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#glp1

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DrBob, Neurologist, 🧠Mechanic

GLP-1s Are Crazy Effective — Just Not Cost-Effective

I’ll make the argument that the most effective drugs in the past decade are the GLP-1 receptor agonists, drugs like semaglutide and tirzepatide. At least in terms of weight loss, they are truly unparalleled. They are clearly effective. But are they worth it? Are they cost-effective? That is a much harder question, and, as you’ll see in a minute, despite their amazing effects, the answer — for now, at least — is no.

#mounjaro #ozempic #zepbound #wegovy #glp1
medscape.com/viewarticle/glp-1

Medscape · GLP-1s Are Crazy Effective — Just Not Cost-EffectiveBy F. Perry Wilson, MD, MSCE
Public
Yonhap Infomax News

Novo Nordisk's ADR rises 1.04% to $80.98 following UBS's positive assessment and buy recommendation, despite overall market decline, as competition in obesity treatment market intensifies.
#YonhapInfomax #NovoNordisk #ADR #UBS #ObesityTreatment #GLP1 #Economics #FinancialMarkets #Banking #Securities #Bonds #StockMarket
en.infomaxai.com/news/articleV

Yonhap Infomax · Novo Nordisk ADR Rises on Positive UBS Assessment
More from Yonhap Infomax News
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Howard Smith MD, AM

Diabetes Under Better Control: Diabetes-related deaths dropped by 32% from 2000 to 2019. #diabetes #mortality #insulins #glp1 #latino #black #nativeamericans #alaskannative #asian #white
instagram.com/reel/DHWqGMHsxHy

InstagramHoward G. Smith MD, AM on Instagram: "Diabetes Under Better Control Diabetes-related deaths dropped by 32% from 2000 to 2019. That is a decline from 28.1 deaths per 100,000 people to 19.1 This progress in diabetic management occurred in all racial and ethnic groups. Epidemiologists from Seattle’s University of Washington report these heartening statistics after their review of data from US government databases. The declines were most significant for non-white and non-Asian Americans. Latino Americans had a 50% mortality decline, Native American and Alaskan Native peoples had a drop of 43.9%, and Black Americans had a drop of 43%. Asian Americans had 30% decline. White Americans had a 28% drop. These improvements occurred due to better therapy with improved insulins, GLP-1 medications, and statins all leading to better blood sugar management. The most significant improvements occurred between 2005 and 2013, but the progress rates have slowed more recently. Though every group saw improvements, we have much further to go. Native American and Black communities still have the highest diabetes mortality rates, especially in the Mississippi Delta, Texas, and parts of the Midwest. The data suggests that the key to equalizing this progress is expanding access to affordable care and improving dietary choices. . https://diabetesjournals.org/care/article/doi/10.2337/dc24-2259/157755/The-Burden-of-Diabetes-Mortality-by-County-Race https://www.healio.com/news/endocrinology/20250310/diabetes-mortality-rates-declined-in-us-from-2000-to-2019 #diabetes #mortality #insulins #glp1 #latino #black #nativeamericans #alaskannative #asian #white"0 likes, 0 comments - drhowardsmithreports on March 18, 2025: "Diabetes Under Better Control Diabetes-related deaths dropped by 32% from 2000 to 2019. That is a decline from 28.1 deaths per 100,000 people to 19.1 This progress in diabetic management occurred in all racial and ethnic groups. Epidemiologists from Seattle’s University of Washington report these heartening statistics after their review of data from US government databases. The declines were most significant for non-white and non-Asian Americans. Latino Americans had a 50% mortality decline, Native American and Alaskan Native peoples had a drop of 43.9%, and Black Americans had a drop of 43%. Asian Americans had 30% decline. White Americans had a 28% drop. These improvements occurred due to better therapy with improved insulins, GLP-1 medications, and statins all leading to better blood sugar management. The most significant improvements occurred between 2005 and 2013, but the progress rates have slowed more recently. Though every group saw improvements, we have much further to go. Native American and Black communities still have the highest diabetes mortality rates, especially in the Mississippi Delta, Texas, and parts of the Midwest. The data suggests that the key to equalizing this progress is expanding access to affordable care and improving dietary choices. . https://diabetesjournals.org/care/article/doi/10.2337/dc24-2259/157755/The-Burden-of-Diabetes-Mortality-by-County-Race https://www.healio.com/news/endocrinology/20250310/diabetes-mortality-rates-declined-in-us-from-2000-to-2019 #diabetes #mortality #insulins #glp1 #latino #black #nativeamericans #alaskannative #asian #white".
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BedastGPT

To be clear: Ozempic is a diabetes drug while Wegovy is the weight loss counterpart. This “new" molecule does NOT address glucose management by improving sensitivity to insulin nor improving insulin response to the consumption of carbs. This new molecule will also NOT have a protective nor regenerative effect on pancreatic beta cell islets as GLP-1 does.

This, strictly, appears to target satiety for weight loss.

The only relation to semaglutide is that it's a peptide and it promotes weight loss. It has no other similarites with GLP-1. The comparison only exists to indicate efficacy of intended effect.

