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#EndothelialCell

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Francoise Helmbacher<p>Big Congrats 🎉 to Rui Li &amp; collaborators from the lab of Stefan Offermanns at @mpi_hlr<br /> for this great <a href="https://mstdn.social/tags/NatureComms" class="mention hashtag" rel="tag">#<span>NatureComms</span></a> paper showing that FAT1 controls YAP/TAZ degradation via the E3 ligase MIB2 during <a href="https://mstdn.social/tags/angiogenesis" class="mention hashtag" rel="tag">#<span>angiogenesis</span></a>. </p><p>Happy of my small contribution!<br /><a href="https://doi.org/10.1038/s41467-023-37671-x" target="_blank" rel="nofollow noopener" translate="no"><span class="invisible">https://</span><span class="ellipsis">doi.org/10.1038/s41467-023-376</span><span class="invisible">71-x</span></a></p><p><a href="https://mstdn.social/tags/FAT1" class="mention hashtag" rel="tag">#<span>FAT1</span></a> <a href="https://mstdn.social/tags/YAP" class="mention hashtag" rel="tag">#<span>YAP</span></a> <a href="https://mstdn.social/tags/TAZ" class="mention hashtag" rel="tag">#<span>TAZ</span></a> <a href="https://mstdn.social/tags/angiogenesis" class="mention hashtag" rel="tag">#<span>angiogenesis</span></a> <a href="https://mstdn.social/tags/EndothelialCell" class="mention hashtag" rel="tag">#<span>EndothelialCell</span></a></p>
Hao Yin<p>IL-11 as a therapeutic target for lung <a href="https://qoto.org/tags/Fibrosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Fibrosis</span></a> <a href="https://qoto.org/tags/Emphysema" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Emphysema</span></a> in <a href="https://qoto.org/tags/MarfanSyndrome" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MarfanSyndrome</span></a></p><p>In Marfan🐭🫁, IL11-GFP reporter is active in <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a> <a href="https://qoto.org/tags/SmoothMuscleCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SmoothMuscleCell</span></a> Fibroblast but not alveolar epithelia</p><p>Dr. Stuart A Cook &amp; Wei Wen Lim lab ATVB 2023 <br><a href="https://www.ahajournals.org/doi/10.1161/ATVBAHA.122.318802" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">ahajournals.org/doi/10.1161/AT</span><span class="invisible">VBAHA.122.318802</span></a></p><p>Also don't miss the story on IL-11 as mediator of Mafan <a href="https://qoto.org/tags/Aortopathy" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Aortopathy</span></a> from Circ Res 2022</p><p><a href="https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.320381" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">ahajournals.org/doi/10.1161/CI</span><span class="invisible">RCRESAHA.121.320381</span></a></p>
Hao Yin<p>Human Meniscus single-cell RNAseq atlas<br>4 normal+4 <a href="https://qoto.org/tags/OsteoArthritis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>OsteoArthritis</span></a></p><p>5 <a href="https://qoto.org/tags/Chondroncyte" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Chondroncyte</span></a> subtypes<br>Emerging proliferative chondrocyte in degenerated tissue </p><p>OA-related <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a>/#MuralCell-Chondrocyte crosstalks🤓</p><p>Dr. W Fu &amp; X Zhang labs <span class="h-card"><a href="https://fediscience.org/@eLife" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>eLife</span></a></span> 2023<br><a href="https://elifesciences.org/articles/79585" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">elifesciences.org/articles/795</span><span class="invisible">85</span></a></p>
Hao Yin<p>Amh+ <a href="https://qoto.org/tags/SertoliCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SertoliCell</span></a> is a major (80%) cellular source of <a href="https://qoto.org/tags/StemCellFactor" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>StemCellFactor</span></a> in🐭Testis</p><p>Sertoli, Not <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a> SCF-&gt;<br><a href="https://qoto.org/tags/Spermatogonia" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Spermatogonia</span></a> maintenance+differentiation</p><p>Cell-specific SCF Glycosylation? Proximity?🧐</p><p>Dr Hongfang Shao, Bo Zhou lab <span class="h-card"><a href="https://mstdn.science/@Dev_journal" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>Dev_journal</span></a></span> 2023<br><a href="https://journals.biologists.com/dev/article/doi/10.1242/dev.200706/293491/Sertoli-cells-are-the-unique-source-of-stem-cell" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">journals.biologists.com/dev/ar</span><span class="invisible">ticle/doi/10.1242/dev.200706/293491/Sertoli-cells-are-the-unique-source-of-stem-cell</span></a></p>
