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#cannabidiol

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RoedigerRG

We will be presenting 3 posters at the #DGKMH in November 2024, #senftenberg
1: "Early detection of #neurodegenerative diseases by multiplex analysis of specific biomarkers using fluorescent microparticles"
2: "Behavioral Differences in Hybridization and Melting Profiles Following Covalent vs. Non-Covalent Oligonucleotide Coupling to #Microbeads via Crosslinkers and Biotin"
3: "#Cannabidiol Does Not Cause DNA Double Strand Breaks in a Human Liver Derived Cell Model"

social.anoxinon.de/@RoedigerRG

The image shows the announcement of the annual meeting of the German Society for Clinical Microcirculation and Hemorheology. The conference will take place on November 15-16, 2024 at the campus of the Brandenburgian Technical University Cottbus-Senftenberg in Senftenberg. In the top part of the image is a text with logo that contains information about date and location. In the lower part of the image you can see a building, the Konrad-Zuse-Media-Center, which serves as an event venue. The building is orange-colored and rounded. There is a green lawn in front of it. To its right are trees visible, above there is a blue sky with few clouds.
Public
formuchdeliberation

Scientists Found a Cannabis Compound Inside a Totally Different Plant : ScienceAlert…

Scientists have discovered cannabidiol, a compound in cannabis known as CBD, in a common Brazilian plant, opening potential new avenues to produce the increasingly popular substance... Science Alert #CBD #cannabis #health #medicalresearch #cannabidiol

formuchdeliberation.wordpress.

for much deliberation · Scientists Found a Cannabis Compound Inside a Totally Different Plant : ScienceAlert…Scientists have discovered cannabidiol, a compound in cannabis known as CBD, in a common Brazilian plant, opening potential new avenues to produce the increasingly popular substance… Science …
Public
DoomsdaysCW

#Cannabidiol (#CBD): a killer for #inflammatory rheumatoid #arthritis synovial fibroblasts

Published: 01 September 2020
by Torsten Lowin, et al.

Abstract:

"Cannabidiol (CBD) is a non-intoxicating phytocannabinoid from cannabis sativa that has demonstrated anti-inflammatory effects in several inflammatory conditions including arthritis. However, CBD binds to several receptors and enzymes and, therefore, its mode of action remains elusive. In this study, we show that CBD increases intracellular calcium levels, reduces cell viability and IL-6/IL-8/MMP-3 production of rheumatoid arthritis synovial fibroblasts (RASF). These effects were pronounced under inflammatory conditions by activating transient receptor potential ankyrin (TRPA1), and by opening of the mitochondrial permeability transition pore. Changes in intracellular calcium and cell viability were determined by using the fluorescent dyes Cal-520/PoPo3 together with cell titer blue and the luminescent dye RealTime-glo. Cell-based impedance measurements were conducted with the XCELLigence system and TRPA1 protein was detected by flow cytometry. Cytokine production was evaluated by ELISA. CBD reduced cell viability, proliferation, and IL-6/IL-8 production of RASF. Moreover, CBD increased intracellular calcium and uptake of the cationic viability dye PoPo3 in RASF, which was enhanced by pre-treatment with TNF. Concomitant incubation of CBD with the TRPA1 antagonist A967079 but not the TRPV1 antagonist capsazepine reduced the effects of CBD on calcium and PoPo3 uptake. In addition, an inhibitor of the mitochondrial permeability transition pore, cyclosporin A, also blocked the effects of CBD on cell viability and IL-8 production. PoPo3 uptake was inhibited by the voltage-dependent anion-selective channel inhibitor DIDS and Decynium-22, an inhibitor for all organic cation transporter isoforms. CBD increases intracellular calcium levels, reduces cell viability, and IL-6/IL-8/MMP-3 production of RASF by activating TRPA1 and mitochondrial targets. This effect was enhanced by pre-treatment with TNF suggesting that CBD preferentially targets activated, pro-inflammatory RASF. Thus, CBD possesses anti-arthritic activity and might ameliorate arthritis via targeting synovial fibroblasts under inflammatory conditions."

