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#PrimaryCilia

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PLOS Biology<p>Spatiotemporal analysis of &gt;10 million <a href="https://fediscience.org/tags/PrimaryCilia" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PrimaryCilia</span></a> in 22 mouse <a href="https://fediscience.org/tags/brain" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>brain</span></a> regions shows that <a href="https://fediscience.org/tags/cilia" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cilia</span></a> have region-specific length &amp; orientation patterns. <a href="https://fediscience.org/tags/Circadian" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Circadian</span></a> rhythms of cilia length suggest a role for cilia in the brain’s response to environmental changes <span class="h-card" translate="no"><a href="https://fediscience.org/@PLOSBiology" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>PLOSBiology</span></a></span> <a href="https://plos.io/4lWnfbQ" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">plos.io/4lWnfbQ</span><span class="invisible"></span></a></p>
PLOS Biology<p>How is <a href="https://fediscience.org/tags/melanin" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>melanin</span></a> production regulated? Study shows that on UV exposure <a href="https://fediscience.org/tags/MC1R" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MC1R</span></a> enters <a href="https://fediscience.org/tags/PrimaryCilia" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PrimaryCilia</span></a>, interacts with <a href="https://fediscience.org/tags/BBSome" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>BBSome</span></a> &amp; triggers signaling that stimulates <a href="https://fediscience.org/tags/melanogenesis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>melanogenesis</span></a>. The <a href="https://fediscience.org/tags/redhead" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>redhead</span></a> MC1R mutation affects BBSome binding, reducing melanin <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PLOSBiology</span></a> <a href="https://plos.io/4eZYebx" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">plos.io/4eZYebx</span><span class="invisible"></span></a></p>
PLOS Biology<p><a href="https://fediscience.org/tags/Hedgehog" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Hedgehog</span></a> (Hh) signaling: @Myers_lab shows that GPCR kinase 2 (GRK2) activates SMO in <a href="https://fediscience.org/tags/PrimaryCilia" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PrimaryCilia</span></a>, allowing its binding to PKA-C and Hh pathway activation in various cellular &amp; in vivo models <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PLOSBiology</span></a> <a href="https://plos.io/3AGYGgk" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">plos.io/3AGYGgk</span><span class="invisible"></span></a></p>
PLOS Biology<p>Ciliated <a href="https://fediscience.org/tags/photoreceptor" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>photoreceptor</span></a> cells have been well studied re <a href="https://fediscience.org/tags/RetinalDegeneration" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>RetinalDegeneration</span></a>, but what about <a href="https://fediscience.org/tags/PrimaryCilia" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PrimaryCilia</span></a> in other ocular cell types? Study shows that <a href="https://fediscience.org/tags/PrimaryCilium" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PrimaryCilium</span></a> in RPE is essential for development &amp; function; loss results in degeneration <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PLOSBiology</span></a> <a href="https://plos.io/3t2PwaG" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="">plos.io/3t2PwaG</span><span class="invisible"></span></a></p>
Jing Hughes<p><a href="https://mstdn.social/tags/Introduction" class="mention hashtag" rel="tag">#<span>Introduction</span></a> to <a href="https://mstdn.social/tags/ScienceMastodon" class="mention hashtag" rel="tag">#<span>ScienceMastodon</span></a><br />
I am a <a href="https://mstdn.social/tags/Cilia" class="mention hashtag" rel="tag">#<span>Cilia</span></a> <a href="https://mstdn.social/tags/Islet" class="mention hashtag" rel="tag">#<span>Islet</span></a> <a href="https://mstdn.social/tags/Biologist" class="mention hashtag" rel="tag">#<span>Biologist</span></a> and endocrinologist at WashU in St Louis.
<a href="https://mstdn.social/tags/PrimaryCilia" class="mention hashtag" rel="tag">#<span>PrimaryCilia</span></a> because it is the center of the cell and my world. <br />Unafraid to challenge convention and do difficult experiments (because we don’t know better). <br />Also <a href="https://mstdn.social/tags/Microscopy" class="mention hashtag" rel="tag">#<span>Microscopy</span></a> because seeing is believing. 

<a href="https://mstdn.social/tags/Cilia" class="mention hashtag" rel="tag">#<span>Cilia</span></a> <a href="https://mstdn.social/tags/cell" class="mention hashtag" rel="tag">#<span>cell</span></a> <a href="https://mstdn.social/tags/center" class="mention hashtag" rel="tag">#<span>center</span></a> <a href="https://mstdn.social/tags/cytoskeleton" class="mention hashtag" rel="tag">#<span>cytoskeleton</span></a> <a href="https://mstdn.social/tags/betacell" class="mention hashtag" rel="tag">#<span>betacell</span></a> <a href="https://mstdn.social/tags/signaling" class="mention hashtag" rel="tag">#<span>signaling</span></a> <a href="https://mstdn.social/tags/diabetes" class="mention hashtag" rel="tag">#<span>diabetes</span></a> </p><p>Image credit <a href="https://mstdn.social/tags/WUCCI" class="mention hashtag" rel="tag">#<span>WUCCI</span></a> and Alex Polino</p>
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