Hao Yin<p>AP-1 transcription factors ATF3/FOSL1/FOSL2/c-JUN reshape Chromatin Accessibility landscape during <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a> <a href="https://qoto.org/tags/Senescence" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Senescence</span></a></p><p>HUVEC PD 8vs24vs36<br>1038 &amp; 964 increased &amp; decreased accessibility regions<br>&gt;94% &gt;2 kb from TSS</p><p>Dr. Wei Tao lab Aging Cell 2021<br><a href="https://onlinelibrary.wiley.com/doi/10.1111/acel.13315" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">onlinelibrary.wiley.com/doi/10</span><span class="invisible">.1111/acel.13315</span></a></p><p>AP-1 TFs also play pioneering roles in fibroblast <a href="https://qoto.org/tags/Senescence" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Senescence</span></a> 🤠</p><p>AP-1 imprints a reversible transcriptional programme of senescent cells</p><p>Dr. Oliver Bischof lab Nature Cell Bio 2020<br><a href="https://www.nature.com/articles/s41556-020-0529-5" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41556-020</span><span class="invisible">-0529-5</span></a></p>
Hao Yin<p><a href="https://qoto.org/tags/ArterioVenousFistula" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ArterioVenousFistula</span></a> <a href="https://qoto.org/tags/EndMT" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndMT</span></a></p><p>Low <a href="https://qoto.org/tags/OscillatoryShearStress" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>OscillatoryShearStress</span></a>-&gt;<br>⏫Osteopontin-CD44 in <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a>-&gt;<br>⏫EndMT-&gt;<br>⏫24% of neointimal cells at rat aortocaval junction</p><p>A cascade independent of <a href="https://qoto.org/tags/HyaluronicAcid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>HyaluronicAcid</span></a>🤓</p><p>Dr. Yung-Hsin Yeh lab Kidney Int 2023<br><a href="https://www.kidney-international.org/article/S0085-2538(23)00011-X/fulltext" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">kidney-international.org/artic</span><span class="invisible">le/S0085-2538(23)00011-X/fulltext</span></a></p>
Hao Yin<p>Single-nuclei Transcriptomics human Lung<br><a href="https://qoto.org/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>COVID19</span></a> x7<br>IPF x6<br>Ctrl x12</p><p>COVID🫁<br>⏫Systemic venous+capillary <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a><br>⏬general capillary EC<br>⏬Epi-Endo Notch, EC-stromal PDGF<br>⏫Stromal-EC PlxnA-Sema3A</p><p>Dr. Peter Carmeliet lab <a href="https://qoto.org/tags/CardiovascRes" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CardiovascRes</span></a> 2022<br><a href="https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvac139/6673943" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">academic.oup.com/cardiovascres</span><span class="invisible">/advance-article/doi/10.1093/cvr/cvac139/6673943</span></a></p>
Hao Yin<p>Blood Vessel Organoids for Development &amp; Disease</p><p>Self-organizing capillary blood vessel <a href="https://qoto.org/tags/Organoid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Organoid</span></a> <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a>+<a href="https://qoto.org/tags/Pericyte" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Pericyte</span></a> (+Astrocyte for <a href="https://qoto.org/tags/BBB" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>BBB</span></a>)</p><p>Transplant to gain vascular hierarchy</p><p>Organotypism Through Genetic Drivers</p><p>Dr. Josef Penninger lab Circ Res 2023<br><a href="https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.321768" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">ahajournals.org/doi/10.1161/CI</span><span class="invisible">RCRESAHA.122.321768</span></a></p>
