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#academictwitter

1 post1 participant0 posts today
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Roel van der Ploeg

Thrilled to share my 1st paper in @nature.portfolio npj Biofilms & Microbiomes! We show how Parallel Factor Analysis reveals microbial subcommunities & pathways in gingivitis. Thanks to my coauthors!

buff.ly/421t1C5

NatureMulti-way modelling of oral microbial dynamics and host-microbiome interactions during induced gingivitis - npj Biofilms and MicrobiomesGingivitis—the inflammation of the gums—is a reversible stage of periodontal disease. It is caused by dental plaque formation due to poor oral hygiene. However, gingivitis susceptibility involves a complex set of interactions between the oral microbiome, oral metabolome and the host. In this study, we investigated the dynamics of the oral microbiome and its interactions with the salivary metabolome during experimental gingivitis in a cohort of 41 systemically healthy participants. We use Parallel Factor Analysis (PARAFAC), which is a multi-way generalization of Principal Component Analysis (PCA) that can model the variability in the response due to subjects, variables and time. Using the modelled responses, we identified microbial subcommunities with similar dynamics that connect to the magnitude of the gingivitis response. By performing high level integration of the predicted metabolic functions of the microbiome and salivary metabolome, we identified pathways of interest that describe the changing proportions of Gram-positive and Gram-negative microbiota, variation in anaerobic bacteria, biofilm formation and virulence.
#Microbiome#AcademicTwitter#phdlife
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Ankur Sinha "FranciscoD"

The BRAIN initiative: a pioneering program on the precipice | Nature Neuroscience: nature.com/articles/s41593-024

NatureThe BRAIN initiative: a pioneering program on the precipice - Nature NeuroscienceLaunched in 2013, the BRAIN Initiative (BRAIN) in the United States aimed to unlock the mysteries of the brain and develop new treatments for neurological and neuropsychiatric disorders. The success of this program is evidenced by the accelerated discoveries and development of interventions that are happening in real time. However, a recent 40% cut in funding for BRAIN threatens this once-in-a-generation opportunity to solve fundamental mysteries of the brain and achieve treatment breakthroughs that we once thought impossible.
#Neuroscience#AcademicTwitter
Continued thread
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Victoria ¯⁠\⁠_⁠(⁠ツ⁠)⁠_⁠/⁠¯

As an addition, sometimes I feel academic writing is a weird combination of "content" – in the best or worst Netflix sense, meaning that we produce a lot of "the same" kind of material – and poetry – in the sense of self-expression. It's a good thing, too, to have the chance to publish how you think about the world without caring whether anyone should bother. It's a bad thing, too, cause it's incredibly self-centred and not at all communitarian or "social" to the least. #academictwitter

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