One or two accounts regularly posting things that don't interest you is manageable, but the more you add, the easier it is to lose the signal in the noise. With no algorithm working to keep you addicted, it's easy to let your Home timeline get overrun. Follow freely, but also be ready to unfollow for basic quality of life reasons. The Federated timeline can be overwhelming, but your Home timeline shouldn't be. You have to tend it like a garden, and a little pruning goes a long way. #feditips
Mastodon provides several tools for managing your timeline.
You can add notes to any profile. Why did you follow them? Are they a repeat offender? Remind yourself.
You can disable boosts on a per-user basis. Maybe you want to see a user's posts, but not everything that interests them.
You can temporarily mute an account while they get something out of their system.
You filter out posts with specific words, hashtags or phrases.
And when all else fails: block, unfollow, or mute indefinitely.