.io/43TnG0L
ER-resident IRE1 plays a role in #cancer development via enzymatic activation of XPB1 TFs and regulated #RNAdecay. This study shows that some cancer cells also have an unexpected nonenzymatic dependency on IRE1 to promote #CellCycle progression & tumor growth @PLOSBiology https://plos.io/3EaNFX4
Current methods to study #CellCycle progression in #yeast ignore variations in cell size. The FLCCR reporter system can quantify the duration of cell cycle phase in single cells, allowing independent assessment of cell size & cell cycle progression #plosbiology https://plos.io/4j48NxJ
From post 5,
Amino acids that are enriched/depleted next to the phospho-site reflect which protein kinase enzymes did the phosphorylation.
Phospho-dawn sees acid-directed sites being phosphorylated (D and E enriched at ZT0),
but by evening it's #CellCycle kinases guided by Proline (P at ZT12-16). 
Apicomplexan #parasite division: @MGissot &co show that the #phosphatase TgPP1 in #Toxoplasma regulates the #CellCycle & amylopectin accumulation by dephosphorylating inner membrane complex & starch-binding domain proteins #PLOSBiology https://plos.io/3XwMYgj
How do cells respond to defects in nuclear reassembly after #mitosis? This study in #Drosophila shows that damaged cells are either removed by #apoptosis or activate a p53-dependent #CellCycle checkpoint to maintain tissue integrity #PLOSBiology https://plos.io/3AA4g4c
“In this preprint, the authors (Saykali et al.) turned into cinematographers, capturing the real time dynamics of CDKs using a very sensitive sensor.” 
Another lovely, entertaining preLight prepared by Mansi - check it out! 
#preLight 
https://prelights.biologists.com/highlights/lineage-specific-cdk-activity-dynamics-characterize-early-mammalian-development/
Quantifying DNA replication speeds in single cells by scEdU-seq #singlecell #cellcycle #newtech
Unraveling the Mechanisms: Regulation of DNA Replication in Bacterial Cells
#Bacteria, #CellCycle, #DNA, #DNAReplication, #DnaA, #OriC, #RegulatoryProteins, #Replication #Genetics, #MolecularBiology DNA replication is a fundamental process in all living organisms, ensuring the faithful transmission of genetic information from one generation to the next. In bacterial cells, where simplicity meets efficiency…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs…
Cell cycle genes are re-activated in some #neurons as our brains age. This study uses bioinformatics to characterize the prevalence, nature & fate of these #CellCycle re-entry neurons, within the healthy #aging & diseased human brain. #PLOSBiology https://plos.io/4dbHoXt
When you have “ATM” in your name your destiny is to either work for a bank or become a researcher specialising in #DNAdamage #science #CellCycle
New #ReviewedPreprint investigates the regulatory role of Mecp2 in #quiescence exit, providing “fundamental insights” into the mechanism controlling the #CellCycle.
Chromatin is less mobile during S-phase compared to G1 and G2 phases of the #CellCycle, new study finds.
#ReviewedPreprint with public reviews by @eLife-
Proliferating cells need to maintain a stable size distribution across the generations. This study shows that this is achieved by tightly controlling #CellSize variation throughout the #CellCycle, mainly via regulation of cell growth rate #PLOSBiology https://plos.io/4aMUWHS
How do #cellcycle oscillators generate exactly two #meiotic divisions for production of haploid #gametes?
Wolfgang Zachariae and colleagues show that #Spo13/#MEIKIN and #Cdc5/#Plk1 cooperate to prevent premature APC/C-#Ama1 activation after #meiosis I
https://www.embopress.org/doi/full/10.15252/embj.2023114288
#Phosphorylation control in #mitosis:
Julie Welburn and colleagues reveal the molecular basis for #cellcycle regulation of #Kif4A and #CENPE motor interaction with #PRC1, needed to organize antiparallel #microtubule bundles and to ensure central spindle integrity, #midbody assembly and #cytokinesis
cell 
cyclists & DNA replicationists take note 
super interesting thread by kristina jonas on twitter (X):
https://twitter.com/krijonas/status/1684903480069128192
bacterial cell cyclists take note
'The Nordström Question' by William D. Donachie. This will remain one of the most memorable papers I’ve ever read by the end of my career. — Suckjoon Jun @junlab_ucsd
(https://twitter.com/junlab_ucsd/status/1673262090734141440)
A #transcription-independent mechanism -#RBM10-mediated RNA alternative #splicing coupled to nonsense-mediated #mRNA decay- determines rapid periodic fluctuations of #BRCA1 expression throughout the #cellcycle
"In this study, we revisit and significantly extend the initiator-titration model, proposed thirty years ago, and explain how bacteria precisely and robustly control replication initiation based on the mechanism of protein copy-number sensing."
