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jobRxivPhD in Immunotherapy & 3D Tumor Models – IMol, Polish Academy of Sciences The International Institute of Molecular Mechanisms See the full job description on jobRxiv: <a href="https://jobrxiv.org/job/the-international-institute-of-molecular-mechanisms-27778-phd-in-cancer-immunotherapy-3d-tumor-models/" rel="nofollow noopener" translate="no" target="_blank">https://jobrxiv.org/job/the-international-institute-of-molecular-mechanisms-27778-phd-in-cancer-immunotherapy-3d-tumor-models/</a><a href="https://mas.to/tags/3dtumormodels" class="mention hashtag" rel="nofollow noopener" target="_blank">#3dtumormodels</a> <a href="https://mas.to/tags/cancerimmunology" class="mention hashtag" rel="nofollow noopener" target="_blank">#cancerimmunology</a> <a href="https://mas.to/tags/tumormicroenvironment" class="mention hashtag" rel="nofollow noopener" target="_blank">#tumormicroenvironment</a> <a href="https://mas.to/tags/Scie" class="mention hashtag" rel="nofollow noopener" target="_blank">#Scie</a>... <a href="https://jobrxiv.org/job/the-international-institute-of-molecular-mechanisms-27778-phd-in-cancer-immunotherapy-3d-tumor-models/?fsp_sid=228" rel="nofollow noopener" translate="no" target="_blank">https://jobrxiv.org/job/the-international-institute-of-molecular-mechanisms-27778-phd-in-cancer-immunotherapy-3d-tumor-models/?fsp_sid=228</a>

David GraylessCancer <a href="https://mastodon.social/tags/immunotherapy" class="mention hashtag" rel="nofollow noopener" target="_blank">#immunotherapy</a> (immuno-oncotherapy) is the stimulation of the <a href="https://mastodon.social/tags/immuneSystem" class="mention hashtag" rel="nofollow noopener" target="_blank">#immuneSystem</a> to treat cancer, improving the immune system's natural ability to fight the disease. It is an application of the <a href="https://mastodon.social/tags/fundamentalResearch" class="mention hashtag" rel="nofollow noopener" target="_blank">#fundamentalResearch</a> of <a href="https://mastodon.social/tags/cancerImmunology" class="mention hashtag" rel="nofollow noopener" target="_blank">#cancerImmunology</a> (immuno-<a href="https://mastodon.social/tags/oncology" class="mention hashtag" rel="nofollow noopener" target="_blank">#oncology</a>) and a growing subspecialty of oncology. Cancer immunotherapy exploits the fact that <a href="https://mastodon.social/tags/cancerCells" class="mention hashtag" rel="nofollow noopener" target="_blank">#cancerCells</a> often have <a href="https://mastodon.social/tags/tumorAntigens" class="mention hashtag" rel="nofollow noopener" target="_blank">#tumorAntigens</a>, molecules on their surface that can bind to <a href="https://mastodon.social/tags/antibody" class="mention hashtag" rel="nofollow noopener" target="_blank">#antibody</a> <a href="https://mastodon.social/tags/proteins" class="mention hashtag" rel="nofollow noopener" target="_blank">#proteins</a> or <a href="https://mastodon.social/tags/TcellReceptors" class="mention hashtag" rel="nofollow noopener" target="_blank">#TcellReceptors</a>.

jobRxivPostdoctoral Fellow The de Cubas Lab in the Department of Microbiology & Immunology at the Medical University of South Carolina and the Hollings Cancer Center has an open<a href="https://jobrxiv.org/job/medical-university-of-south-carolina-27778-postdoctoral-fellow/?feed_id=43710" rel="nofollow noopener" target="_blank">https://jobrxiv.org/job/medical-university-of-south-carolina-27778-postdoctoral-fellow/?feed_id=43710</a><a href="https://mas.to/tags/ScienceJobs" class="mention hashtag" rel="nofollow noopener" target="_blank">#ScienceJobs</a> <a href="https://mas.to/tags/job" class="mention hashtag" rel="nofollow noopener" target="_blank">#job</a> <a href="https://mas.to/tags/CancerImmunology" class="mention hashtag" rel="nofollow noopener" target="_blank">#CancerImmunology</a> Charleston <a href="https://mas.to/tags/U" class="mention hashtag" rel="nofollow noopener" target="_blank">#U</a>... <a href="https://jobrxiv.org/job/medical-university-of-south-carolina-27778-postdoctoral-fellow/?feed_id=43710" rel="nofollow noopener" target="_blank">https://jobrxiv.org/job/medical-university-of-south-carolina-27778-postdoctoral-fellow/?feed_id=43710</a>