#Diabetes #Ozempic #GLP1
twit.social/@twitnews/11413868

TWiT.socialTWiT News Feed (@twitnews@twit.social)Naturally occurring molecule rivals Ozempic in weight loss, sidesteps side effects - https://medicalxpress.com/news/2025-03-naturally-molecule-rivals-ozempic-weight.html A naturally occurring molecule identified by Stanford Medicine researchers appears similar to semaglutide—also known as Ozempic—in suppressing appetite and reducing body weight. Notably, testing in ... #im
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Brittany Trang

Some patients in trials for the newest weight-loss drugs are losing ~too much~ weight, eating peanut butter and skipping doses to avoid losing more.

But that conflicts with the industry's hunger for ever-larger weight loss percentages. How are those two interests getting reconciled?

statnews.com/2025/02/20/too-mu

STAT · How much weight loss is too much? Pharma is pushing the limit with new obesity drugsHow much weight loss is too much? Pharma is pushing the limit with new obesity drugs.
#GLP1#obesity#weightloss
Public
Howard Smith MD, AM

Dr. Howard Smith LIVE - 030325
==========================
HEALTH NEWS
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Vidcast: instagram.com/p/DGwL5PuN_sN/

InstagramHoward G. Smith MD, AM on Instagram: "Dr. Howard Smith LIVE - 030325 ========================== HEALTH NEWS ========================== • From the drug abuse department: the latest hot recreational drug is nitrous oxide. • Indoor Cats Catch Bird Flu from Owners • Artificial Sweetener Raises Heart Disease Risk • The Risks of Adaptogenic Mocktails • A blood test predicts risk of preterm birth. • Scientists Find Unique Method For Quantifying What You Eat • Diet Drugs Improve Your Thinking • Light-Triggered ‘Smart Bomb’ Kills Breast Cancer #drugabuse #nitrousoxide #cats #birdflu #aspartame #heartattack #insulin #mocktails #adaptogens #pregnancy #prematurity #dieting #fooddiary #obesity #glp1 #depression #dementia #cancer #chemophototherapy"0 likes, 0 comments - drhowardsmithreports on March 3, 2025: "Dr. Howard Smith LIVE - 030325 ========================== HEALTH NEWS ========================== • From the drug abuse department: the latest hot recreational drug is nitrous oxide. • Indoor Cats Catch Bird Flu from Owners • Artificial Sweetener Raises Heart Disease Risk • The Risks of Adaptogenic Mocktails • A blood test predicts risk of preterm birth. • Scientists Find Unique Method For Quantifying What You Eat • Diet Drugs Improve Your Thinking • Light-Triggered ‘Smart Bomb’ Kills Breast Cancer #drugabuse #nitrousoxide #cats #birdflu #aspartame #heartattack #insulin #mocktails #adaptogens #pregnancy #prematurity #dieting #fooddiary #obesity #glp1 #depression #dementia #cancer #chemophototherapy".
#drugabuse#nitrousoxide#cats
Public
DrBob, Neurologist, 🧠Mechanic

Forget Psychedelics 😵‍💫

Everyone’s Microdosing Ozempic Now 🤔

“Shamoon has joined the wave of people who are taking limited amounts not of psychedelics — to which the microdosing trend usually applies — but of the diabetes drug #Ozempic (#semaglutide), and other #GLP1 receptor agonists like #Mounjaro

They are doing it not primarily for weight loss — the effect that has made Ozempic a Hollywood staple and a reliable awards-show punchline — but for the surprising and widely touted side benefits, particularly its anti-inflammatory properties”

hollywoodreporter.com/lifestyl

Text Shot: Dr. Caroline Messer, a top Manhattan endocrinologist, reported that many of the people asking her about microdosing have come in because they are genetically predisposed to Alzheimer’s. “The key is not decreased blood sugar,” she says, “but decreased inflammation. In patients without diabetes, it doesn’t lower blood sugar but still has an anti-inflammatory effect.” And, it makes sense, she notes, because “Alzheimer’s is sometimes referred to as Type 3 diabetes. The brain in someone with Alzheimer’s exhibits insulin resistance, similar to what is seen in Type 2 diabetes.” Microdosing can have a lasting effect in achieving a mental edge, says Dr. Anetta Reszko, a Park Avenue dermatologist. “Unlike traditional dosing, which primarily targets appetite suppression and glucose regulation, microdosing semaglutide may provide a more gradual, sustained effect on the brain, immune system and overall cellular health,” she notes. “By modulating these pathways, it may help reduce…
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Nonya Bidniss :CIAverified:

Eye doctors at the University of Utah Health and elsewhere published the research, which describes several cases of vision complications possibly tied to these obesity and diabetes drugs. The medications were linked to three different eye conditions, all of which can lead to blindness. But as the doctors caution, the cases alone do not prove that GLP-1 drugs can cause these issues, and more research is needed to understand exactly what’s going on. #health #GLP1 gizmodo.com/eye-doctors-are-fi

Gizmodo · Eye Doctors Are Finding New Links Between Ozempic and Vision ProblemsA new case series links GLP-1 use to three different eye conditions, all of which can lead to blindness.
Continued thread
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Carolyn Barber, MD

weeks.

“We need more data to understand whether the benefits are sustained over long periods of time, & we don’t know whether these meds carry serious long-term risks after five or 10 years of use,” says @zalaly

And at an unsavory cost of $1-1.3K/month, we need to know. More here @Fortune
🎁 link: shorturl.at/XBEbn
#ozempicmedication #glp1 #press #weightloss

Fortune · Largest-ever Ozempic and GLP-1 drug study finds they lower risk of 42 health conditions, including heart attacks and Alzheimer’s diseaseBy Carolyn Barber
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