Hao Yin<p>Aortic <a href="https://qoto.org/tags/Endotheliopathy" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Endotheliopathy</span></a> <a href="https://qoto.org/tags/MarfanSyndrome" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MarfanSyndrome</span></a></p><p>En face <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a> morphometry-&gt;<br>Alterations in EC shape/junction/alignment/eNOS Precede aortic dilation in Marfan🐭</p><p>Flow-sensing defect?😆</p><p>Dr. Vivian de Waard lab Scientific Reports 2023 <br><a href="https://www.nature.com/articles/s41598-022-26662-5" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41598-022</span><span class="invisible">-26662-5</span></a></p>
Hao Yin<p>Mechano-vulnerability of <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a> in <a href="https://qoto.org/tags/Atherosclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Atherosclerosis</span></a> 🤠</p><p>EVA1A, elevated by <a href="https://qoto.org/tags/DisturbedFlow" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>DisturbedFlow</span></a>-Twist1 axis, blocks EC <a href="https://qoto.org/tags/Autophagy" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Autophagy</span></a> &amp; induces <a href="https://qoto.org/tags/Apoptosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Apoptosis</span></a> </p><p>Dr. Paul Evans &amp; Jovana Serbanovic-Canic lab ATVB 2023 <br><a href="https://www.ahajournals.org/doi/10.1161/ATVBAHA.122.318110" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">ahajournals.org/doi/10.1161/AT</span><span class="invisible">VBAHA.122.318110</span></a></p><p>Interesting to note that LC3B in EC +72 h <a href="https://qoto.org/tags/DisturbedFlow" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>DisturbedFlow</span></a> is mostly lipidated (Fig. 4A) </p><p>Does this suggest that endothelium under <a href="https://qoto.org/tags/DisturbedFlow" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>DisturbedFlow</span></a> enter an Autophagy-dependent state? For Survival, Shear-sensing &amp; Secretion? 🧐</p>
Hao Yin<p><a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a> <a href="https://qoto.org/tags/Sirt6" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Sirt6</span></a> deficiency-&gt;<br>⏫<a href="https://qoto.org/tags/TissueFactor" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>TissueFactor</span></a>/F3+vascular inflammation genes Cox2, VCAM1, TNFα, MCP1<br>Accelerated Carotid arterial <a href="https://qoto.org/tags/Thrombosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Thrombosis</span></a> (Rose bengal)</p><p>A role in atherosclerotic plaque stability?😃</p><p>Dr. Christian Matter lab JMCC 2022<br><a href="https://www.jmcc-online.com/article/S0022-2828(22)00565-X/fulltext" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">jmcc-online.com/article/S0022-</span><span class="invisible">2828(22)00565-X/fulltext</span></a></p>
Hao Yin<p><a href="https://qoto.org/tags/LaminarShear" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>LaminarShear</span></a> pushes VE-PTP (How?🤓) to downstream pole of <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a>, followed by endocytosis-&gt;⏫p-Tie2</p><p>Potentially explain how <a href="https://qoto.org/tags/DisturbedFlow" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>DisturbedFlow</span></a>⏫<a href="https://qoto.org/tags/VascularPermeability" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>VascularPermeability</span></a> &amp; <a href="https://qoto.org/tags/Atherosclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Atherosclerosis</span></a></p><p>Inhibition of VE-PTP by AKB-9785 fortifies <a href="https://qoto.org/tags/EndothelialBarrier" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialBarrier</span></a> &amp; reduces Atheromas at atheroprone regions (aortic arch inner curvature, arch+intercostal bifurcations)🐭</p><p>Nice comparison of anti-leakage strategies<br>VE-PTP inhibition<br>Angpt1 activation of Tie2<br>Angpt2 inhibition</p><p>Dr. Donald McDonald &amp; Dietmar Vestweber labs EMBO Mol Med 2023<br><a href="https://www.embopress.org/doi/" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="">embopress.org/doi/</span><span class="invisible"></span></a></p>