jobRxivPostdoctoral Fellow The de Cubas Lab in the Department of Microbiology & Immunology at the Medical University of South Carolina and the Hollings Cancer Center has an open<a href="https://jobrxiv.org/job/medical-university-of-south-carolina-27778-postdoctoral-fellow/?feed_id=42282" rel="nofollow noopener" target="_blank">https://jobrxiv.org/job/medical-university-of-south-carolina-27778-postdoctoral-fellow/?feed_id=42282</a><a href="https://mas.to/tags/ScienceJobs" class="mention hashtag" rel="nofollow noopener" target="_blank">#ScienceJobs</a> <a href="https://mas.to/tags/job" class="mention hashtag" rel="nofollow noopener" target="_blank">#job</a> <a href="https://mas.to/tags/CancerImmunology" class="mention hashtag" rel="nofollow noopener" target="_blank">#CancerImmunology</a> Charleston <a href="https://mas.to/tags/U" class="mention hashtag" rel="nofollow noopener" target="_blank">#U</a>... <a href="https://jobrxiv.org/job/medical-university-of-south-carolina-27778-postdoctoral-fellow/?feed_id=42282" rel="nofollow noopener" target="_blank">https://jobrxiv.org/job/medical-university-of-south-carolina-27778-postdoctoral-fellow/?feed_id=42282</a>

Arjan BoltjesRecent work from University of Basel in Nature Communications looking into <a href="https://mastodon.social/tags/Tcell" class="mention hashtag" rel="nofollow noopener" target="_blank">#Tcell</a> <a href="https://mastodon.social/tags/exhaustion" class="mention hashtag" rel="nofollow noopener" target="_blank">#exhaustion</a>, indicating a role for the SNX9 <a href="https://mastodon.social/tags/gene" class="mention hashtag" rel="nofollow noopener" target="_blank">#gene</a>. Knocking out this gene led to phenotypical and functional changes, e.g. Tmem differentiation, IFNg production, reduced <a href="https://mastodon.social/tags/tumour" class="mention hashtag" rel="nofollow noopener" target="_blank">#tumour</a> growth, and improved survival in certain models.<a href="https://www.nature.com/articles/s41467-022-35583-w" rel="nofollow noopener" target="_blank">https://www.nature.com/articles/s41467-022-35583-w</a><a href="https://mastodon.social/tags/Tcells" class="mention hashtag" rel="nofollow noopener" target="_blank">#Tcells</a> <a href="https://mastodon.social/tags/Cancer" class="mention hashtag" rel="nofollow noopener" target="_blank">#Cancer</a> <a href="https://mastodon.social/tags/Immunology" class="mention hashtag" rel="nofollow noopener" target="_blank">#Immunology</a> <a href="https://mastodon.social/tags/lymphocytes" class="mention hashtag" rel="nofollow noopener" target="_blank">#lymphocytes</a> <a href="https://mastodon.social/tags/CancerImmunology" class="mention hashtag" rel="nofollow noopener" target="_blank">#CancerImmunology</a> <a href="https://mastodon.social/tags/SingleCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#SingleCell</a> <a href="https://mastodon.social/tags/scRNAseq" class="mention hashtag" rel="nofollow noopener" target="_blank">#scRNAseq</a> <a href="https://mastodon.social/tags/RNAseq" class="mention hashtag" rel="nofollow noopener" target="_blank">#RNAseq</a>Found via <a href="https://mastodon.social/@sflorg" class="u-url mention" rel="nofollow noopener" target="_blank">@sflorg</a>

John F. FoleyNK cells recognize and kill tumor cells; thus, they are used in immunotherapies. The contact site between an NK cell and its target is called an immunological synapse (IS). In Nature Immunology, Oh et al. found that an NK cell receptor called NgR1 (best known for its function in neurons) destabilized the IS, leading to reduced target cell killing. Thus, targeting this receptor may enhance NK cell-based immunotherapies. Read my summary here: <a href="https://www.science.org/doi/10.1126/scisignal.adg6157" rel="nofollow noopener" target="_blank">https://www.science.org/doi/10.1126/scisignal.adg6157</a> <a href="https://mastodon.social/tags/science" class="mention hashtag" rel="nofollow noopener" target="_blank">#science</a> <a href="https://mastodon.social/tags/CancerImmunology" class="mention hashtag" rel="nofollow noopener" target="_blank">#CancerImmunology</a>

Seth Thomas ScanlonIn <a href="https://mstdn.social/tags/Science" class="mention hashtag" rel="tag">#Science</a> (<a href="https://sciencemastodon.com/@sciencemagazine" class="u-url mention">@sciencemagazine</a>) this week, the Hanahan lab shows that the <a href="https://mstdn.social/tags/RNA" class="mention hashtag" rel="tag">#RNA</a>-binding protein <a href="https://mstdn.social/tags/FMRP" class="mention hashtag" rel="tag">#FMRP</a> enables <a href="https://mstdn.social/tags/tumors" class="mention hashtag" rel="tag">#tumors</a> to evade being attacked by <a href="https://mstdn.social/tags/CD8TCells" class="mention hashtag" rel="tag">#CD8TCells</a>. It does so by both suppressing <a href="https://mstdn.social/tags/CCL17" class="mention hashtag" rel="tag">#CCL17</a> & promoting <a href="https://mstdn.social/tags/Tregs" class="mention hashtag" rel="tag">#Tregs</a> via <a href="https://mstdn.social/tags/IL33" class="mention hashtag" rel="tag">#IL33</a> & <a href="https://mstdn.social/tags/M2" class="mention hashtag" rel="tag">#M2</a> <a href="https://mstdn.social/tags/macrophages" class="mention hashtag" rel="tag">#macrophages</a> via <a href="https://mstdn.social/tags/PROS1" class="mention hashtag" rel="tag">#PROS1</a> & <a href="https://mstdn.social/tags/ExtracellularVesicles" class="mention hashtag" rel="tag">#ExtracellularVesicles</a>!<a href="https://bit.ly/Sci_abl7207" target="_blank" rel="nofollow noopener" translate="no">https://bit.ly/Sci_abl7207</a><a href="https://mstdn.social/tags/CancerImmunology" class="mention hashtag" rel="tag">#CancerImmunology</a> <a href="https://mstdn.social/tags/RBP" class="mention hashtag" rel="tag">#RBP</a>

