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StructBiolCommunicationsThe structure of the tetrameric GINS complex from S. solfataricus reveals a core structure highly similar to the previously determined GINS core structures of other eukaryotes and archaea <a href="https://mstdn.science/tags/DNAReplication" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNAReplication</a> <a href="https://mstdn.science/tags/GINS" class="mention hashtag" rel="nofollow noopener" target="_blank">#GINS</a> <a href="https://mstdn.science/tags/MinichromosomeMaintenance" class="mention hashtag" rel="nofollow noopener" target="_blank">#MinichromosomeMaintenance</a> <a href="https://doi.org/10.1107/S2053230X25003085" rel="nofollow noopener" translate="no" target="_blank">https://doi.org/10.1107/S2053230X25003085</a>

Victoria Stuart 🇨🇦 🏳️‍⚧️Molecular animations reveal DNA's unzipping mechanism: Implications for viral and cancer treatments <a href="https://www.sciencedaily.com/releases/2025/03/250320144758.htm" rel="nofollow noopener" translate="no" target="_blank">https://www.sciencedaily.com/releases/2025/03/250320144758.htm</a> <a href="https://le.ac.uk/news/2025/march/dna-helix-microscopy-cancer" rel="nofollow noopener" translate="no" target="_blank">https://le.ac.uk/news/2025/march/dna-helix-microscopy-cancer</a>* scientists captured 1st detailed 'molecular movie' showing DNA being unzipped at atomic level * reveals how cells begin crucial process of copying their genetic materialStructural dynamics of DNA unwinding by a replicative helicase <a href="https://www.nature.com/articles/s41586-025-08766-w#Sec25" rel="nofollow noopener" translate="no" target="_blank">https://www.nature.com/articles/s41586-025-08766-w#Sec25</a><a href="https://mastodon.social/tags/cancer" class="mention hashtag" rel="nofollow noopener" target="_blank">#cancer</a> <a href="https://mastodon.social/tags/MolecularGenetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#MolecularGenetics</a> <a href="https://mastodon.social/tags/StructuralBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#StructuralBiology</a> <a href="https://mastodon.social/tags/DNAreplication" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNAreplication</a> <a href="https://mastodon.social/tags/DNAhelicase" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNAhelicase</a>

StructBiolCommunicationsThe crystal structure of proliferating cell nuclear antigen 1 from Aeropyrum pernix revealed that it does not form a trimeric ring, unlike those from other domains of life <a href="https://mstdn.science/tags/ProliferatingCellNuclearAntigens" class="mention hashtag" rel="nofollow noopener" target="_blank">#ProliferatingCellNuclearAntigens</a> <a href="https://mstdn.science/tags/DNAReplication" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNAReplication</a> <a href="https://mstdn.science/tags/AeropyrumPernix" class="mention hashtag" rel="nofollow noopener" target="_blank">#AeropyrumPernix</a> <a href="https://doi.org/10.1107/S2053230X24009518" rel="nofollow noopener" translate="no" target="_blank">https://doi.org/10.1107/S2053230X24009518</a>

micrordt Understanding DNA Metabolism: A Complex Dance of Life<a href="https://mastodon.social/tags/DNA" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNA</a>, <a href="https://mastodon.social/tags/DNAMetabolism" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNAMetabolism</a>, <a href="https://mastodon.social/tags/DNARepair" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNARepair</a>, <a href="https://mastodon.social/tags/DNAReplication" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNAReplication</a>, <a href="https://mastodon.social/tags/Metabolis" class="mention hashtag" rel="nofollow noopener" target="_blank">#Metabolis</a>, <a href="https://mastodon.social/tags/Tramsciption" class="mention hashtag" rel="nofollow noopener" target="_blank">#Tramsciption</a> <a href="https://mastodon.social/tags/Genetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#Genetics</a> DNA, the blueprint of life, holds the key to understanding the complexity of living organisms. Its structure, composed of nucleotide…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -<a href="https://micrordt.wordpress.com/2024/05/15/understanding-dna-metabolism-a-complex-dance-of-life/" rel="nofollow noopener" translate="no" target="_blank">https://micrordt.wordpress.com/2024/05/15/understanding-dna-metabolism-a-complex-dance-of-life/</a>