Source:
nature.com/articles/s41419-020

NatureCannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts - Cell Death & DiseaseCannabidiol (CBD) is a non-intoxicating phytocannabinoid from cannabis sativa that has demonstrated anti-inflammatory effects in several inflammatory conditions including arthritis. However, CBD binds to several receptors and enzymes and, therefore, its mode of action remains elusive. In this study, we show that CBD increases intracellular calcium levels, reduces cell viability and IL-6/IL-8/MMP-3 production of rheumatoid arthritis synovial fibroblasts (RASF). These effects were pronounced under inflammatory conditions by activating transient receptor potential ankyrin (TRPA1), and by opening of the mitochondrial permeability transition pore. Changes in intracellular calcium and cell viability were determined by using the fluorescent dyes Cal-520/PoPo3 together with cell titer blue and the luminescent dye RealTime-glo. Cell-based impedance measurements were conducted with the XCELLigence system and TRPA1 protein was detected by flow cytometry. Cytokine production was evaluated by ELISA. CBD reduced cell viability, proliferation, and IL-6/IL-8 production of RASF. Moreover, CBD increased intracellular calcium and uptake of the cationic viability dye PoPo3 in RASF, which was enhanced by pre-treatment with TNF. Concomitant incubation of CBD with the TRPA1 antagonist A967079 but not the TRPV1 antagonist capsazepine reduced the effects of CBD on calcium and PoPo3 uptake. In addition, an inhibitor of the mitochondrial permeability transition pore, cyclosporin A, also blocked the effects of CBD on cell viability and IL-8 production. PoPo3 uptake was inhibited by the voltage-dependent anion-selective channel inhibitor DIDS and Decynium-22, an inhibitor for all organic cation transporter isoforms. CBD increases intracellular calcium levels, reduces cell viability, and IL-6/IL-8/MMP-3 production of RASF by activating TRPA1 and mitochondrial targets. This effect was enhanced by pre-treatment with TNF suggesting that CBD preferentially targets activated, pro-inflammatory RASF. Thus, CBD possesses anti-arthritic activity and might ameliorate arthritis via targeting synovial fibroblasts under inflammatory conditions.
#Cannabis#AntiInflammatory
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Manni_P :mastolove:

WTF @taz könnt ihr das global untersuchen lassen? Unsere Gesundheitspolitiker:innen haben offenbar? nicht den Mut und die Haltung! 😠
But the #world should know!

What you need to know

#Cannabidiol (#CBD) is a #cannabis compound with some medicinal properties.

... #studies show that CBD could help #block #infection with #SARS-CoV-2, the #virus that causes #COVID19.

Warum wird/wurde in #Deutschland nicht geforscht?

WTF WTF WTF !!! Sind wir 99% der Menschheit für diese Industrien und Investoren und ihre Politiker:innen sowas wie Meerschweinchen oder weiße Mäuse, oder andere Käfigtiere für ihren perversen Profit - So wie der Cannabis-Nutzer:innen-ZOO der Bundespolizei? 39 Patente - Krebsmedikamte auf Basis GW-Pharm-Hortapharm-Medical-Genomics - Merkel Sauer - Lizensen - Biovia - Moleküldesign ... whole Story CRISPR_rEvolution - Größter Betrug aller Zeiten - Cannabinoide - Endocannabinoidsystem - Immunsystem - Billionengewinne erwartet - Industriekonzerne - Weltmächte ... more coming soon ... Where can I go to learn more? Cannabis and Cannabinoids The National Center for Complementary and Integrative Health has more information about cannabis and CBD. National COVID Cohort Collaborative (N3C) N3C is a partnership among several NIH Institutes and Centers that aims to use COVID-19 clinical data to answer critical research questions. Sources Nguyen, L. C., Yang, D., Nicolaescu, V., Best, T. J., Gula, H., Saxena, D., Gabbard, J. D., Chen, S., Ohtsuki, T., Friesen, J. B., Drayman, N., Mohamed, A., Dann, C., Silva, D., Robinson-Mailman, L., Valdespino, A., Stock, L., Suárez, E., Jones, K. A. … Rosner, M. R. (2022). Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses. Science Advances, 8, eabi6110. https://www.science.org/doi/10.1126/sciadv.abi6110
#Scholz#Lauterbach#Buschmann
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Manni_P :mastolove:

