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PShockettA cool experiment on CD8 T cell proliferative expansion and memory. Upon adoptive transfer (to a different mouse) "functionally competent T cells can retain the potential for extraordinary population expansion and longevity well beyond their organismal lifespan." (at least 10 years!)<a href="https://mastodon.world/tags/Tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tcells</a> <a href="https://mastodon.world/tags/CD8Tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CD8Tcells</a> <a href="https://mastodon.world/tags/Tcellmemory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tcellmemory</a> <a href="https://mastodon.world/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunology</a> <a href="https://mastodon.world/tags/immuneresponse" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immuneresponse</a> <a href="https://mastodon.world/tags/celllongevity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#celllongevity</a> <a href="https://mastodon.world/tags/cellproliferation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cellproliferation</a> "Functional T cells are capable of supernumerary cell division and longevity"<a href="https://www.nature.com/articles/s41586-022-05626-9?s=09" rel="nofollow noopener noreferrer" target="_blank">https://www.nature.com/articles/s41586-022-05626-9?s=09</a>

Thiago Carvalho'Long-lasting sepsis-induced immunoparalysis has been principally studied in primary (1°) memory CD8 T cells; however, the impact of sepsis on memory CD8 T cells with a history of repeated cognate Ag encounters is largely unknown but important in understanding the role of sepsis in shaping the pre-existing memory CD8 T cell compartment.'<a href="https://qoto.org/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunology</a> <a href="https://qoto.org/tags/Sepsis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Sepsis</a> <a href="https://qoto.org/tags/CTL" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CTL</a> <a href="https://qoto.org/tags/cd8tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cd8tcells</a> <a href="https://journals.aai.org/jimmunol/article-abstract/210/2/168/237582/Inefficient-Recovery-of-Repeatedly-Stimulated?redirectedFrom=fulltext" rel="nofollow noopener noreferrer" target="_blank">https://journals.aai.org/jimmunol/article-abstract/210/2/168/237582/Inefficient-Recovery-of-Repeatedly-Stimulated?redirectedFrom=fulltext</a>

Dreamtraveler (Mary Ann)<a href="https://www.medrxiv.org/content/10.1101/2022.11.25.22282759v1" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://www.medrxiv.org/content/10.1101/2022.11.25.22282759v1</a> — Patients with severe <a href="https://mstdn.social/tags/disease" class="mention hashtag" rel="tag">#disease</a> displayed persistent activation of <a href="https://mstdn.social/tags/CD4plus" class="mention hashtag" rel="tag">#CD4plus</a> and <a href="https://mstdn.social/tags/CD8TCells" class="mention hashtag" rel="tag">#CD8TCells</a> <a href="https://mstdn.social/tags/T_cells" class="mention hashtag" rel="tag">#T_cells</a> — Elevated <a href="https://mstdn.social/tags/plasma" class="mention hashtag" rel="tag">#plasma</a> levels of IL-4, IL-7, IL-17 and TNF-α were present in <a href="https://mstdn.social/tags/patients" class="mention hashtag" rel="tag">#patients</a> with severe — disease. — persistent T-cell activation — <a href="https://mstdn.social/tags/SevereCOVID" class="mention hashtag" rel="tag">#SevereCOVID</a>-19 —Patients with severe disease reported a higher number of <a href="https://mstdn.social/tags/LongCOVID" class="mention hashtag" rel="tag">#LongCOVID</a> symptoms which correlated with the frequency of two subsets of activated CD4+ and CD8+ T cells — <a href="https://mstdn.social/tags/MaskUp" class="mention hashtag" rel="tag">#MaskUp</a>

Seth Thomas ScanlonIn <a href="https://mstdn.social/tags/Science" class="mention hashtag" rel="tag">#Science</a> (<a href="https://sciencemastodon.com/@sciencemagazine" class="u-url mention">@sciencemagazine</a>) this week, the Hanahan lab shows that the <a href="https://mstdn.social/tags/RNA" class="mention hashtag" rel="tag">#RNA</a>-binding protein <a href="https://mstdn.social/tags/FMRP" class="mention hashtag" rel="tag">#FMRP</a> enables <a href="https://mstdn.social/tags/tumors" class="mention hashtag" rel="tag">#tumors</a> to evade being attacked by <a href="https://mstdn.social/tags/CD8TCells" class="mention hashtag" rel="tag">#CD8TCells</a>. It does so by both suppressing <a href="https://mstdn.social/tags/CCL17" class="mention hashtag" rel="tag">#CCL17</a> & promoting <a href="https://mstdn.social/tags/Tregs" class="mention hashtag" rel="tag">#Tregs</a> via <a href="https://mstdn.social/tags/IL33" class="mention hashtag" rel="tag">#IL33</a> & <a href="https://mstdn.social/tags/M2" class="mention hashtag" rel="tag">#M2</a> <a href="https://mstdn.social/tags/macrophages" class="mention hashtag" rel="tag">#macrophages</a> via <a href="https://mstdn.social/tags/PROS1" class="mention hashtag" rel="tag">#PROS1</a> & <a href="https://mstdn.social/tags/ExtracellularVesicles" class="mention hashtag" rel="tag">#ExtracellularVesicles</a>!<a href="https://bit.ly/Sci_abl7207" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://bit.ly/Sci_abl7207</a><a href="https://mstdn.social/tags/CancerImmunology" class="mention hashtag" rel="tag">#CancerImmunology</a> <a href="https://mstdn.social/tags/RBP" class="mention hashtag" rel="tag">#RBP</a>

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