micrordtUnraveling the Mechanisms: Regulation of DNA Replication in Bacterial Cells<a href="https://mastodon.social/tags/Bacteria" class="mention hashtag" rel="nofollow noopener" target="_blank">#Bacteria</a>, <a href="https://mastodon.social/tags/CellCycle" class="mention hashtag" rel="nofollow noopener" target="_blank">#CellCycle</a>, <a href="https://mastodon.social/tags/DNA" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNA</a>, <a href="https://mastodon.social/tags/DNAReplication" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNAReplication</a>, <a href="https://mastodon.social/tags/DnaA" class="mention hashtag" rel="nofollow noopener" target="_blank">#DnaA</a>, <a href="https://mastodon.social/tags/OriC" class="mention hashtag" rel="nofollow noopener" target="_blank">#OriC</a>, <a href="https://mastodon.social/tags/RegulatoryProteins" class="mention hashtag" rel="nofollow noopener" target="_blank">#RegulatoryProteins</a>, <a href="https://mastodon.social/tags/Replication" class="mention hashtag" rel="nofollow noopener" target="_blank">#Replication</a> <a href="https://mastodon.social/tags/Genetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#Genetics</a>, <a href="https://mastodon.social/tags/MolecularBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#MolecularBiology</a> DNA replication is a fundamental process in all living organisms, ensuring the faithful transmission of genetic information from one generation to the next. In bacterial cells, where simplicity meets efficiency…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs…<a href="https://micrordt.wordpress.com/2024/05/01/unraveling-the-mechanisms-regulation-of-dna-replication-in-bacterial-cells/" rel="nofollow noopener" translate="no" target="_blank">https://micrordt.wordpress.com/2024/05/01/unraveling-the-mechanisms-regulation-of-dna-replication-in-bacterial-cells/</a>

micrordtDNA Repair<a href="https://mastodon.social/tags/DNA" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNA</a>, <a href="https://mastodon.social/tags/DNARecombination" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNARecombination</a>, <a href="https://mastodon.social/tags/DNARepair" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNARepair</a>, <a href="https://mastodon.social/tags/DNAReplication" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNAReplication</a>, <a href="https://mastodon.social/tags/DNASequence" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNASequence</a>, <a href="https://mastodon.social/tags/Proofreading" class="mention hashtag" rel="nofollow noopener" target="_blank">#Proofreading</a> <a href="https://mastodon.social/tags/Genetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#Genetics</a> DNA is  most important molecule for working of cell. Although it directly not take part in metabolic pathways, but it keep…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -<a href="https://micrordt.wordpress.com/2024/04/29/dna-repair/" rel="nofollow noopener" translate="no" target="_blank">https://micrordt.wordpress.com/2024/04/29/dna-repair/</a>

micrordtEffects of Mutations <a href="https://mastodon.social/tags/DNA" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNA</a>, <a href="https://mastodon.social/tags/DNAReplication" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNAReplication</a>, <a href="https://mastodon.social/tags/DNASequence" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNASequence</a>, <a href="https://mastodon.social/tags/Mutant" class="mention hashtag" rel="nofollow noopener" target="_blank">#Mutant</a>, <a href="https://mastodon.social/tags/Mutation" class="mention hashtag" rel="nofollow noopener" target="_blank">#Mutation</a> <a href="https://mastodon.social/tags/Genetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#Genetics</a> Mutation is the sudden change in the nucleotide sequence of DNA, they are not predefined i.e. a mutation may be…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -<a href="https://micrordt.wordpress.com/2024/04/29/effects-of-mutations/" rel="nofollow noopener" translate="no" target="_blank">https://micrordt.wordpress.com/2024/04/29/effects-of-mutations/</a>

micrordtMutations And Their Chemical Basis<a href="https://mastodon.social/tags/DNA" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNA</a>, <a href="https://mastodon.social/tags/DNAReplication" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNAReplication</a>, <a href="https://mastodon.social/tags/Mutation" class="mention hashtag" rel="nofollow noopener" target="_blank">#Mutation</a> <a href="https://mastodon.social/tags/Genetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#Genetics</a> Mutations were initially characterized as altered phenotype, but they have now understood at the molecular level. Several types of mutation exist.…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -<a href="https://micrordt.wordpress.com/2024/04/29/mutations-and-their-chemical-basis/" rel="nofollow noopener" translate="no" target="_blank">https://micrordt.wordpress.com/2024/04/29/mutations-and-their-chemical-basis/</a>