@AuswaertigesAmt könnt ihr das global untersuchen lassen? Unsere Gesundheitspolitker:innen haben offenbar? nicht den Mut und die Haltung! 😠
But the world should know!

What you need to know

#Cannabidiol (#CBD) is a #cannabis compound with some medicinal properties.

... #studies show that CBD could help #block #infection with #SARS-CoV-2, the #virus that causes #COVID19.

Warum wird/wurde in Deutschland nicht geforscht Herr #Scholz #Lauterbach #Buschmann #Lindner #Habeck #Merz #Linnemann #fff

Where can I go to learn more? Cannabis and Cannabinoids Cannabis Mediklamente weltweiter gigantischer Betrug Historie GW-Pharm Hortapharm Medical Genomics more coming soon ... NCI provides patient-friendly information about cannabis and its compounds. Cannabis (Marijuana) and Cannabinoids: What You Need to Know The National Center for Complementary and Integrative Health has more information about cannabis and CBD. National COVID Cohort Collaborative (N3C) N3C is a partnership among several NIH Institutes and Centers that aims to use COVID-19 clinical data to answer critical research questions. Sources Nguyen, L. C., Yang, D., Nicolaescu, V., Best, T. J., Gula, H., Saxena, D., Gabbard, J. D., Chen, S., Ohtsuki, T., Friesen, J. B., Drayman, N., Mohamed, A., Dann, C., Silva, D., Robinson-Mailman, L., Valdespino, A., Stock, L., Suárez, E., Jones, K. A. … Rosner, M. R. (2022). Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses. Science Advances, 8, eabi6110. https://www.science.org/doi/10.1126/sciadv.abi6110
Continued thread
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Marine Mas, PhD

(diapos du Dr QUEUILLE) En ccl: faites attention aux interactions avec les médicaments (psychotropes tels que Seroplex, Atharax; Methadone, mais aussi non-psychotropes car risque hémorragique avec certains anti-coagulants par exemple). Les produits ne sont pas toujours conformes à l'étiquetage donc compliqué d'évaluer le risque systématiquement. Prêter attention au mode de consommation qui influe largement sur la pharmacocinétique.
#CBD #Psychotropes #addicto #cannabidiol

Molécule pléiotrope, nouvelle alternative thérapeutique, bon profil de sécurité et de tolérance à faible dose MAIS nécéssité d'amliorer le contrôle des produits, difficulté d'établir une relation dose-effet, nécéssité de préciser les risques d'interaction Que dire a son patient sous CBD ? difficile d'émettre une conduit eà tenir générale, les décisions doivent être prises au cas par cas
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Matt Willemsen

The Healing Power of Cannabis – Scientists Shed New Light on Its Anti-Inflammatory Effects
Researchers from the Institute of Pharmacy in Jena studied the anti-inflammatory effects of cannabinoids, particularly focusing on CBD (cannabidiol). They found that CBD activates an enzyme leading to inflammation resolution and believe these findings could result in new treatments for inflammatory diseases.
scitechdaily.com/the-healing-p #cannabis #pharmaceutical #AntiInflammatory #CBD #cannabidiol #enzyme #15lipoxygenase1

SciTechDailyThe Healing Power of Cannabis – Scientists Shed New Light on Its Anti-Inflammatory EffectsAn international research team has clarified the mode of action of cannabinoids in inflammation. The German federal government recently made the contentious choice to decriminalize the ownership and purchase of minor quantities of cannabis. Should the German legislature approve the draft bill, t
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