#RobSelects paper of the week #OrgLett: Addition of an activated C-H bond across vinyl azaarenes catalyzed by a Grubbs catalyst in favor of alkene cross-metathesis. #catalysis https://doi.org/10.1021/acs.orglett.3c03456

I am happy to share my recent publication in #OrgLett

We synthesized carbobicyclic nucleoside analogues which appear to be potent #antivirals against #RSV Despite their novel bicyclic structure, they adopt a ribose-like structure. This may be a new template for novel nucleoside analogues.

https://pubs.acs.org/doi/10.1021/acs.orglett.3c03590

Next step: Explore the mechanism of action.

My favourite reaction: aldol reaction. So it's no wonder that I present this publication: Total Synthesis of (+)-Coriamyrtin by Keiji Tanino and co-workers at #Hokkaido University (#Japan) using an intramolecular aldol reaction. Published in #OrgLett

#chemistry @chemistry
https://pubs.acs.org/doi/10.1021/acs.orglett.3c00249

Carbasugar #nucleoside analogues often lack biological activity, which is attributed to an unfavorable conformation. Locked nucleoside analogues, however, can mantain the ribose-like conformation. Another synthetic access is published in #OrgLett by Lak Shin Joeng and colleagues from Seoul National University (S. #Korea)

They were able to report the synthesis of the conformationally locked cytidine nucleoside analogue in 19 steps.

#chemistry #MedChem @chemistry
https://pubs.acs.org/doi/10.1021/acs.orglett.2c03853