Drexel MCBGJasmine Peake and Kalisse Horne, Drexel MCBG PhD students from the lab of Dr. Eishi Noguchi <a href="https://masto.ai/@enog" class="u-url mention" rel="nofollow noopener" target="_blank">@enog</a> published a nice paper about acetaldehyde-induced genomic instability 🤩 Great work, Jasmine and Kalisse 🎉 Please check!!!Jasmine is currently an Assistant Professor at Lincoln University<a href="https://biologists.social/tags/CancerBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#CancerBiology</a> <a href="https://biologists.social/tags/BiomedicalScience" class="mention hashtag" rel="nofollow noopener" target="_blank">#BiomedicalScience</a> <a href="https://biologists.social/tags/GraduateStudies" class="mention hashtag" rel="nofollow noopener" target="_blank">#GraduateStudies</a> <a href="https://biologists.social/tags/DNARepair" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNARepair</a> <a href="https://biologists.social/tags/DNAReplication" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNAReplication</a> <a href="https://www.tandfonline.com/doi/full/10.1080/15384101.2023.2261740" rel="nofollow noopener" translate="no" target="_blank">https://www.tandfonline.com/doi/full/10.1080/15384101.2023.2261740</a>

Phys.orgReferenced link: <a href="https://medicalxpress.com/news/2023-05-dna-replication-discovery-paths-cancer.html" rel="nofollow noopener" target="_blank">https://medicalxpress.com/news/2023-05-dna-replication-discovery-paths-cancer.html</a> Discuss on <a href="https://discu.eu/q/https://medicalxpress.com/news/2023-05-dna-replication-discovery-paths-cancer.html" rel="nofollow noopener" target="_blank">https://discu.eu/q/https://medicalxpress.com/news/2023-05-dna-replication-discovery-paths-cancer.html</a>Originally posted by Phys.org / @physorg_com: <a href="http://nitter.platypush.tech/medical_xpress/status/1653803788359151618#m" rel="nofollow noopener" target="_blank">http://nitter.platypush.tech/medical_xpress/status/1653803788359151618#m</a>RT by @physorg_com: <a href="https://social.platypush.tech/tags/DNAreplication" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNAreplication</a> discovery opens paths to understanding and treating cancer, aging and degenerative disease @VanderbiltU @sciencemagazine <a href="https://www.science.org/doi/10.1126/science.add7328" rel="nofollow noopener" target="_blank">https://www.science.org/doi/10.1126/science.add7328</a> <a href="https://medicalxpress.com/news/2023-05-dna-replication-discovery-paths-cancer.html" rel="nofollow noopener" target="_blank">https://medicalxpress.com/news/2023-05-dna-replication-discovery-paths-cancer.html</a>

Phys.orgReferenced link: <a href="https://phys.org/news/2023-04-motor-dna-replication.html" rel="nofollow noopener" target="_blank">https://phys.org/news/2023-04-motor-dna-replication.html</a> Discuss on <a href="https://discu.eu/q/https://phys.org/news/2023-04-motor-dna-replication.html" rel="nofollow noopener" target="_blank">https://discu.eu/q/https://phys.org/news/2023-04-motor-dna-replication.html</a>Originally posted by Phys.org / @physorg_com: <a href="http://nitter.platypush.tech/physorg_com/status/1649044363819753472#m" rel="nofollow noopener" target="_blank">http://nitter.platypush.tech/physorg_com/status/1649044363819753472#m</a>Researchers shed new light on the motor of <a href="https://social.platypush.tech/tags/DNAreplication" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNAreplication</a> @TUDelft @NatureComms <a href="https://www.nature.com/articles/s41467-023-37093-9" rel="nofollow noopener" target="_blank">https://www.nature.com/articles/s41467-023-37093-9</a> <a href="https://phys.org/news/2023-04-motor-dna-replication.html" rel="nofollow noopener" target="_blank">https://phys.org/news/2023-04-motor-dna-replication.html</a>

