You know that thing where people make fun of a terrible opinion by writing it in a mixture of upper and lower case? It's probably not a good idea.
Screenreader software used by blind or partially-sighted people interprets capital letters as the beginning of a word.
This means that a phrase written as "FiNe PEopLe oN BoTh siDeS" will sound like gibberish.
If accessibility matters to you, try to avoid doing this.