Arun WadhwaHey all! I guess I owe you all lovelies an introduction, so here you go:I’m a Physician/Doctor, Student Researcher, and ex-Web-Developer, currently residing in New Delhi, India. My fields of interest include - <a href="https://mastodon.social/tags/CancerImmunology" class="mention hashtag" rel="nofollow noopener" target="_blank">#CancerImmunology</a>, <a href="https://mastodon.social/tags/VaccineDevelopment" class="mention hashtag" rel="nofollow noopener" target="_blank">#VaccineDevelopment</a>, and <a href="https://mastodon.social/tags/NeurodegenerativeDisorders" class="mention hashtag" rel="nofollow noopener" target="_blank">#NeurodegenerativeDisorders</a>.I love listening to Classical & Indie Music, Discovering eateries & other hidden gems, Tech-Talk, and everything Medicine. Feel free to shoot me a reply or a private message! <a href="https://mastodon.social/tags/MedMastodon" class="mention hashtag" rel="nofollow noopener" target="_blank">#MedMastodon</a>

Seth Thomas ScanlonNow in <a href="https://mstdn.social/tags/Science" class="mention hashtag" rel="tag">#Science</a> magazine (<a href="https://sciencemastodon.com/@sciencemagazine" class="u-url mention">@sciencemagazine</a>)Katherine Freitas, Julia Belk, Ansu Satpathy, Crystal Mackall, & colleagues use <a href="https://mstdn.social/tags/CRISPR" class="mention hashtag" rel="tag">#CRISPR</a> screen to identify MED12 & CCNC as key regulators of human <a href="https://mstdn.social/tags/TCell" class="mention hashtag" rel="tag">#TCell</a> activation & function. Inactivation in <a href="https://mstdn.social/tags/CART" class="mention hashtag" rel="tag">#CART</a> cells leads to increased T cell expansion, <a href="https://mstdn.social/tags/metabolic" class="mention hashtag" rel="tag">#metabolic</a> fitness, & <a href="https://mstdn.social/tags/tumor" class="mention hashtag" rel="tag">#tumor</a> control!bit.ly/Sci_abn5647Be sure to also check out the accompanying Perspective by Caitlin Zebley & Ben Youngblood:<a href="https://bit.ly/Sci_adf0546" target="_blank" rel="nofollow noopener" translate="no">https://bit.ly/Sci_adf0546</a><a href="https://mstdn.social/tags/CancerImmunology" class="mention hashtag" rel="tag">#CancerImmunology</a> <a href="https://mstdn.social/tags/immunotherapy" class="mention hashtag" rel="tag">#immunotherapy</a>

Claire McCarthyNovember 17th at 12:00 pm ET, there will be a a joint <a href="https://mstdn.social/tags/CancerMoonshot" class="mention hashtag" rel="tag">#CancerMoonshot</a>, NCI Emerging Technologies, and <a href="https://mstdn.social/tags/DataViz4Cancer" class="mention hashtag" rel="tag">#DataViz4Cancer</a> Seminar. Dr. Zeynep Gumus will share the development of a user-friendly tool to enable <a href="https://mstdn.social/tags/dataviz" class="mention hashtag" rel="tag">#dataviz</a> for <a href="https://mstdn.social/tags/cancerimmunology" class="mention hashtag" rel="tag">#cancerimmunology</a>. Registration: <a href="https://events.cancer.gov/cm/seminarseries/registration" target="_blank" rel="nofollow noopener" translate="no">https://events.cancer.gov/cm/seminarseries/registration</a><a href="https://mstdn.social/tags/CancerMoonshotSeminarSeries" class="mention hashtag" rel="tag">#CancerMoonshotSeminarSeries</a> <a href="https://mstdn.social/tags/CMSSGumus" class="mention hashtag" rel="tag">#CMSSGumus</a> <a href="https://mstdn.social/tags/datavisualization" class="mention hashtag" rel="tag">#datavisualization</a> <a href="https://mstdn.social/tags/CancerResearch" class="mention hashtag" rel="tag">#CancerResearch</a>

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