Hao Yin<p>"Division of Labor" in Lung endothelial host defense 🐭<a href="https://qoto.org/tags/Endotoxemia" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Endotoxemia</span></a> 🐭<a href="https://qoto.org/tags/Influenza" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Influenza</span></a>🐵<a href="https://qoto.org/tags/SARSCOV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SARSCOV2</span></a> </p><p>2 subsets of🫁general capillary <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a><br>Irf7+ immune EC<br>Sox17+ developmental (regenerative) EC </p><p>Dr. Jalees Rehman lab JCI Insight 2022 <br><a href="https://insight.jci.org/articles/view/158079" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">insight.jci.org/articles/view/</span><span class="invisible">158079</span></a></p>
Hao Yin<p>Use Organoid to study Plasticity &amp; Organotypic traits of <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a></p><p>3D Cardiac Microtissue<br><a href="https://qoto.org/tags/hiPSC" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>hiPSC</span></a>-cardiomyocyte, -Fibroblast, -EC</p><p>scRNAseq<br>hiPSC-cardiac mesoderm-EC vs<br>hiPSC-Paraxial mesoderm-EC <br>in🫀Organoid</p><p>Dr. Valeria Orlova lab bioRxiv 2022<br><a href="https://www.biorxiv.org/content/10.1101/2022.11.22.517426v2.full" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">22.11.22.517426v2.full</span></a></p>
Hao Yin<p>Partial <a href="https://qoto.org/tags/EndMT" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndMT</span></a>,⏫by <a href="https://qoto.org/tags/Hypoxia" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Hypoxia</span></a>-induced CD45, as a major cellular source for neointima formation</p><p>50% ECs in ligated artery are CD45+</p><p>CD45 is required to maintain this Partial status<br>Amazing!🤩</p><p>Dr. Yoshito Yamashiro &amp; Yoshito Yamashiro lab <a href="https://qoto.org/tags/CardiovascRes" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CardiovascRes</span></a> 2022 <br><a href="https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvac190/6942105" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">academic.oup.com/cardiovascres</span><span class="invisible">/advance-article/doi/10.1093/cvr/cvac190/6942105</span></a></p><p>How CD45 titrates the extent of mesenchymalization of <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a>?</p><p>CD45 stabilizes VE-cad junction via fortifying integrin α11-SHARPIN complex</p><p>Very interesting data on Biomechanics of <a href="https://qoto.org/tags/EndMT" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndMT</span></a> 😋</p><p>What (beyond CD45) control partial-to-complete EndMT transition?🤓</p>
Hao Yin<p><a href="https://qoto.org/tags/Heme" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Heme</span></a> biosynthesis <a href="https://qoto.org/tags/Angigoenesis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Angigoenesis</span></a></p><p>Roles of <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a> FLVCR1a, a heme exporter to extracellular space in<br>✅Developmental Angiogenesis-🐭Retina🐟ISV <br>✅Tumor angiogenesis<br>❎Vascular homeostasis</p><p>Dr. Sara Petrillo lab Angiogenesis 2023 <br><a href="https://link.springer.com/article/10.1007/s10456-023-09865-w" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">link.springer.com/article/10.1</span><span class="invisible">007/s10456-023-09865-w</span></a></p><p>FLVCR1a deficiency-&gt; <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a>-autonomous defects in Mitochondria, ER stress &amp; Angiogenic behaviors</p><p>Heme accumulation triggers <a href="https://qoto.org/tags/Paraptosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Paraptosis</span></a> (Organelle swelling-&gt; Cytoplasic vacuolation)💀</p><p>Dr. Emanuela Tolosano lab Cell Death Diff 2018 <br><a href="https://www.nature.com/articles/s41418-017-0001-7" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41418-017</span><span class="invisible">-0001-7</span></a></p><p>Other