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#biophysics

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BG · berlinergazette.de

Humanity is at a critical juncture. We are being torn apart by wars, pandemics, geopolitical rivalries, and ecological upheaval. The time has come to make important choices. Based on his research, which combines political with a critique of Erald Kolasi addresses the fundamental challenges we face and offers a new blueprint for understanding and solving them: berlinergazette.de/overcoming-

BG · berlinergazette.de · EN|DE · Beyond Peak Anything: How to Overcome Capitalism and Its Catastrophic Shock to the Biosphere · BG · berlinergazette.de · EN|DEHumanity is at a critical juncture. We are being torn apart by wars, pandemics, geopolitical rivalries, and ecological upheaval. The time has come to make important choices that could have a profound impact on the future of human civilization. Based on his research, which combines political biophysics with a critique of capitalism, Erald Kolasi addresses the fundamental challenges we face and offers a new blueprint for understanding and solving them.
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Enabla

Dr. Ali Hassanali from the Abdus Salam International Centre for Theoretical Physics (ICTP) is back with a new lecture! This time, Ali discusses the role of amide bonds and dipole moments in the dynamics and stability of protein folding. He investigates how amino acid sequences transform from unfolded to folded states, emphasizing the various interactions that play a crucial role in this fundamental biological process.

🎥 You can access this hashtag#OpenAccess lecture for free on Enabla and engage in meaningful online discussions with Dr. Hassanali and the Enabla community regarding protein folding dynamics and stability: enabla.com/pub/1024/about

This is a fantastic opportunity to expand your understanding of protein structure and the factors influencing it, including external conditions like pH and temperature, as well as the impact of post-translational modifications.

The ICTP diploma program lecture "Understanding Protein Folding: Interactions, Dynamics, and Thermodynamics" by Dr. Ali Hassanali is on Enabla in Open Access! Video, English, 1.1 hours
#Biophysics#ProteinFolding#MolecularBiology
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mechanochemistry

🚨NEW PREPRINT 🚨 from the Cross lab.

Karnawat et al.

ATPγS unbiases kinesin

doi.org/10.1101/2025.05.01.651

bioRxiv · ATPγS unbiases kinesinKinesin-1 microtubule motors are ATP-fuelled, twin-headed cargo transporters that step processively along microtubules, with a load-dependent directional bias. Here we show using single molecule optical trapping that 1 mM ATPγS, a slowly-hydrolysed analogue, substantially defeats the biasing mechanism, whereas 1 μM ATPγS supports it. Our data argue that kinesin re-registers itself between steps into an Await-Isomerisation (AI) state that engenders both on-axis steps and off-axis missteps, and that missteps can be rescued. In the AI state, ATP or ATPγS is bound but neck-linker docking and nucleotide hydrolysis are inhibited. Load-dependent exit from the AI state establishes hydrolytic competence via catalytic site closure and coupled neck-linker docking, which guides the tethered head to its next on-axis site. By overpopulating the AI state, ATPγS reveals its pivotal role in the biasing mechanism, whose control logic maximises steered diffusion-to-capture of the leading kinesin-1 head under load, at the expense of futile nucleotide turnover. ### Competing Interest Statement The authors have declared no competing interest. Wellcome TrustWellcome Trust, , 220387/Z/20/Z
#motorheads#cytoskeleton#cellBiology
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Neurofrontiers

A few weeks ago, I shared a differential equations tutorial for beginners, written from the perspective of a neuroscientist who's had to grapple with the computational part. Following up on that, I've now tackled the first real beast encountered by most computational neuroscience students: the Hodgkin-Huxley model.

While remaining incredibly elegant to this day, this model is also a mathematically dense system of equations that can overwhelm and discourage beginners, especially those with non-mathematical backgrounds. Similar to the first tutorial, I've tried to build intuition step-by-step, starting with a simple RC circuit, layering in Na⁺ and K⁺ channels, and ending with the full spike-generation story.

Feedback is welcome, especially from fellow non-math converts.
neurofrontiers.blog/building-a

#ComputationalNeuroscience #Python #hodgkinHuxleyModel #math #biophysics

From: @neurofrontiers
neuromatch.social/@neurofronti

Neurofrontiers · Building a virtual neuron - part 2 - Neurofrontiers
More from neuronerd
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ScienceOpen

'BIO Integration' is a platinum #OpenAccess journal focusing on original, cutting-edge, interdisciplinary contents in the field of biosciences - including #Medicine, #Biochemistry, #Biophysics, #Bioengineering, #Biotechnology, etc. - which generate hypotheses and questions relevant to the patient and disease and guide the investigations of cellular and molecular medicine: scienceopen.com/collection/BIO

ScienceOpenBIO Integration<p><em>BIO Integration</em> is a<strong> platinum open access</strong> journal focusing on original, cutting-edge, interdisciplinary contents in the field of biosciences, including medicine, biochemistry, biophysics, bioengineering, biotechnology, etc., which generate hypotheses and questions relevant to the patient and disease and guide the investigations of cellular and molecular medicine. </p><p><strong>eISSN</strong> 2712-0082 <strong>ISSN </strong>2712-0074</p><p> </p>
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Europe Says

europesays.com/1997473/ Bifurcation analysis, modulation instability and dynamical analysis of soliton solutions for generalized (3 + 1)-dimensional nonlinear wave equation with m-fractional operator #BifurcationTheory #Biophysics #Data #GalileanTransformation #Generalized(3 + 1)DimensionalTypeNonlinearWaveEquation #HamiltonianFunction #HumanitiesAndSocialSciences #MathematicsAndComputing #ModifiedSimpleEquationTechnique #multidisciplinary #NonlinearSystems #physics #science

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