Prof AntonyRight on the heels of the @Fusion_Conf on Homologous Recombination in Portugal!! --- RT @mages05 Reg now open! Talk <a href="https://mstdn.social/tags/Cancer" class="mention hashtag" rel="tag">#Cancer</a> <a href="https://mstdn.social/tags/Aging" class="mention hashtag" rel="tag">#Aging</a> <a href="https://mstdn.social/tags/DNAReplication" class="mention hashtag" rel="tag">#DNAReplication</a> <a href="https://mstdn.social/tags/Translation" class="mention hashtag" rel="tag">#Translation</a> <a href="https://mstdn.social/tags/GeneExpression" class="mention hashtag" rel="tag">#GeneExpression</a> at The Helicases and <a href="https://mstdn.social/tags/Nucleic" class="mention hashtag" rel="tag">#Nucleic</a> Acid-based Machines Conf. 7/16-20 <a href="https://mstdn.social/tags/HNASRC" class="mention hashtag" rel="tag">#HNASRC</a>Abstracts Due: 5/14 Info: <a href="http://bit.ly/3JJ5hK1" target="_blank" rel="nofollow noopener" translate="no">http://bit.ly/3JJ5hK1</a> Organizers: @bethtran76 @Trakselis @PaeschkeLab Keynote: @PatrickSungLab <a href="https://twitter.com/taekjip/status/1575285593998622721" target="_blank" rel="nofollow noopener" translate="no">https://twitter.com/taekjip/status/1575285593998622721</a> <a href="https://twitter.com/mages05/status/1621525464400420864" target="_blank" rel="nofollow noopener" translate="no">https://twitter.com/mages05/status/1621525464400420864</a>

Sjors ScheresA fantastic recognition of these amazing scientists' contributions! 🥳 --- RT @MRC_LMB Congratulations to @KellyTHD_Nguyen, @bwfalcon and LMB alumni, @BolandLab_GE and @M_Hospenthal, for being elected @EMBO_YIP! Read the full news story here: <a href="https://www2.mrc-lmb.cam.ac.uk/embo-announces-2023-elections-for-young-investigator-programme/" rel="nofollow noopener" target="_blank">https://www2.mrc-lmb.cam.ac.uk/embo-announces-2023-elections-for-young-investigator-programme/</a><a href="https://fosstodon.org/tags/LMBNews" class="mention hashtag" rel="nofollow noopener" target="_blank">#LMBNews</a> <a href="https://fosstodon.org/tags/LMBAlumni" class="mention hashtag" rel="nofollow noopener" target="_blank">#LMBAlumni</a> <a href="https://fosstodon.org/tags/telomeres" class="mention hashtag" rel="nofollow noopener" target="_blank">#telomeres</a> <a href="https://fosstodon.org/tags/DNAreplication" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNAreplication</a> <a href="https://fosstodon.org/tags/neurodegenerative" class="mention hashtag" rel="nofollow noopener" target="_blank">#neurodegenerative</a> <a href="https://fosstodon.org/tags/diseases" class="mention hashtag" rel="nofollow noopener" target="_blank">#diseases</a> <a href="https://twitter.com/MRC_LMB/status/1595060285261373443" rel="nofollow noopener" target="_blank">https://twitter.com/MRC_LMB/status/1595060285261373443</a>

Peter SarkiesImportant new paper on <a href="https://qoto.org/tags/DNAreplication" class="mention hashtag" rel="nofollow noopener" target="_blank">#DNAreplication</a> from Pierre Murat in Julian Sale's group at the LMB in Cambridge. Interestingly there is a clear signature of mutation surrounding replication origins in mammalian cells such that they mutate more rapidly than non-origin sequences. A consequence of this is presumably that origin of replication move around rapidly over evolutionary timescales (and potentially even in cancer evolution). Interesting from an evolutionary perspective as some eukaryotes (e.g. cerevisiae) have quite localised origins- maintaining these must require quite strong selection- why are localised origins important in some eukaryotes and not others? Link to paper is here: <a href="https://www.science.org/doi/10.1126/sciadv.add3686" rel="nofollow noopener" target="_blank">https://www.science.org/doi/10.1126/sciadv.add3686</a>

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