enzymes in Heme metabolism in <a href="https://qoto.org/tags/Angiogensis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Angiogensis</span></a>👇</p><p>Ferrochelatase is a therapeutic target for ocular neovascularization<br><a href="https://www.embopress.org/doi/full/10.15252/emmm.201606561" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">embopress.org/doi/full/10.1525</span><span class="invisible">2/emmm.201606561</span></a></p><p>Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells<br><a href="https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30391-7" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">cell.com/cell-metabolism/fullt</span><span class="invisible">ext/S1550-4131(18)30391-7</span></a></p>
Hao Yin<p>Spatial analysis of Lung microvascular damage+regeneration, correlated with zoned alveolar damage following <a href="https://qoto.org/tags/Influenza" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Influenza</span></a> injury</p><p>A critical role of <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a> COUP-TF2/Nr2f2<br>-Transcriptionally⏫CyclinD1+NRP1<br>-⏬by NFκB</p><p>Dr. Andrew Vaughan lab <span class="h-card"><a href="https://mastodon.world/@vaughandy" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>vaughandy</span></a></span> Science Advances 2020 <br><a href="https://www.science.org/doi/10.1126/sciadv.abc4493" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">science.org/doi/10.1126/sciadv</span><span class="invisible">.abc4493</span></a></p>
Hao Yin<p><a href="https://qoto.org/tags/ThoracicAorticAneurysm" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ThoracicAorticAneurysm</span></a><br><a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a>-<a href="https://qoto.org/tags/SmoothMuscleCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SmoothMuscleCell</span></a> Synergy</p><p>EC Fbln4 KO exacerbates Aortopathy of SMC Fbln4 KO<br>-Aneurysm into Arch<br>-Descending Aortic tortuosity<br>-Postnatal aortic valve thickening/#EndMT</p><p>Dr. Yoshito Yamashiro and Hiromi Yanagisawa labs JAHA2022<br><a href="https://www.ahajournals.org/doi/10.1161/JAHA.122.026942" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">ahajournals.org/doi/10.1161/JA</span><span class="invisible">HA.122.026942</span></a></p>
Hao Yin<p>Tie2+ <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a> Egln1/PHD2 KO mice<br>-&gt;Spontaneous <a href="https://qoto.org/tags/PulmonaryArterialHypertension" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PulmonaryArterialHypertension</span></a> as early as 1.5 mo</p><p>A cascade of EC PHD2 KO-&gt;<br>⏫autocrine <a href="https://qoto.org/tags/CXCL12" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CXCL12</span></a>-&gt;<br>⏫FoxM1-dependent proliferation</p><p>Dr. Zhiyu Dai lab IJMS_MDPI 2021 <br><a href="https://www.mdpi.com/1422-0067/22/6/3182" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="">mdpi.com/1422-0067/22/6/3182</span><span class="invisible"></span></a></p><p>Also read Dr. Dai Circulation 2016🤠presenting EC PHD2 KO, causing PAH via HIF2α (not HIF1α)</p><p>PHD2 Deficiency in Endothelial Cells &amp; Hematopoietic Cells Induces Obliterative Vascular Remodeling &amp; Severe Pulmonary Arterial Hypertension PAH in🐭👤Through HIF2α<br><a href="https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.116.021494" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">ahajournals.org/doi/full/10.11</span><span class="invisible">61/CIRCULATIONAHA.116.021494</span></a></p>
Hao Yin<p>Endotheliopathy <a href="https://qoto.org/tags/CysticFibrosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CysticFibrosis</span></a></p><p>CFTR-deficient <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a><br>⏫Inflammation IL8/SELE/ICAM1/VCAM1<br>⏬Proliferation<br>⏬Autophagy<br>⏬Barrier<br>⏫Mitochodriopathy</p><p>Dr. Lucas Treps, Guy Eelen, Peter Witters labs Eur Respir J 2021<br><a href="https://erj.ersjournals.com/content/57/4/2000261.long" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">erj.ersjournals.com/content/57</span><span class="invisible">/4/2000261.long</span></a></p>
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