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#ProteinPrediction

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MCDuncanLab<p>Nice study from <span class="h-card" translate="no"><a href="https://mstdn.science/@teresa_omeara" class="u-url mention">@<span>teresa_omeara</span></a></span> &amp; <span class="h-card" translate="no"><a href="https://mas.to/@maom" class="u-url mention">@<span>maom</span></a></span> in <span class="h-card" translate="no"><a href="https://biologists.social/@biorxivpreprint" class="u-url mention">@<span>biorxivpreprint</span></a></span> </p><p>They used protein prediction to explore the poorly annotated Candida auris genome, and then used protein design to replace endogenous proteins with de novo designed ones.</p><p><a href="https://www.biorxiv.org/content/10.1101/2025.05.14.654010v1" target="_blank" rel="nofollow noopener" translate="no"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">25.05.14.654010v1</span></a></p><p><a href="https://mstdn.social/tags/StructuralBiology" class="mention hashtag" rel="tag">#<span>StructuralBiology</span></a> <a href="https://mstdn.social/tags/AlphaFold2" class="mention hashtag" rel="tag">#<span>AlphaFold2</span></a> <a href="https://mstdn.social/tags/proteinPrediction" class="mention hashtag" rel="tag">#<span>proteinPrediction</span></a></p>
MCDuncanLab<p><span class="h-card" translate="no"><a href="https://genomic.social/@cmdcolin" class="u-url mention">@<span>cmdcolin</span></a></span> </p><p>I use Alphafold (actually colabfold) and am happy to answer questions, but I&#39;m just a user. There are people with more expertise than me here.</p><p>Hashtags might find the right people</p><p><a href="https://mstdn.social/tags/StructurePrediction" class="mention hashtag" rel="tag">#<span>StructurePrediction</span></a> <a href="https://mstdn.social/tags/alphafold" class="mention hashtag" rel="tag">#<span>alphafold</span></a> <a href="https://mstdn.social/tags/alphafold2" class="mention hashtag" rel="tag">#<span>alphafold2</span></a> <a href="https://mstdn.social/tags/colabfold" class="mention hashtag" rel="tag">#<span>colabfold</span></a> <a href="https://mstdn.social/tags/ProteinStructure" class="mention hashtag" rel="tag">#<span>ProteinStructure</span></a> <a href="https://mstdn.social/tags/StructuralBiology" class="mention hashtag" rel="tag">#<span>StructuralBiology</span></a> <a href="https://mstdn.social/tags/ProteinPrediction" class="mention hashtag" rel="tag">#<span>ProteinPrediction</span></a> <a href="https://mstdn.social/tags/protein" class="mention hashtag" rel="tag">#<span>protein</span></a> <a href="https://mstdn.social/tags/bioinformatics" class="mention hashtag" rel="tag">#<span>bioinformatics</span></a></p>
MCDuncanLab<p>Note in point.</p><p>What does it mean when only your rank 1 model suggests an interaction between two proteins with alphafold multimer? Is this garbage?</p><p><a href="https://mstdn.social/tags/AlphaFoldMultimer" class="mention hashtag" rel="tag">#<span>AlphaFoldMultimer</span></a><br /><a href="https://mstdn.social/tags/AlphaFold" class="mention hashtag" rel="tag">#<span>AlphaFold</span></a> <br /><a href="https://mstdn.social/tags/AlphaFold2" class="mention hashtag" rel="tag">#<span>AlphaFold2</span></a> <br /><a href="https://mstdn.social/tags/ProteinPrediction" class="mention hashtag" rel="tag">#<span>ProteinPrediction</span></a> <br /><a href="https://mstdn.social/tags/StructurePredictions" class="mention hashtag" rel="tag">#<span>StructurePredictions</span></a> <br /><a href="https://mstdn.social/tags/ProteinPredictionHelp" class="mention hashtag" rel="tag">#<span>ProteinPredictionHelp</span></a></p>
MCDuncanLab<p>Clearly, there is still much to learn about this corner of the dark genome defined by HEATR5 proteins and their co-factors.</p><p><a href="https://mstdn.social/tags/Biorxiv" class="mention hashtag" rel="tag">#<span>Biorxiv</span></a> <a href="https://mstdn.social/tags/Preprint" class="mention hashtag" rel="tag">#<span>Preprint</span></a> <a href="https://mstdn.social/tags/MembraneTraffic" class="mention hashtag" rel="tag">#<span>MembraneTraffic</span></a> <a href="https://mstdn.social/tags/DarkGenome" class="mention hashtag" rel="tag">#<span>DarkGenome</span></a> <a href="https://mstdn.social/tags/DarkProteome" class="mention hashtag" rel="tag">#<span>DarkProteome</span></a> <a href="https://mstdn.social/tags/RareDisease" class="mention hashtag" rel="tag">#<span>RareDisease</span></a> <a href="https://mstdn.social/tags/AlphaFold" class="mention hashtag" rel="tag">#<span>AlphaFold</span></a> <a href="https://mstdn.social/tags/AlphaFold2" class="mention hashtag" rel="tag">#<span>AlphaFold2</span></a> <a href="https://mstdn.social/tags/ProteinPrediction" class="mention hashtag" rel="tag">#<span>ProteinPrediction</span></a> <a href="https://mstdn.social/tags/Golgi" class="mention hashtag" rel="tag">#<span>Golgi</span></a> <a href="https://mstdn.social/tags/Clathrin" class="mention hashtag" rel="tag">#<span>Clathrin</span></a> <a href="https://mstdn.social/tags/CellBiology" class="mention hashtag" rel="tag">#<span>CellBiology</span></a> <a href="https://mstdn.social/tags/biochemistry" class="mention hashtag" rel="tag">#<span>biochemistry</span></a> <a href="https://mstdn.social/tags/Bioscience" class="mention hashtag" rel="tag">#<span>Bioscience</span></a></p>